Dlg4 discs large MAGUK scaffold protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dlg4provided by MGI
Official Full Name: discs large MAGUK scaffold protein 4provided by MGI
Primary source: MGI:MGI:1277959
See related: Ensembl:ENSMUSG00000020886 AllianceGenome:MGI:1277959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlgh4; PSD95; SAP90; PSD-95; SAP90A
Summary: Enables ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within protein localization to synapse; regulation of long-term neuronal synaptic plasticity; and synaptic vesicle maturation. Located in several cellular components, including axon; postsynaptic density; and synaptic vesicle. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Colocalizes with postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 161.9), frontal lobe adult (RPKM 143.5) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.96 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69908029..69938107)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70017203..70045535)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperfunction of post-synaptic density protein 95 promotes seizure response in early-stage abeta pathology.
Title: Hyperfunction of post-synaptic density protein 95 promotes seizure response in early-stage aβ pathology.
Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
Title: Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome.
Title: A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome.
Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways.
Title: Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways.
Environmental enrichment alters LPS-induced changes in BDNF and PSD-95 expressions during puberty.
Title: Environmental enrichment alters LPS-induced changes in BDNF and PSD-95 expressions during puberty.
Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling.
Title: Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling.
POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function.
Title: POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function.
PSD-95 protects synapses from beta-amyloid.
Title: PSD-95 protects synapses from β-amyloid.
Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits.
Title: Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits.
Alcohol hangover induces nitric oxide metabolism changes by impairing NMDA receptor-PSD95-nNOS pathway.
Title: Alcohol hangover induces nitric oxide metabolism changes by impairing NMDA receptor-PSD95-nNOS pathway.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (15) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:224404 (e-PCR)
- UniSTS:224404

D11Mit243 (e-PCR), detects polymorphism
- UniSTS:126443

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables D1 dopamine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables P2Y1 nucleotide receptor binding	ISO Inferred from Sequence Orthology more info
enables P2Y1 nucleotide receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-1 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-1 adrenergic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-2 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables neurexin family protein binding	NAS Non-traceable Author Statement more info	PubMed
enables neuroligin family protein binding	ISO Inferred from Sequence Orthology more info
enables neuroligin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in AMPA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in NMDA selective glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to potassium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine organization	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection arborization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in receptor localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
involved_in response to cocaine	NAS Non-traceable Author Statement more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic vesicle maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synaptic vesicle maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cerebellar mossy fiber	IDA Inferred from Direct Assay more info	PubMed
located_in cortical cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic branch	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in neuron spine	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info	PubMed
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in proximal dendrite	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: disks large homolog 4

Names: PSD-95 alpha 2b; PSD-95 beta; SAP-90; discs large homolog 4; discs, large homolog 4; postsynaptic density protein 95; synapse-associated protein 90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109752.1 → NP_001103222.1 disks large homolog 4 isoform 2

See identical proteins and their annotated locations for NP_001103222.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 6. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 6.

Source sequence(s)

BC014807, BQ959940, CA320223

Consensus CDS

CCDS48829.1

UniProtKB/TrEMBL

G3UZL5

Related

ENSMUSP00000156345.2, ENSMUST00000231415.2

Conserved Domains (7) summary

cd12030
Location:427 → 492

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00072
Location:541 → 707

GuKc; Guanylate kinase homologues

smart00228
Location:307 → 391

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:62 → 146

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:530 → 708

Guanylate_kin; Guanylate kinase

pfam10600
Location:242 → 309

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 61

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001370671.1 → NP_001357600.1 disks large homolog 4 isoform 3

Status: VALIDATED

Source sequence(s)

AL596185

UniProtKB/TrEMBL

G3UZL5

Conserved Domains (6) summary

cd12030
Location:435 → 500

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:315 → 399

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00625
Location:538 → 716

Guanylate_kin; Guanylate kinase

pfam10600
Location:250 → 317

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam00595
Location:70 → 154

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam10608
Location:19 → 69

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001370672.1 → NP_001357601.1 disks large homolog 4 isoform 4

Status: VALIDATED

Source sequence(s)

AL596185

Consensus CDS

CCDS88179.1

UniProtKB/TrEMBL

A0A338P6E5, G3UZL5

Conserved Domains (5) summary

cd12030
Location:370 → 435

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:250 → 334

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:5 → 89

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:473 → 651

Guanylate_kin; Guanylate kinase

pfam10600
Location:185 → 252

PDZ_assoc; PDZ-associated domain of NMDA receptors
NM_001370674.1 → NP_001357603.1 disks large homolog 4 isoform 5

