Grik5 glutamate receptor, ionotropic, kainate 5 (gamma 2) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grik5provided by MGI
Official Full Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)provided by MGI
Primary source: MGI:MGI:95818
See related: Ensembl:ENSMUSG00000003378 AllianceGenome:MGI:95818
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KA2; GluK5; GluRgamma2
Summary: Enables kainate selective glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within excitatory postsynaptic potential; glutamatergic synaptic transmission; and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Located in endoplasmic reticulum and postsynaptic membrane. Part of kainate selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 48.9), whole brain E14.5 (RPKM 44.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.73 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24709274..24775421, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25009849..25075694, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that Grik5 gene expression in mouse dorsal raphe nucleus
Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Postsynaptic and presynaptic mossy-fiber kainate receptor function is altered in neurons from KA2-/- mice; presynaptic facilitatory autoreceptor had a reduced affinity for exogenous agonists and synaptic glutamate
Title: Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice.
Trafficking motifs in both intracellular loop and C terminus regulate KA2 surface expression; however, in neurons, GluR6 oligomerization is required for egress of KA2 from endoplasmic reticulum and transport to cell surface.
Title: Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2.
Association between COPI proteins and KA2 subunits was significantly reduced upon alanine substitution of this signal in the cytoplasmic tail of KA2.
Title: Intracellular trafficking of KA2 kainate receptors mediated by interactions with coatomer protein complex I (COPI) and 14-3-3 chaperone systems.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit192 (e-PCR), detects polymorphism
- UniSTS:131084

Grik5 (e-PCR), detects polymorphism
- UniSTS:496047

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kainate selective glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables kainate selective glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein retention in ER lumen	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ionotropic glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kainate selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor ionotropic, kainate 5

Names: gluR gamma-2; glutamate receptor KA-2; glutamate receptor gamma-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360067.2 → NP_001346996.1 glutamate receptor ionotropic, kainate 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC125468

UniProtKB/TrEMBL

Q2TAX1, Q80WU3

Conserved Domains (2) summary

cl10011
Location:1 → 208

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:223 → 593

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
NM_001402847.1 → NP_001389776.1 glutamate receptor ionotropic, kainate 5 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC125468

Conserved Domains (2) summary

cd06394
Location:23 → 401

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

cl21456
Location:414 → 785

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
NM_001402848.1 → NP_001389777.1 glutamate receptor ionotropic, kainate 5 isoform 4

Status: VALIDATED

Source sequence(s)

AC125468

Conserved Domains (2) summary

cl10011
Location:1 → 320

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:333 → 704

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
NM_001402849.1 → NP_001389778.1 glutamate receptor ionotropic, kainate 5 isoform 5

Status: VALIDATED

Source sequence(s)

AC125468
NM_008168.3 → NP_032194.2 glutamate receptor ionotropic, kainate 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_032194.2

Status: VALIDATED

Source sequence(s)

AC125468

Consensus CDS

CCDS20970.1

UniProtKB/Swiss-Prot

G5E822, Q61626

UniProtKB/TrEMBL

Q2TAX1, Q80WU3

Related

ENSMUSP00000003468.9, ENSMUST00000003468.10

Conserved Domains (2) summary

cd06394
Location:23 → 401

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

cl21456
Location:414 → 784

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

24709274..24775421 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152684.1 → XP_036008577.1 glutamate receptor ionotropic, kainate 5 isoform X2

UniProtKB/TrEMBL

Q2TAX1, Q80WU3

Conserved Domains (2) summary

cd06394
Location:23 → 424

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

cl21456
Location:437 → 808

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030242145.2 → XP_030098005.1 glutamate receptor ionotropic, kainate 5 isoform X6

UniProtKB/TrEMBL

Q2TAX1, Q80WU3

Conserved Domains (2) summary

cl10011
Location:1 → 320

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:333 → 703

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030242146.2 → XP_030098006.1 glutamate receptor ionotropic, kainate 5 isoform X8

Conserved Domains (2) summary

cl10011
Location:32 → 206

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:219 → 589

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030242143.2 → XP_030098003.1 glutamate receptor ionotropic, kainate 5 isoform X2

UniProtKB/TrEMBL

Q2TAX1, Q80WU3

Conserved Domains (2) summary

cd06394
Location:23 → 424

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

cl21456
Location:437 → 808

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030242149.2 → XP_030098009.1 glutamate receptor ionotropic, kainate 5 isoform X12

Conserved Domains (1) summary

cl21456
Location:16 → 386

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_006539552.5 → XP_006539615.1 glutamate receptor ionotropic, kainate 5 isoform X7

UniProtKB/TrEMBL

Q2TAX1, Q80WU3

Conserved Domains (2) summary

cl10011
Location:1 → 233

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:246 → 617

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030242142.1 → XP_030098002.1 glutamate receptor ionotropic, kainate 5 isoform X1

UniProtKB/TrEMBL

Q2TAX1, Q80WU3

Conserved Domains (2) summary

cd06394
Location:23 → 424

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

cl21456
Location:437 → 807

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_036152685.1 → XP_036008578.1 glutamate receptor ionotropic, kainate 5 isoform X4

UniProtKB/TrEMBL

Q2TAX1, Q80WU3

Conserved Domains (2) summary

cl10011
Location:1 → 343

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:356 → 727

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_036152686.1 → XP_036008579.1 glutamate receptor ionotropic, kainate 5 isoform X9

Conserved Domains (2) summary

cl10011
Location:1 → 167

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:180 → 551

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030242148.1 → XP_030098008.1 glutamate receptor ionotropic, kainate 5 isoform X11

Conserved Domains (2) summary

cd06394
Location:23 → 424

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

cl21456
Location:437 → 636

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily