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Gsg1 germ cell associated 1 [ Mus musculus (house mouse) ]

Gene ID: 14840, updated on 27-Nov-2024

Summary

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Official Symbol
Gsg1provided by MGI
Official Full Name
germ cell associated 1provided by MGI
Primary source
MGI:MGI:1194499
See related
Ensembl:ENSMUSG00000030206 AllianceGenome:MGI:1194499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables RNA polymerase binding activity. Located in endoplasmic reticulum. Orthologous to human GSG1 (germ cell associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 1505.6) See more
Orthologs
human all
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Genomic context

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See Gsg1 in Genome Data Viewer
Location:
6 G1; 6 66.07 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135214327..135231334, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135237329..135254336, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19434 Neighboring gene predicted gene, 36533 Neighboring gene family with sequence similarity 234, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:135168385-135168675 Neighboring gene predicted gene, 57750 Neighboring gene STARR-seq mESC enhancer starr_17565 Neighboring gene predicted gene, 36640 Neighboring gene STARR-seq mESC enhancer starr_17566 Neighboring gene predicted gene, 36582 Neighboring gene phosphatidylethanolamine binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of cDNA clones specifically expressed in testicular germ cells. Tanaka H, et al. FEBS Lett, 1994 Nov 21. PMID 7957958
  2. Germ cell-specific gene 1 targets testis-specific poly(A) polymerase to the endoplasmic reticulum through protein-protein interactions. Choi HS, et al. FEBS Lett, 2008 Apr 9. PMID 18325338
  3. Mapping of six germ-cell-specific genes to mouse chromosomes. Matsui M, et al. Mamm Genome, 1997. PMID 9337410
  4. Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina. Park KU, et al. Invest Ophthalmol Vis Sci, 2017 Feb 1. PMID 28199486, Free PMC Article
  5. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression of GSG1 stimulates TPAP targeting to the ER, suggesting that interactions between the two proteins lead to the redistribution of TPAP from the cytosol to the ER
    Title: Germ cell-specific gene 1 targets testis-specific poly(A) polymerase to the endoplasmic reticulum through protein-protein interactions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
germ cell-specific gene 1 protein
Names
germ cell-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080552.1 → NP_001074021.1  germ cell-specific gene 1 protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC023009
    Consensus CDS
    CCDS39682.1
    UniProtKB/Swiss-Prot
    Q8C2N5, Q8R1W2, Q9D9Z3, Q9Z1H7
    Related
    ENSMUSP00000085022.6, ENSMUST00000087729.12
    Conserved Domains (1) summary
    pfam07803
    Location:13 → 125
    GSG-1; GSG1-like protein

  2. NM_001080553.1 → NP_001074022.1  germ cell-specific gene 1 protein isoform b

    See identical proteins and their annotated locations for NP_001074022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BC023009, BY098420
    Consensus CDS
    CCDS39683.1
    UniProtKB/TrEMBL
    E9QQ16
    Related
    ENSMUSP00000107541.2, ENSMUST00000111910.4
    Conserved Domains (1) summary
    pfam07803
    Location:10 → 122
    GSG-1; GSG1-like protein

  3. NM_010352.2 → NP_034482.2  germ cell-specific gene 1 protein isoform b

    See identical proteins and their annotated locations for NP_034482.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BC023009, BY098420, CA465575
    Consensus CDS
    CCDS39683.1
    UniProtKB/TrEMBL
    E9QQ16
    Related
    ENSMUSP00000107542.3, ENSMUST00000111911.9
    Conserved Domains (1) summary
    pfam07803
    Location:10 → 122
    GSG-1; GSG1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    135214327..135231334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1W2.2 GenPept UniProtKB/Swiss-Prot:Q8R1W2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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