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C4orf33 chromosome 4 open reading frame 33 [ Homo sapiens (human) ]

Gene ID: 132321, updated on 27-Nov-2024

Summary

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Official Symbol
C4orf33provided by HGNC
Official Full Name
chromosome 4 open reading frame 33provided by HGNC
Primary source
HGNC:HGNC:27025
See related
Ensembl:ENSG00000151470 AllianceGenome:HGNC:27025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in colon (RPKM 3.9), duodenum (RPKM 3.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See C4orf33 in Genome Data Viewer
Location:
4q28.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (129093712..129116637)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (132397882..132420798)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (130014867..130037792)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr4:129697052-129697573 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129723780-129724699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129734111-129734692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:129734693-129735274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21898 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:129752609-129753288 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:129753289-129753968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129756920-129757462 Neighboring gene jade family PHD finger 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21899 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21902 Neighboring gene CDRT15 pseudogene 11 Neighboring gene zinc finger SWIM-type containing 5 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
  2. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Hou P, et al. Cancer Res, 2017 Aug 15. PMID 28625976, Free PMC Article
  3. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
  4. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of chromosome 4 open reading frame 33 (C4orf33) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33703

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
UPF0462 protein C4orf33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099783.2 → NP_001093253.1  UPF0462 protein C4orf33

    See identical proteins and their annotated locations for NP_001093253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093826, BC032582, BE566349, BQ549846, BU783470, CN483524
    Consensus CDS
    CCDS3741.1
    UniProtKB/Swiss-Prot
    D3DNY2, Q6PJF3, Q8N1A6, Q8NBC5
    UniProtKB/TrEMBL
    D6RIT3
    Related
    ENSP00000401090.1, ENST00000425929.6
    Conserved Domains (1) summary
    cl14783
    Location:42 → 171
    DOMON_like; Domon-like ligand-binding domains

  2. NM_173487.3 → NP_775758.2  UPF0462 protein C4orf33

    See identical proteins and their annotated locations for NP_775758.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093826, BC032582, BP871612, BQ549846, BU783470
    Consensus CDS
    CCDS3741.1
    UniProtKB/Swiss-Prot
    D3DNY2, Q6PJF3, Q8N1A6, Q8NBC5
    UniProtKB/TrEMBL
    D6RIT3
    Related
    ENSP00000281146.4, ENST00000281146.9
    Conserved Domains (1) summary
    cl14783
    Location:42 → 171
    DOMON_like; Domon-like ligand-binding domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    129093712..129116637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007724.2 → XP_016863213.1  UPF0462 protein C4orf33 isoform X1

    UniProtKB/TrEMBL
    D6RIT3
    Related
    ENSP00000427406.1, ENST00000502887.5
    Conserved Domains (1) summary
    cl14783
    Location:42 → 94
    DOMON_like; Domon-like ligand-binding domains

  2. XM_047449598.1 → XP_047305554.1  UPF0462 protein C4orf33 isoform X1

  3. XM_047449599.1 → XP_047305555.1  UPF0462 protein C4orf33 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    132397882..132420798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348895.1 → XP_054204870.1  UPF0462 protein C4orf33 isoform X1

  2. XM_054348893.1 → XP_054204868.1  UPF0462 protein C4orf33 isoform X1

  3. XM_054348894.1 → XP_054204869.1  UPF0462 protein C4orf33 isoform X2

  4. XM_054348896.1 → XP_054204871.1  UPF0462 protein C4orf33 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N1A6.2 GenPept UniProtKB/Swiss-Prot:Q8N1A6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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