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Gfap glial fibrillary acidic protein [ Mus musculus (house mouse) ]

Gene ID: 14580, updated on 27-Nov-2024

Summary

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Official Symbol
Gfapprovided by MGI
Official Full Name
glial fibrillary acidic proteinprovided by MGI
Primary source
MGI:MGI:95697
See related
Ensembl:ENSMUSG00000020932 AllianceGenome:MGI:95697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
A structural constituent of cytoskeleton. Involved in regulation of chaperone-mediated autophagy. Acts upstream of or within with a positive effect on D-aspartate import across plasma membrane; gene expression; and intracellular protein transport. Acts upstream of or within several processes, including long-term synaptic potentiation; neurogenesis; and positive regulation of Schwann cell proliferation. Located in several cellular components, including astrocyte end-foot; cell body; and intermediate filament. Is expressed in several structures, including alimentary system; hemolymphoid system; integumental system; nervous system; and sensory organ. Used to study Alexander disease. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 34.4), frontal lobe adult (RPKM 32.7) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Gfap in Genome Data Viewer
Location:
11 E1; 11 66.48 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102778162..102791368, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102887336..102897200, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102742482-102742665 Neighboring gene coiled-coil domain containing 103 Neighboring gene family with sequence similarity 187, member A Neighboring gene predicted gene, 34560 Neighboring gene kinesin family member 18B Neighboring gene STARR-seq mESC enhancer starr_30821 Neighboring gene complement component 1, q subcomponent-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males. Butruille L, et al. Front Endocrinol (Lausanne), 2022. PMID 35370973, Free PMC Article
  2. Neocortical and hippocampal glial fibrillary acidic protein immunoreactivity shows region-specific variation during the mouse estrous cycle. Struble RG, et al. Neuroendocrinology, 2006. PMID 16926532
  3. Neurons induce GFAP gene promoter of cultured astrocytes from transgenic mice. Gomes FC, et al. Glia, 1999 Apr. PMID 10384875
  4. Accumulation of citrullinated glial fibrillary acidic protein in a mouse model of bile duct ligation-induced hepatic fibrosis. Kim SE, et al. PLoS One, 2018. PMID 30071078, Free PMC Article
  5. Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. Nakashima K, et al. J Neurosci, 1999 Jul 1. PMID 10377352, Free PMC Article

See all (1000) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Astrocyte S100beta expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model.
    Title: Astrocyte S100β expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model.
  2. Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer's disease.
    Title: Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer's disease.
  3. Fate Specification of GFAP-Negative Primitive Neural Stem Cells and Their Progeny at Clonal Resolution.
    Title: Fate Specification of GFAP-Negative Primitive Neural Stem Cells and Their Progeny at Clonal Resolution.
  4. STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.
    Title: STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.
  5. GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming.
    Title: GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming.
  6. Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males.
    Title: Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males.
  7. RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Muller glial cell hypertrophy in progressive retinal degeneration.
    Title: RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Müller glial cell hypertrophy in progressive retinal degeneration.
  8. Evaluation of Traumatic Spinal Cord Injury in a Rat Model Using (99m)Tc-GA-5 as a Potential In Vivo Tracer.
    Title: Evaluation of Traumatic Spinal Cord Injury in a Rat Model Using (99m)Tc-GA-5 as a Potential In Vivo Tracer.
  9. Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: epigenetic modifications of BDNF and GFAP promotors.
    Title: Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: epigenetic modifications of BDNF and GFAP promotors.
  10. Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury.
    Title: Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury.
Submit: New GeneRIF Correction See all GeneRIFs (106)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect D-aspartate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of Schwann cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within astrocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intermediate filament organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intermediate filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intermediate filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within intermediate filament-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron projection regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Schwann cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chaperone-mediated autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chaperone-mediated autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in astrocyte end-foot IDA
Inferred from Direct Assay
more info
 PubMed 
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasmic side of lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glial cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath HDA PubMed 

General protein information

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Preferred Names
glial fibrillary acidic protein
Names
intermediate filament protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131020.1 → NP_001124492.1  glial fibrillary acidic protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK140151, BC139357, BU700210
    Consensus CDS
    CCDS48950.1
    UniProtKB/Swiss-Prot
    P03995
    Related
    ENSMUSP00000077061.5, ENSMUST00000077902.5
    Conserved Domains (2) summary
    pfam00038
    Location:65 → 373
    Filament; Intermediate filament protein
    pfam04732
    Location:4 → 63
    Filament_head; Intermediate filament head (DNA binding) region

  2. NM_010277.3 → NP_034407.2  glial fibrillary acidic protein isoform 2

    See identical proteins and their annotated locations for NP_034407.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus when compared to isoform 1.
    Source sequence(s)
    AI835063, AK079577, BC139357, BE651678, CX223233
    Consensus CDS
    CCDS25507.1
    UniProtKB/Swiss-Prot
    A1E2H7, A2AH87, B2RTI7, P03995, Q09J71, Q3USS4, Q496R4, Q496S3, Q7TQ30, Q80VX6, Q925K2, Q925K3
    Related
    ENSMUSP00000064691.4, ENSMUST00000067444.10
    Conserved Domains (2) summary
    pfam00038
    Location:65 → 373
    Filament; Intermediate filament protein
    pfam04732
    Location:4 → 63
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102778162..102791368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245571.2 → XP_030101431.1  glial fibrillary acidic protein isoform X1

    Conserved Domains (2) summary
    pfam00038
    Location:65 → 373
    Filament; Intermediate filament protein
    pfam04732
    Location:4 → 63
    Filament_head; Intermediate filament head (DNA binding) region

RNA

  1. XR_388347.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03995.4 GenPept UniProtKB/Swiss-Prot:P03995

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools