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ADIG adipogenin [ Homo sapiens (human) ]

Gene ID: 149685, updated on 27-Nov-2024

Summary

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Official Symbol
ADIGprovided by HGNC
Official Full Name
adipogeninprovided by HGNC
Primary source
HGNC:HGNC:28606
See related
Ensembl:ENSG00000182035 MIM:611396; AllianceGenome:HGNC:28606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMAF1
Summary
ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008]
Expression
Restricted expression toward testis (RPKM 13.2) See more
Orthologs
mouse all
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Genomic context

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See ADIG in Genome Data Viewer
Location:
20q11.23
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (38581197..38588463)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (40310849..40318109)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37209840..37217106)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein non-catalytic subunit beta Neighboring gene microRNA 548o-2 Neighboring gene ribosomal protein S3 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37189333-37189849 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:37193517-37194017 Neighboring gene MPRA-validated peak4208 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:37229033-37229574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:37236926-37237426 Neighboring gene Rho GTPase activating protein 40 Neighboring gene GINS complex subunit 2 (Psf2 homolog) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12900 Neighboring gene GATA motif-containing MPRA enhancer 112/113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12901 Neighboring gene MPRA-validated peak4211 silencer Neighboring gene VISTA enhancer hs2620 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:37342659-37343160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37354984-37355521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37355736-37356396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37357057-37357716 Neighboring gene solute carrier family 32 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. Hong YH, et al. Mol Cell Biochem, 2005 Aug. PMID 16132694
  2. Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesis. Kim JY, et al. Biochem Biophys Res Commun, 2005 Jan 7. PMID 15567149
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies in mouse indicate the 80 aa SMAF1 protein is involved in adipocyte tissue function or regulation.
    Title: Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Clone Names

  • KIAA1219, MGC39724, MGC149650

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in brown fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in white fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
adipogenin
Names
adipogenesis associated
small adipocyte factor 1 (SMAF1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393816.1 → NP_001380745.1  adipogenin isoform a

    Status: VALIDATED

    Source sequence(s)
    AL035419
    Consensus CDS
    CCDS54461.1
    UniProtKB/Swiss-Prot
    Q0VDE8
    UniProtKB/TrEMBL
    A0A158RFT8
    Related
    ENSP00000440331.2, ENST00000537425.3
    Conserved Domains (1) summary
    pfam15202
    Location:1 → 78
    Adipogenin

  2. NM_001393817.1 → NP_001380746.1  adipogenin isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (b).
    Source sequence(s)
    AL035419
    Consensus CDS
    CCDS93039.1
    UniProtKB/TrEMBL
    H0Y829
    Related
    ENSP00000416834.2, ENST00000416116.2
    Conserved Domains (1) summary
    pfam15202
    Location:1 → 78
    Adipogenin

RNA

  1. NR_172017.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035419

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    38581197..38588463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    40310849..40318109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_174906.3: Suppressed sequence

    Description
    NM_174906.3: This RefSeq was permanently suppressed because it contains the wrong CDS.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VDE8.1 GenPept UniProtKB/Swiss-Prot:Q0VDE8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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