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Fgf5 fibroblast growth factor 5 [ Mus musculus (house mouse) ]

Gene ID: 14176, updated on 27-Nov-2024

Summary

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Official Symbol
Fgf5provided by MGI
Official Full Name
fibroblast growth factor 5provided by MGI
Primary source
MGI:MGI:95519
See related
Ensembl:ENSMUSG00000029337 AllianceGenome:MGI:95519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
go; Fgf-5; Fgf3a; HBGF-5; angora
Summary
This gene encodes a secreted protein that is a member of a family of heparin-binding growth factors. The encoded protein regulates cell proliferation, particularly the growth of hair follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Fgf5 in Genome Data Viewer
Location:
5 E3; 5 47.77 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (98402108..98424892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (98254184..98277033)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730035I17 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene PR domain containing 8 Neighboring gene STARR-seq mESC enhancer starr_13701 Neighboring gene cilia and flagella associated protein 299 Neighboring gene predicted gene, 34475 Neighboring gene microRNA 703

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fibroblast growth factor-5 participates in the progression of hepatic fibrosis. Hanaka H, et al. Exp Anim, 2014. PMID 24521867, Free PMC Article
  2. Decapeptide with fibroblast growth factor (FGF)-5 partial sequence inhibits hair growth suppressing activity of FGF-5. Ito C, et al. J Cell Physiol, 2003 Nov. PMID 14502567
  3. Fibroblast growth factor-5 is expressed in Schwann cells and is not essential for motoneurone survival. McGeachie AB, et al. Neuroscience, 2001. PMID 11440818
  4. Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair. Mizuno S, et al. Exp Anim, 2011. PMID 21512271
  5. Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression. Sundberg JP, et al. Vet Pathol, 1997 May. PMID 9163872

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.
    Title: FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.
  2. Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.
    Title: Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.
  3. SP1-induced lncRNA TUG1 regulates proliferation and apoptosis in islet cells of type 2 diabetes mellitus via the miR-188-3p/FGF5 axis.
    Title: SP1-induced lncRNA TUG1 regulates proliferation and apoptosis in islet cells of type 2 diabetes mellitus via the miR-188-3p/FGF5 axis.
  4. Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
    Title: Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
  5. Etv5 can positively regulate primitive endoderm specification through regulating Gata6 and negatively regulate epiblast specification by inhibiting Fgf5 expression.
    Title: The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.
  6. Recruited CD11b+ CD68+ Kupffer cells/Mphis may play an essential role in steatohepatitis and fibrosis in FGF5 null mice fed with a HFD. Recruitment and activation of bone marrow derived Mphis is the key factor to develop steatohepatitis from simple steatosis.
    Title: Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.
  7. It participates in the progression of hepatic fibrosis.
    Title: Fibroblast growth factor-5 participates in the progression of hepatic fibrosis.
  8. Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice
    Title: [Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice].
  9. A deletion of a 9.3-kb region in the Fgf5 gene showed insertion of a 498-bp early transposon element long terminal repeat. Results show that long hair mutation of moja/moja mice is caused by Fgf5 disruption mediated by retrotransposon insertion.
    Title: Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair.
  10. Fluctuations of BMP2 signaling pathway during hair cycles in skin with mutant genes we, wal and Fgf5(go).
    Title: Fluctuations of BMP signaling pathway during hair cycles in skin of mice with mutant genes we, wal and Fgf5(go).
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibroblast growth factor 5
Names
fibroblast growth factor 3a
heparin-binding growth factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277268.2 → NP_001264197.1  fibroblast growth factor 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001264197.1

    Status: VALIDATED

    Source sequence(s)
    AC125073
    Consensus CDS
    CCDS80344.1
    UniProtKB/Swiss-Prot
    P15656
    Related
    ENSMUSP00000142420.2, ENSMUST00000200059.2
    Conserved Domains (1) summary
    cl00060
    Location:85 → 114
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  2. NM_010203.6 → NP_034333.1  fibroblast growth factor 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034333.1

    Status: VALIDATED

    Source sequence(s)
    AC125073
    Consensus CDS
    CCDS19455.1
    UniProtKB/Swiss-Prot
    O88825, P15656
    UniProtKB/TrEMBL
    A0A7U3L698
    Related
    ENSMUSP00000031280.2, ENSMUST00000031280.2
    Conserved Domains (1) summary
    pfam00167
    Location:85 → 214
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    98402108..98424892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15656.1 GenPept UniProtKB/Swiss-Prot:P15656

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