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Catalase impairs Leishmania mexicana development and virulence.
Title: Catalase impairs Leishmania mexicana development and virulence.
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Constitutive nitric oxide synthase-like enzyme in two species involved in cutaneous and mucocutaneous leishmaniasis.
Title: Constitutive nitric oxide synthase-like enzyme in two species involved in cutaneous and mucocutaneous leishmaniasis.
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A cytoskeletal protein complex is essential for division of intracellular amastigotes of Leishmania mexicana.
Title: A cytoskeletal protein complex is essential for division of intracellular amastigotes of Leishmania mexicana.
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Essential roles for deubiquitination in Leishmania life cycle progression.
Title: Essential roles for deubiquitination in Leishmania life cycle progression.
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Although the LeishIF4E1(-/-) null mutant was viable, its growth was impaired, in line with a reduction in global translation. As a result of the mutation, the null LeishIF4E1(-/-) mutant had a defective morphology, as the cells were round and unable to grow a normal flagellum.[eIF4E1]
Title: LeishIF4E1 Deletion Affects the Promastigote Proteome, Morphology, and Infectivity.
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The importance of this study is in highlighting that LeishIF4E-3 is essential for completion of the parasite life cycle [IF4E-3].
Title: Deletion of a Single LeishIF4E-3 Allele by the CRISPR-Cas9 System Alters Cell Morphology and Infectivity of Leishmania.
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Data suggest that SodA of Leishmania mexicana amazonensis is a mitochondrial isoenzyme that promotes virulence and is essential for trypanosomatid survival; SodA appears to promote virulence by protecting parasites against mitochondrion generated oxidative stress and by initiating ROS-mediated signaling mechanisms required for differentiation of infective forms. [SodA, iron-dependent superoxide dismutase]
Title: The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence.
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Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.
Title: Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.
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these null mutants are completely avirulent following injection into BALB/c mice, underscoring the critical role of the KHARON1 protein for viability of intracellular amastigotes and disease in the animal model of leishmaniasis.
Title: Kharon1 null mutants of Leishmania mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages.
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The cysteine of the unique HDCF loop is indispensable for catalytic activity of the sterol carrier protein-2. [Scp2 protein, Leishmania mexicana]
Title: Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop.