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Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic [ Mus musculus (house mouse) ]

Gene ID: 13480, updated on 27-Nov-2024

Summary

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Official Symbol
Dpm1provided by MGI
Official Full Name
dolichyl-phosphate mannosyltransferase subunit 1, catalyticprovided by MGI
Primary source
MGI:MGI:1330239
See related
Ensembl:ENSMUSG00000078919 AllianceGenome:MGI:1330239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables dolichyl-phosphate beta-D-mannosyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process; dolichol metabolic process; and response to oxygen levels. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 5.1), bladder adult (RPKM 4.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dpm1 in Genome Data Viewer
Location:
2 H3; 2 88.46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168050968..168072299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168209048..168230379, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54130 Neighboring gene predicted gene 20716 Neighboring gene activity-dependent neuroprotective protein Neighboring gene STARR-seq mESC enhancer starr_06457 Neighboring gene STARR-positive B cell enhancer ABC_E10163 Neighboring gene STARR-positive B cell enhancer ABC_E8797 Neighboring gene STARR-seq mESC enhancer starr_06458 Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ebz of NZW mice is identical with Ebu of B10.PL mice. Nishimura H, et al. Immunogenetics, 1991. PMID 2050394
  2. Nucleotide sequence analysis of MHC class II genes in autoimmune disease-prone (NZB x NZW)F1 mice. Ogawa S, et al. Immunogenetics, 1990. PMID 2165036
  3. Disrupting KATP channels diminishes the estrogen-mediated protection in female mutant mice during ischemia-reperfusion. Gao J, et al. Clin Proteomics, 2014. PMID 24936167, Free PMC Article
  4. A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. Tomita S, et al. J Biol Chem, 1998 Apr 10. PMID 9535917
  5. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Mallakin A, et al. Cancer Cell, 2007 Oct. PMID 17936562, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Gm20716

Readthrough gene: Gm20716, Included gene: Adnp

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-mannose binding IEA
Inferred from Electronic Annotation
more info
  
enables D-mannose binding ISO
Inferred from Sequence Orthology
more info
  
enables alcohol binding IEA
Inferred from Electronic Annotation
more info
  
enables alcohol binding ISO
Inferred from Sequence Orthology
more info
  
enables dolichyl-phosphate beta-D-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl-phosphate beta-D-mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dolichyl-phosphate beta-D-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables dolichyl-phosphate beta-D-mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within dolichol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol phosphate mannose biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein mannosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to oxygen levels IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of dolichol-phosphate-mannose synthase complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dolichol-phosphate mannosyltransferase subunit 1
Names
DPM synthase subunit 1
MPD synthase
dolichol-phosphate (beta-D) mannosyltransferase 1
dolichol-phosphate mannose synthase subunit 1
dolichyl-phosphate beta-D-mannosyltransferase subunit 1
mannose-P-dolichol synthase subunit 1
NP_001297013.1
NP_034202.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310084.1 → NP_001297013.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK004834, BF019794, BM941163, BX005039
    UniProtKB/Swiss-Prot
    O70152
    Conserved Domains (2) summary
    cd06442
    Location:29 → 233
    DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
    PLN02726
    Location:21 → 237
    PLN02726; dolichyl-phosphate beta-D-mannosyltransferase

  2. NM_010072.4 → NP_034202.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_034202.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK005268, BM941163, BX005039
    Consensus CDS
    CCDS17109.1
    UniProtKB/Swiss-Prot
    O70152, Q9D829
    Related
    ENSMUSP00000118776.2, ENSMUST00000154111.8
    Conserved Domains (2) summary
    cd06442
    Location:29 → 256
    DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
    PLN02726
    Location:21 → 260
    PLN02726; dolichyl-phosphate beta-D-mannosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    168050968..168072299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70152.1 GenPept UniProtKB/Swiss-Prot:O70152

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