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TAAR9 trace amine associated receptor 9 [ Homo sapiens (human) ]

Gene ID: 134860, updated on 27-Nov-2024

Summary

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Official Symbol
TAAR9provided by HGNC
Official Full Name
trace amine associated receptor 9provided by HGNC
Primary source
HGNC:HGNC:20977
See related
Ensembl:ENSG00000237110 MIM:608282; AllianceGenome:HGNC:20977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TA3; TAR3; TAR9; TRAR3
Summary
TAAR9 is a member of a large family of rhodopsin G protein-coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Jul 2005]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Orthologs
all
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Genomic context

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See TAAR9 in Genome Data Viewer
Location:
6q23.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132538277..132539336)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133733231..133734290)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132859416..132860475)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene syntaxin 7 Neighboring gene Sharpr-MPRA regulatory region 15532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25071 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:132833503-132834004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25072 Neighboring gene ribosomal protein L21 pseudogene 66 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:132848222-132849421 Neighboring gene trace amine associated receptor 8 Neighboring gene trace amine associated receptor 7, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Discovery of a null mutation in a human trace amine receptor gene. Vanti WB, et al. Genomics, 2003 Nov. PMID 14559210
  2. Correlation of a set of gene variants, life events and personality features on adult ADHD severity. Müller DJ, et al. J Psychiatr Res, 2010 Jul. PMID 20006992
  3. A second class of chemosensory receptors in the olfactory epithelium. Liberles SD, et al. Nature, 2006 Aug 10. PMID 16878137
  4. Trace amines: identification of a family of mammalian G protein-coupled receptors. Borowsky B, et al. Proc Natl Acad Sci U S A, 2001 Jul 31. PMID 11459929, Free PMC Article
  5. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Lindemann L, et al. Genomics, 2005 Mar. PMID 15718104

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables trace-amine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables trace-amine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sensory perception of smell ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
trace amine-associated receptor 9
Names
trace amine receptor 3
trace amine receptor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175057.4 → NP_778227.3  trace amine-associated receptor 9

    See identical proteins and their annotated locations for NP_778227.3

    Status: VALIDATED

    Source sequence(s)
    AL513524, KF459634
    Consensus CDS
    CCDS75520.1
    UniProtKB/Swiss-Prot
    Q96RI9
    Related
    ENSP00000424607.2, ENST00000434551.3
    Conserved Domains (2) summary
    pfam00001
    Location:49 → 311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:43 → 271
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    132538277..132539336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    133733231..133734290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RI9.1 GenPept UniProtKB/Swiss-Prot:Q96RI9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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