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Gnao1 guanine nucleotide binding protein, alpha O [ Mus musculus (house mouse) ]

Gene ID: 14681, updated on 27-Nov-2024

Summary

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Official Symbol
Gnao1provided by MGI
Official Full Name
guanine nucleotide binding protein, alpha Oprovided by MGI
Primary source
MGI:MGI:95775
See related
Ensembl:ENSMUSG00000031748 AllianceGenome:MGI:95775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gnao; Hg1g; alphaO; Galphao
Summary
Enables G protein activity and GTP binding activity. Involved in negative regulation of insulin secretion and postsynaptic modulation of chemical synaptic transmission. Acts upstream of with a negative effect on vesicle docking involved in exocytosis. Acts upstream of or within G protein-coupled dopamine receptor signaling pathway; locomotory behavior; and regulation of heart contraction. Located in cell body and dendrite. Is active in several cellular components, including GABA-ergic synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Used to study developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 40.0), frontal lobe adult (RPKM 39.2) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Gnao1 in Genome Data Viewer
Location:
8 C5; 8 45.94 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94537213..94696016)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93810153..93969388)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26843 Neighboring gene predicted gene, 30606 Neighboring gene STARR-seq mESC enhancer starr_22342 Neighboring gene predicted gene, 39224 Neighboring gene RIKEN cDNA 4930488L21 gene Neighboring gene STARR-seq mESC enhancer starr_22343 Neighboring gene STARR-seq mESC enhancer starr_22344 Neighboring gene VISTA enhancer mm1458 Neighboring gene predicted gene, 53411 Neighboring gene autocrine motility factor receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96561142-96561251 Neighboring gene nudix hydrolase 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system. Brunk I, et al. FASEB J, 2008 Oct. PMID 18606864, Free PMC Article
  2. Role of the guanine nucleotide binding protein, Gα(o,) in the development of morphine tolerance and dependence. Lamberts JT, et al. Psychopharmacology (Berl), 2018 Jan. PMID 28971229, Free PMC Article
  3. Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o). Greif GJ, et al. J Neurophysiol, 2000 Feb. PMID 10669512
  4. Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice. Choi JM, et al. Proc Natl Acad Sci U S A, 2016 Sep 27. PMID 27625425, Free PMC Article
  5. The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. Ang R, et al. Physiol Rep, 2016 Aug. PMID 27528004, Free PMC Article

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AAV9-Mediated Intrastriatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice.
    Title: AAV9-Mediated Intrastriatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice.
  2. The Schwann cell-specific G-protein Galphao (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system.
    Title: The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system.
  3. The regulatory role of Gnao1 protein in diabetic encephalopathy in KK-Ay mice and streptozotocin-induced diabetic rats.
    Title: The regulatory role of Gnao1 protein in diabetic encephalopathy in KK-Ay mice and streptozotocin-induced diabetic rats.
  4. Mice with monoallelic GNAO1 loss exhibit reduced inhibitory synaptic input to cerebellar Purkinje cells.
    Title: Mice with monoallelic GNAO1 loss exhibit reduced inhibitory synaptic input to cerebellar Purkinje cells.
  5. Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation.
    Title: Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation.
  6. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca(2+) Homeostasis.
    Title: NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca(2+) Homeostasis.
  7. Mice Expressing Regulators of G protein Signaling-insensitive Galphao Define Roles of mu Opioid Receptor Galphao and Galphai Subunit Coupling in Inhibition of Presynaptic GABA Release.
    Title: Mice Expressing Regulators of G protein Signaling-insensitive Gαo Define Roles of μ Opioid Receptor Gαo and Gαi Subunit Coupling in Inhibition of Presynaptic GABA Release.
  8. Inhibitory signaling in mammalian olfactory transduction potentially mediated by Galphao.
    Title: Inhibitory signaling in mammalian olfactory transduction potentially mediated by Gα(o).
  9. GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.
    Title: GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.
  10. Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone.
    Title: Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled serotonin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables corticotropin-releasing hormone receptor 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables corticotropin-releasing hormone receptor 1 binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mu-type opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mu-type opioid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_negative_effect vesicle docking involved in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in myelin sheath HDA PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
  
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(o) subunit alpha
Names
GTP-binding protein alpha-o subunit
Go alpha
heterotrimeric guanine nucleotide-binding protein 1g

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113384.2 → NP_001106855.1  guanine nucleotide-binding protein G(o) subunit alpha isoform B

    See identical proteins and their annotated locations for NP_001106855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) includes alternate exons in the 3' coding region, compared to variant a, resulting in isoform b (also known as G0B-alpha) that has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC102398, AC138118
    Consensus CDS
    CCDS85585.1
    UniProtKB/Swiss-Prot
    P18872
    Related
    ENSMUSP00000148550.2, ENSMUST00000138659.9
    Conserved Domains (2) summary
    cd00066
    Location:34 → 348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:14 → 352
    G_alpha; G protein alpha subunit

  2. NM_001414907.1 → NP_001401836.1  guanine nucleotide-binding protein G(o) subunit alpha isoform A

    Status: VALIDATED

    Source sequence(s)
    AC102398, AC138118
    UniProtKB/Swiss-Prot
    P18872, P18873
    UniProtKB/TrEMBL
    Q543S2
    Related
    ENSMUSP00000114144.2, ENSMUST00000125716.8

  3. NM_001414908.1 → NP_001401837.1  guanine nucleotide-binding protein G(o) subunit alpha isoform C

    Status: VALIDATED

    Source sequence(s)
    AC102398, AC138118

  4. NM_010308.4 → NP_034438.1  guanine nucleotide-binding protein G(o) subunit alpha isoform A

    See identical proteins and their annotated locations for NP_034438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the shorter transcript and encodes isoform a, also known as G0A-alpha.
    Source sequence(s)
    AC102398, AC138118
    Consensus CDS
    CCDS22532.1
    UniProtKB/Swiss-Prot
    P18872, P18873
    UniProtKB/TrEMBL
    Q543S2
    Related
    ENSMUSP00000034198.9, ENSMUST00000034198.15
    Conserved Domains (1) summary
    cd00066
    Location:34 → 348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RNA

  1. NR_188943.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102398, AC138118

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94537213..94696016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18872.3 GenPept UniProtKB/Swiss-Prot:P18872

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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