Cxcl1 C-X-C motif chemokine ligand 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxcl1provided by MGI
Official Full Name: C-X-C motif chemokine ligand 1provided by MGI
Primary source: MGI:MGI:108068
See related: Ensembl:ENSMUSG00000029380 AllianceGenome:MGI:108068
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1
Summary: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
Expression: Broad expression in ovary adult (RPKM 2.9), placenta adult (RPKM 2.3) and 22 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 E1; 5 44.78 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (91039104..91040980)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (90891245..90893121)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCL1-CXCR2 axis mediates inflammatory response after sciatic nerve injury by regulating macrophage infiltration.
Title: CXCL1-CXCR2 axis mediates inflammatory response after sciatic nerve injury by regulating macrophage infiltration.
C-X-C Motif Chemokine Ligand 1 Promotes Colitis by Modulating the Gut Microbiota.
Title: C-X-C Motif Chemokine Ligand 1 Promotes Colitis by Modulating the Gut Microbiota.
Chemokine (C-X-C motif) ligand 1 maintains the immune surveillance function of natural killer cells via the PDK2/mTOR signaling pathway.
Title: Chemokine (C-X-C motif) ligand 1 maintains the immune surveillance function of natural killer cells via the PDK2/mTOR signaling pathway.
Knockdown of CXCL1 improves ACLF by reducing neutrophil recruitment to attenuate ROS production and hepatocyte apoptosis.
Title: Knockdown of CXCL1 improves ACLF by reducing neutrophil recruitment to attenuate ROS production and hepatocyte apoptosis.
Dysregulation of CXCL1 Expression and Neutrophil Recruitment in Insulin Resistance and Diabetes-Related Periodontitis in Male Mice.
Title: Dysregulation of CXCL1 Expression and Neutrophil Recruitment in Insulin Resistance and Diabetes-Related Periodontitis in Male Mice.
Transcriptomic Profiling Reveals Chemokine CXCL1 as a Mediator for Neutrophil Recruitment Associated With Blood-Retinal Barrier Alteration in Diabetic Retinopathy.
Title: Transcriptomic Profiling Reveals Chemokine CXCL1 as a Mediator for Neutrophil Recruitment Associated With Blood-Retinal Barrier Alteration in Diabetic Retinopathy.
Murine Placental Erythroid Cells Are Mainly Represented by CD45[+] Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines.
Title: Murine Placental Erythroid Cells Are Mainly Represented by CD45(+) Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines.
Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.
Title: Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.
CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut-brain axis.
Title: CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut-brain axis.
CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration.
Title: CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration.

Submit: New GeneRIF Correction See all GeneRIFs (143)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (1) 1 citation

General gene information

Go to the top of the page Help

Markers

PMC108388P1 (e-PCR)
- UniSTS:270136

PMC108388P2 (e-PCR)
- UniSTS:270137

Gro1 (e-PCR), detects polymorphism
- UniSTS:166220

Cxcl1 (e-PCR), detects polymorphism
- UniSTS:536444

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-17	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neutrophil mediated killing of fungus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: growth-regulated alpha protein

Names: C-X-C motif chemokine 1; GRO1 oncogene; KC/GR)-alpha; KC/GRO-alpha; alpha-chemokine; chemokine (C-X-C motif) ligand 1; platelet-derived growth factor-inducible protein KC; secretory protein N51

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008176.3 → NP_032202.1 growth-regulated alpha protein precursor

See identical proteins and their annotated locations for NP_032202.1

Status: REVIEWED

Source sequence(s)

BQ031102, BY335927

Consensus CDS

CCDS39143.1

UniProtKB/Swiss-Prot

P12850

UniProtKB/TrEMBL

A2RTH0, Q5U5W9

Related

ENSMUSP00000031327.9, ENSMUST00000031327.9

Conserved Domains (1) summary

cd00273
Location:30 → 92

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...