Status: VALIDATED

Source sequence(s)

AL596185

UniProtKB/TrEMBL

G3UZL5

Conserved Domains (6) summary

cd12030
Location:406 → 471

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:286 → 370

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00625
Location:509 → 687

Guanylate_kin; Guanylate kinase

pfam10600
Location:221 → 288

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam00595
Location:41 → 125

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam10608
Location:10 → 40

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001370675.1 → NP_001357604.1 disks large homolog 4 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) encodes the longest isoform (6)

Source sequence(s)

AL596185

Consensus CDS

CCDS88178.1

UniProtKB/TrEMBL

A0A338P6I6, G3UZL5

Related

ENSMUSP00000155973.2, ENSMUST00000231506.2

Conserved Domains (7) summary

cd12030
Location:470 → 535

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:350 → 434

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00625
Location:573 → 751

Guanylate_kin; Guanylate kinase

pfam10600
Location:285 → 352

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam00595
Location:105 → 189

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam10608
Location:54 → 104

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl02672
Location:26 → 47

L27; L27 domain
NM_001430918.1 → NP_001417847.1 disks large homolog 4 isoform 7

Status: VALIDATED

Source sequence(s)

AL596185
NM_007864.3 → NP_031890.1 disks large homolog 4 isoform 1

See identical proteins and their annotated locations for NP_031890.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 6. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 6.

Source sequence(s)

BC014807, BI738861, BQ959940, CA320223

Consensus CDS

CCDS36202.1

UniProtKB/Swiss-Prot

Q5NCV5, Q5NCV6, Q5NCV7, Q62108, Q91WJ1

UniProtKB/TrEMBL

G3UZL5

Related

ENSMUSP00000104229.3, ENSMUST00000108588.9

Conserved Domains (7) summary

cd12030
Location:430 → 495

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00072
Location:544 → 710

GuKc; Guanylate kinase homologues

smart00228
Location:310 → 394

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:65 → 149

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:533 → 711

Guanylate_kin; Guanylate kinase

pfam10600
Location:245 → 312

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 64

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69908029..69938107

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156285.1 → XP_036012178.1 disks large homolog 4 isoform X1

UniProtKB/TrEMBL

G3UZL5

Conserved Domains (6) summary

cd12030
Location:463 → 528

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:343 → 427

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:98 → 182

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:566 → 744

Guanylate_kin; Guanylate kinase

pfam10600
Location:278 → 345

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 97

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006532144.3 → XP_006532207.1 disks large homolog 4 isoform X2

See identical proteins and their annotated locations for XP_006532207.1

UniProtKB/TrEMBL

G3UZL5

Conserved Domains (6) summary

cd12030
Location:460 → 525

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:340 → 424

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:95 → 179

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:563 → 741

Guanylate_kin; Guanylate kinase

pfam10600
Location:275 → 342

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 94

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006532148.3 → XP_006532211.1 disks large homolog 4 isoform X4

See identical proteins and their annotated locations for XP_006532211.1

UniProtKB/TrEMBL

G3UZL5

Conserved Domains (6) summary

cd12030
Location:408 → 473

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:288 → 372

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:43 → 127

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:511 → 689

Guanylate_kin; Guanylate kinase

pfam10600
Location:223 → 290

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:11 → 42

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006532150.3 → XP_006532213.1 disks large homolog 4 isoform X5

Conserved Domains (6) summary

cd12030
Location:405 → 470

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:285 → 369

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:40 → 124

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:508 → 686

Guanylate_kin; Guanylate kinase

pfam10600
Location:220 → 287

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:11 → 39

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_036156286.1 → XP_036012179.1 disks large homolog 4 isoform X6

UniProtKB/TrEMBL

A0A338P6E5, G3UZL5

Related

ENSMUSP00000018700.8, ENSMUST00000018700.14

Conserved Domains (5) summary

cd12030
Location:370 → 435

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:250 → 334

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:5 → 89

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:473 → 651

Guanylate_kin; Guanylate kinase

pfam10600
Location:185 → 252

PDZ_assoc; PDZ-associated domain of NMDA receptors
XM_006532147.5 → XP_006532210.3 disks large homolog 4 isoform X3

UniProtKB/TrEMBL

G3UZL5

Conserved Domains (6) summary

cd12030
Location:409 → 474

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:289 → 373

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:44 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:512 → 690

Guanylate_kin; Guanylate kinase

pfam10600
Location:224 → 291

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:8 → 43

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK