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Cfap20 cilia and flagella associated protein 20 [ Mus musculus (house mouse) ]

Gene ID: 14894, updated on 27-Nov-2024

Summary

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Official Symbol
Cfap20provided by MGI
Official Full Name
cilia and flagella associated protein 20provided by MGI
Primary source
MGI:MGI:107428
See related
Ensembl:ENSMUSG00000031796 AllianceGenome:MGI:107428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtl3; T10-2A2; 2600014O15Rik
Summary
Involved in flagellated sperm motility. Located in cilium. Is active in axonemal B tubule inner sheath and sperm flagellum. Is expressed in several structures, including alimentary system; blastocyst; hemolymphoid system gland; olfactory epithelium; and retina nuclear layer. Orthologous to human CFAP20 (cilia and flagella associated protein 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 41.9), testis adult (RPKM 40.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cfap20 in Genome Data Viewer
Location:
8 C5; 8 47.12 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96146867..96161716, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95420249..95434869, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8259 Neighboring gene zinc finger protein 319 Neighboring gene U6 snRNA biogenesis 1 Neighboring gene matrix metallopeptidase 15 Neighboring gene VISTA enhancer mm71 Neighboring gene STARR-positive B cell enhancer ABC_E245 Neighboring gene casein kinase 2, alpha prime polypeptide Neighboring gene STARR-seq mESC enhancer starr_22388 Neighboring gene RIKEN cDNA 4933406B17 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rapid mapping of genomic P1 clones: the mouse L-isoaspartyl/D-aspartyl methyltransferase gene. MacLaren DC, et al. Genomics, 1996 Jul 15. PMID 8661142
  2. Sequence and expression pattern of an evolutionarily conserved transcript identified by gene trapping. Rijkers T, et al. Biochim Biophys Acta, 1996 Jul 17. PMID 8688464
  3. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article
  4. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
  5. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyglutamylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cilium beat frequency involved in ciliary motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cilium beat frequency involved in ciliary motility ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium beat frequency involved in ciliary motility ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axonemal B tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cilia- and flagella-associated protein 20
Names
UPF0468 protein C16orf80 homolog
gene trap locus 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008187.2 → NP_032213.2  cilia- and flagella-associated protein 20

    See identical proteins and their annotated locations for NP_032213.2

    Status: VALIDATED

    Source sequence(s)
    BC119023, BM934726, CB195345
    Consensus CDS
    CCDS40445.1
    UniProtKB/Swiss-Prot
    P70212, Q3T9D6, Q8BTU1
    Related
    ENSMUSP00000034249.7, ENSMUST00000034249.8
    Conserved Domains (1) summary
    pfam05018
    Location:1 → 185
    DUF667; Protein of unknown function (DUF667)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    96146867..96161716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153763.1 → XP_036009656.1  cilia- and flagella-associated protein 20 isoform X2

    UniProtKB/Swiss-Prot
    P70212, Q3T9D6, Q8BTU1
    Conserved Domains (1) summary
    pfam05018
    Location:1 → 185
    DUF667; Protein of unknown function (DUF667)

  2. XM_036153762.1 → XP_036009655.1  cilia- and flagella-associated protein 20 isoform X1

    Conserved Domains (1) summary
    pfam05018
    Location:142 → 272
    DUF667; Protein of unknown function (DUF667)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTU1.1 GenPept UniProtKB/Swiss-Prot:Q8BTU1

Gene LinkOut

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