SLC2A14 solute carrier family 2 member 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC2A14provided by HGNC
Official Full Name: solute carrier family 2 member 14provided by HGNC
Primary source: HGNC:HGNC:18301
See related: Ensembl:ENSG00000173262 MIM:611039; AllianceGenome:HGNC:18301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLUT14; SLC2A3P3
Summary: Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]
Expression: Biased expression in testis (RPKM 31.0), bone marrow (RPKM 13.8) and 5 other tissues See more
Orthologs: all
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Genomic context

Location:: 12p13.31

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (7812514..7891196, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (7827112..7905386, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (7965110..8043792, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Under hypoxia and HIF1 blockade, cancer cells adapt their energy metabolism via upregulation of the GLUT14 glucose transporter and creatine metabolism providing new avenues for drug targeting.
Title: Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.
Three alleles in the SLC2A14 gene associated independently with inflammatory bowel disease.
Title: The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.
report presents an expanded SLC2A14 gene locus and a more diverse tissue expression, concurring with the existing evidence for disease associations
Title: The SLC2A14 gene: genomic locus, tissue expression, splice variants, and subcellular localization of the protein.
High expression of GLUT-14 was associated with Gastric Adenocarcinoma.
Title: Both GLUT-1 and GLUT-14 are Independent Prognostic Factors in Gastric Adenocarcinoma.
SLC2A14 polymorphism has a possible role in changing the genetic susceptibility to late Alzheimer disease age of onset in a Han Chinese population.
Title: Genetic association of SLC2A14 polymorphism with Alzheimer's disease in a Han Chinese population.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-30912 (e-PCR)
- UniSTS:11589

WI-20968 (e-PCR)
- UniSTS:23386

SHGC-31620 (e-PCR)
- UniSTS:26485

RH65076 (e-PCR)
- UniSTS:92820

G10588 (e-PCR)
- UniSTS:47035

RH78158 (e-PCR)
- UniSTS:29404

SHGC-154853 (e-PCR)
- UniSTS:183546

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in aggresome	IDA Inferred from Direct Assay more info
located_in nucleus	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 14

Names: glucose transporter type 14; solute carrier family 2 (facilitated glucose transporter), member 14; solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286233.2 → NP_001273162.1 solute carrier family 2, facilitated glucose transporter member 14 isoform a

See identical proteins and their annotated locations for NP_001273162.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC006517, AK126026, AY357941, BC060766, DB061127, DB062960, DB069339, DB082816

Consensus CDS

CCDS8585.1

UniProtKB/Swiss-Prot

B3KVB5, B3KWW7, B7Z844, B7ZAC3, Q6UY84, Q8TDB8, Q8TDB9

UniProtKB/TrEMBL

B7Z5J8

Related

ENSP00000440480.1, ENST00000543909.5

Conserved Domains (2) summary

cd06174
Location:38 → 472

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:39 → 489

Sugar_tr; Sugar (and other) transporter
NM_001286234.2 → NP_001273163.1 solute carrier family 2, facilitated glucose transporter member 14 isoform b

See identical proteins and their annotated locations for NP_001273163.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).

Source sequence(s)

AC006517, AY357941, BC060766, DB069339, DB082816

Consensus CDS

CCDS66301.1

UniProtKB/TrEMBL

B7Z5J8

Related

ENSP00000407287.2, ENST00000431042.7

Conserved Domains (1) summary

cd17431
Location:13 → 457

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
NM_001286235.2 → NP_001273164.1 solute carrier family 2, facilitated glucose transporter member 14 isoform b

See identical proteins and their annotated locations for NP_001273164.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).

Source sequence(s)

AC006517, AK122783, AY357941, BC060766, BG717327, DB069339, DB082816

Consensus CDS

CCDS66301.1

UniProtKB/TrEMBL

B7Z5J8

Related

ENSP00000340450.5, ENST00000340749.9

Conserved Domains (1) summary

cd17431
Location:13 → 457

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
NM_001286236.2 → NP_001273165.1 solute carrier family 2, facilitated glucose transporter member 14 isoform c

See identical proteins and their annotated locations for NP_001273165.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate downstream start codon. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AC006517, AK302881, AY357941, BC060766, DB069339, DB082816

Consensus CDS

CCDS66300.1

UniProtKB/TrEMBL

B7Z5A7

Related

ENSP00000440492.1, ENST00000535295.5

Conserved Domains (2) summary

cd06174
Location:5 → 363

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:5 → 380

Sugar_tr; Sugar (and other) transporter
NM_001286237.2 → NP_001273166.1 solute carrier family 2, facilitated glucose transporter member 14 isoform d

See identical proteins and their annotated locations for NP_001273166.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is longer than isoform a.

Source sequence(s)

AC006517, AC007536

Consensus CDS

CCDS66302.1

UniProtKB/TrEMBL

B7Z5J8

Related

ENSP00000445929.1, ENST00000539924.5

Conserved Domains (2) summary

cd06174
Location:53 → 487

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:54 → 504

Sugar_tr; Sugar (and other) transporter
NM_153449.4 → NP_703150.1 solute carrier family 2, facilitated glucose transporter member 14 isoform a

See identical proteins and their annotated locations for NP_703150.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC006517, AF481879, AY357941, BC060766, DB069339

Consensus CDS

CCDS8585.1

UniProtKB/Swiss-Prot

B3KVB5, B3KWW7, B7Z844, B7ZAC3, Q6UY84, Q8TDB8, Q8TDB9

UniProtKB/TrEMBL

B7Z5J8

Related

ENSP00000379834.2, ENST00000396589.6

Conserved Domains (2) summary

cd06174
Location:38 → 472

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:39 → 489

Sugar_tr; Sugar (and other) transporter