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best-19 Bestrophin homolog [ Caenorhabditis elegans ]

Gene ID: 13191891, updated on 4-Jan-2025

Summary

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Official Symbol
best-19
Official Full Name
Bestrophin homolog
Primary source
WormBase:WBGene00206487
Locus tag
CELE_T21D12.15
See related
AllianceGenome:WB:WBGene00206487
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy; bestrophinopathy; macular degeneration; retinitis pigmentosa 50; and vitelliform macular dystrophy. Orthologous to several human genes including BEST1 (bestrophin 1); BEST2 (bestrophin 2); and BEST3 (bestrophin 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See best-19 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (283647..287215)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Leucine-rich repeats and immunoglobulin-like domains protein sma-10 Neighboring gene Secreted protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bestrophin homolog
NP_001255219.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    283647..287215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268290.3 → NP_001255219.1  Bestrophin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255219.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16779, O16781
    Conserved Domains (1) summary
    pfam01062
    Location:8 → 321
    Bestrophin; Bestrophin, RFP-TM, chloride channel
Nucleotide Protein
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