Gc vitamin D binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gcprovided by MGI
Official Full Name: vitamin D binding proteinprovided by MGI
Primary source: MGI:MGI:95669
See related: Ensembl:ENSMUSG00000035540 AllianceGenome:MGI:95669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DBP; VDB
Summary: Predicted to enable actin binding activity and calcidiol binding activity. Acts upstream of or within vitamin D metabolic process. Predicted to be located in axon; extracellular space; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; hemolymphoid system gland; liver; male reproductive gland or organ; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 914.3), liver E18 (RPKM 860.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 44.32 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (89565370..89605757, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (89417511..89457898, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GC-Globulin/Vitamin D-Binding Protein Is Required for Pancreatic alpha-Cell Adaptation to Metabolic Stress.
Title: GC-Globulin/Vitamin D-Binding Protein Is Required for Pancreatic α-Cell Adaptation to Metabolic Stress.
The essential role of DBP in the utilization of vitamin D produced in skin by UVB irradiation and presumably sunlight.
Title: Vitamin D binding protein is required to utilize skin-generated vitamin D.
the levels of trisialylated triantennary glycans of haptoglobin and vitamin D-binding protein increased significantly as liver cancer disease progressed, while the alteration in these protein levels were modest.
Title: Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM mice.
results show DBP is a significant chemotactic cofactor in vivo and not specific for C5a, suggesting that this ubiquitous plasma protein may have a more significant role in neutrophil recruitment than previously recognized
Title: Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice.
Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes.
Title: Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes.
Data suggest that whereas DBP is important to total circulating 1,25(OH)(2)D(3) and sequesters extracellular levels of this hormone both in vivo and in vitro, the binding protein does not influence the hormone's biologically active pool.
Title: Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gc (e-PCR), detects polymorphism
- UniSTS:143183

Gc (e-PCR), detects polymorphism
- UniSTS:532425

17.MMHAP32FLF2.seq (e-PCR)
- UniSTS:123338

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcidiol binding	IEA Inferred from Electronic Annotation more info
enables calcidiol binding	ISO Inferred from Sequence Orthology more info
enables vitamin D binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin D binding	ISO Inferred from Sequence Orthology more info
enables vitamin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in vitamin D metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vitamin D metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vitamin D-binding protein

Names: gc-globulin; group specific component

NP_032122.1

EC 6.3.1.5

EC 6.4.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.