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LMXM_29_0340 putative KU80 protein [ Leishmania mexicana MHOM/GT/2001/U1103 ]

Gene ID: 13451655, updated on 30-Oct-2024

Summary

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Gene symbol
LMXM_29_0340
Gene description
putative KU80 protein
Locus tag
LMXM_29_0340
Gene type
protein coding
RNA name
putative KU80 protein
RefSeq status
PROVISIONAL
Organism
Leishmania mexicana MHOM/GT/2001/U1103 (strain: MHOM/GT/2001/U1103)
Lineage
Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania
Orthologs
Leishmania major all
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Genomic context

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See LMXM_29_0340 in Genome Data Viewer
Location:
chromosome: 29
Exon count:
1
Sequence:
Chromosome: 29; NC_018333.1 (104688..107084, complement)

Chromosome 29 - NC_018333.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene putative kinesin Neighboring gene putative endosomal integral membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_018333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana. Poláková E, et al. PLoS Negl Trop Dis, 2021 Dec. PMID 34965251, Free PMC Article
  2. Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Rogers MB, et al. Genome Res, 2011 Dec. PMID 22038252, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana.
    Title: Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to X-ray IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Ku70:Ku80 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Names
putative KU80 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_018333.1 Reference assembly

    Range
    104688..107084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003877131.1 → XP_003877180.1  putative KU80 protein [Leishmania mexicana MHOM/GT/2001/U1103]

    See identical proteins and their annotated locations for XP_003877180.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    E9B0F8
    Conserved Domains (3) summary
    cd00873
    Location:245 → 546
    KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
    pfam08785
    Location:650 → 773
    Ku_PK_bind; Ku C terminal domain like
    cl00057
    Location:30 → 188
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
Heading Accession and Version

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