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Caln1 calneuron 1 [ Mus musculus (house mouse) ]

Gene ID: 140904, updated on 27-Nov-2024

Summary

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Official Symbol
Caln1provided by MGI
Official Full Name
calneuron 1provided by MGI
Primary source
MGI:MGI:2155987
See related
Ensembl:ENSMUSG00000060371 AllianceGenome:MGI:2155987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cabp8; MNCb-0849; 9630012C17Rik
Summary
Predicted to enable calcium ion binding activity. Located in trans-Golgi network membrane. Is expressed in central nervous system and retina. Orthologous to human CALN1 (calneuron 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 19.5), cortex adult (RPKM 8.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Caln1 in Genome Data Viewer
Location:
5 G1.3- G2; 5 69.29 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130398245..130876253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130369404..130846325)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:130730118-130730418 Neighboring gene STARR-positive B cell enhancer ABC_E234 Neighboring gene STARR-positive B cell enhancer ABC_E279 Neighboring gene STARR-seq mESC enhancer starr_14473 Neighboring gene RIKEN cDNA A330070K13 gene Neighboring gene SBDS ribosome maturation factor Neighboring gene STARR-seq mESC enhancer starr_14474 Neighboring gene tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_14475 Neighboring gene STARR-seq mESC enhancer starr_14476 Neighboring gene predicted gene, 40336 Neighboring gene STARR-seq mESC enhancer starr_14477 Neighboring gene STARR-seq mESC enhancer starr_14478 Neighboring gene predicted gene, 40337 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 17 Neighboring gene STARR-seq mESC enhancer starr_14479 Neighboring gene predicted gene, 40338

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses. Andres-Alonso M, et al. Cell Rep, 2023 Jul 25. PMID 37355986
  2. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Haeseleer F, et al. Adv Exp Med Biol, 2002. PMID 12596929
  3. Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily. Wu YQ, et al. Mol Genet Metab, 2001 Apr. PMID 11286509
  4. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. McCue HV, et al. Biochem Biophys Res Commun, 2009 Mar 20. PMID 19338761, Free PMC Article
  5. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Pereira JD, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20798045, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium-binding protein 8
Names
calneuron I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021371.2 → NP_067346.1  calcium-binding protein 8 isoform b

    See identical proteins and their annotated locations for NP_067346.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    BC058963, BY274079
    Consensus CDS
    CCDS19714.1
    UniProtKB/TrEMBL
    Q542R1, Q8CBJ9
    Related
    ENSMUSP00000106919.3, ENSMUST00000111288.4
    Conserved Domains (1) summary
    PTZ00184
    Location:32 → 142
    PTZ00184; calmodulin; Provisional

  2. NM_181045.2 → NP_851388.1  calcium-binding protein 8 isoform a

    See identical proteins and their annotated locations for NP_851388.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AC113029, AC120437, AC142405, AC156620
    Consensus CDS
    CCDS51656.1
    UniProtKB/Swiss-Prot
    F8WHE1, Q9JJG7
    UniProtKB/TrEMBL
    Q8CBJ9
    Related
    ENSMUSP00000083193.4, ENSMUST00000086029.10
    Conserved Domains (3) summary
    cd00051
    Location:82 → 143
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd15899
    Location:82 → 109
    EFh_CREC; EF-hand motif [structural motif]
    cl25354
    Location:65 → 189
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    130398245..130876253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164786.1 → XP_036020679.1  calcium-binding protein 8 isoform X4

    UniProtKB/Swiss-Prot
    F8WHE1, Q9JJG7
    UniProtKB/TrEMBL
    Q8CBJ9
    Conserved Domains (3) summary
    cd00051
    Location:82 → 143
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd15899
    Location:82 → 109
    EFh_CREC; EF-hand motif [structural motif]
    cl25354
    Location:65 → 189
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

  2. XM_006504369.4 → XP_006504432.1  calcium-binding protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006504432.1

    UniProtKB/TrEMBL
    Q8CBJ9
    Conserved Domains (1) summary
    PTZ00184
    Location:84 → 194
    PTZ00184; calmodulin; Provisional

  3. XM_006504367.4 → XP_006504430.1  calcium-binding protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006504430.1

    UniProtKB/TrEMBL
    Q8CBJ9
    Conserved Domains (1) summary
    PTZ00184
    Location:84 → 194
    PTZ00184; calmodulin; Provisional

  4. XM_006504372.5 → XP_006504435.1  calcium-binding protein 8 isoform X4

    See identical proteins and their annotated locations for XP_006504435.1

    UniProtKB/Swiss-Prot
    F8WHE1, Q9JJG7
    UniProtKB/TrEMBL
    Q8CBJ9
    Conserved Domains (3) summary
    cd00051
    Location:82 → 143
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd15899
    Location:82 → 109
    EFh_CREC; EF-hand motif [structural motif]
    cl25354
    Location:65 → 189
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

  5. XM_006504368.5 → XP_006504431.1  calcium-binding protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006504431.1

    UniProtKB/TrEMBL
    Q8CBJ9
    Conserved Domains (1) summary
    PTZ00184
    Location:84 → 194
    PTZ00184; calmodulin; Provisional

  6. XM_036164784.1 → XP_036020677.1  calcium-binding protein 8 isoform X2

    UniProtKB/TrEMBL
    Q8CBJ9
    Conserved Domains (1) summary
    PTZ00184
    Location:84 → 194
    PTZ00184; calmodulin; Provisional

  7. XM_006504374.2 → XP_006504437.1  calcium-binding protein 8 isoform X5

    See identical proteins and their annotated locations for XP_006504437.1

    UniProtKB/TrEMBL
    Q542R1, Q8CBJ9
    Conserved Domains (1) summary
    PTZ00184
    Location:32 → 142
    PTZ00184; calmodulin; Provisional

  8. XM_006504373.3 → XP_006504436.1  calcium-binding protein 8 isoform X5

    See identical proteins and their annotated locations for XP_006504436.1

    UniProtKB/TrEMBL
    Q542R1, Q8CBJ9
    Related
    ENSMUSP00000106918.2, ENSMUST00000111287.8
    Conserved Domains (1) summary
    PTZ00184
    Location:32 → 142
    PTZ00184; calmodulin; Provisional

  9. XM_006504366.4 → XP_006504429.3  calcium-binding protein 8 isoform X1

    Conserved Domains (1) summary
    PTZ00184
    Location:87 → 197
    PTZ00184; calmodulin; Provisional

  10. XM_036164785.1 → XP_036020678.1  calcium-binding protein 8 isoform X3

    UniProtKB/TrEMBL
    Q8CBJ9
    Conserved Domains (1) summary
    PTZ00184
    Location:84 → 194
    PTZ00184; calmodulin; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJG7.2 GenPept UniProtKB/Swiss-Prot:Q9JJG7

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