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M membrane glycoprotein M [ SARS coronavirus Tor2 ]

Gene ID: 1489672, updated on 6-Jun-2024

Summary

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Gene symbol
M
Gene description
membrane glycoprotein M
Locus tag
sars5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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Genomic context

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Sequence:
NC_004718.3 (26398..27063)

NC_004718.3Genomic Context describing neighboring genes Neighboring gene ORF3a protein Neighboring gene ORF3b protein Neighboring gene small envelope protein Neighboring gene ORF6 protein Neighboring gene ORF7a protein Neighboring gene ORF7b protein Neighboring gene ORF8a protein Neighboring gene ORF8b protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004718.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein. Lai CW, et al. FEBS Lett, 2006 Jul 10. PMID 16797548, Free PMC Article
  2. Characterization of protein-protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus. He R, et al. Virus Res, 2004 Oct. PMID 15351485, Free PMC Article
  3. Subcellular localization and membrane association of SARS-CoV 3a protein. Yuan X, et al. Virus Res, 2005 May. PMID 15763150, Free PMC Article
  4. Peptide domain involved in the interaction between membrane protein and nucleocapsid protein of SARS-associated coronavirus. Fang X, et al. J Biochem Mol Biol, 2005 Jul 31. PMID 16053703
  5. Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction. Luo H, et al. Int J Biochem Cell Biol, 2006. PMID 16343974, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific amino acids are critical for M protein function in terms of directing virus assembly.
    Title: Identifying SARS-CoV membrane protein amino acid residues linked to virus-like particle assembly.
  2. When Y(195) was mutated to alanine, M(Y195A) no longer retained S intracellularly at the Golgi. Y(195) is necessary for efficient SARS-CoV S-M interaction and, thus, has a significant involvement in assembly of infectious virus.
    Title: A single tyrosine in the severe acute respiratory syndrome coronavirus membrane protein cytoplasmic tail is important for efficient interaction with spike protein.
  3. Both the transmembrane domains of E protein are required to interact with M protein, while either of the hydrophilic regions (a.a. 1-10 or 60-76) is dispensable as shown by co-immunoprecipitation assay.
    Title: Expression and membrane integration of SARS-CoV E protein and its interaction with M protein.
  4. the expression of M protein prevents the formation of TRAF3.TANK.TBK1/IKKepsilon complex and thereby inhibits TBK1/IKKepsilon-dependent activation of IRF3/IRF7 transcription factors
    Title: Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.
  5. cytoplasmic C-terminus domain of SARS-CoV M protein was responsible for binding to NC protein
    Title: Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus.
  6. both E and N proteins must be coexpressed with M protein for the efficient production and release of virus-like particles by transfected Vero E6 cells.
    Title: The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles.
  7. Like S, M acquires high-mannose N-glycans that are subsequently modified into complex N-glycans in the Golgi.
    Title: Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E.
  8. The crystal structure of M(pro) at a resolution of 1.82 Angstroms, in space group P2(1) at pH 6.0, is reported.
    Title: Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase.
  9. This is the first report describing the induction of apoptosis by SARS-CoV M protein in animal cells and possible implications are discussed.
    Title: Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein.
  10. The results show that M and N proteins of SARS-CoV can induce apoptosis of human pulmonary fibroblast cells.
    Title: M and N proteins of SARS coronavirus induce apoptosis in HPF cells.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
membrane glycoprotein M

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004718.3 Reference assembly

    Range
    26398..27063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009825055.1 membrane glycoprotein M [SARS coronavirus Tor2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P59596, Q6S8E5, Q7T6Q8, Q7T6R1, Q7T6R5, Q7T6S0, Q7T6S3, Q7T726, Q7T7P6, Q7T7S6, Q7TA12
    UniProtKB/TrEMBL
    A0A2D1PX06, A0A2D1PX75, A0A3G5BIZ3, A7J8L8, B8Q8T0, B8Q8U1, C4P6R1, D2E1D6, D2E1F1, D3KDM9, J9T583, J9TEG5, Q1EFM8, Q1EFP1, Q3S2C1, Q3ZTC1, Q3ZTD6, Q3ZTE9, Q4JDQ0, Q4JDR3, Q5DIC1, Q5Y183, Q66VB9, Q692E0, Q6GYQ7, Q6QJ38, Q6R7Y2, Q6RCW1, Q6RCZ4, Q6RD16, Q6RD27, Q6RD38, Q6S8D3, Q6T1D8, Q6TPE4, Q6V584
    Conserved Domains (1) summary
    cd21569
    Location:4 → 221
    SARS-like-CoV_M; Membrane (or Matrix) protein from Severe acute respiratory syndrome (SARS) coronavirus, SARS-CoV-2, and related betacoronaviruses in the B lineage
Nucleotide Protein
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