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H2-T10 histocompatibility 2, T region locus 10 [ Mus musculus (house mouse) ]

Gene ID: 15024, updated on 27-Nov-2024

Summary

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Official Symbol
H2-T10provided by MGI
Official Full Name
histocompatibility 2, T region locus 10provided by MGI
Primary source
MGI:MGI:95942
See related
Ensembl:ENSMUSG00000079491 AllianceGenome:MGI:95942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2T10
Summary
Predicted to enable several functions, including beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Acts upstream of or within inner ear development. Predicted to be located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; lung; and musculoskeletal system. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to human HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Broad expression in thymus adult (RPKM 27.5), spleen adult (RPKM 12.0) and 15 other tissues See more
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Genomic context

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See H2-T10 in Genome Data Viewer
Location:
17 B1; 17 18.93 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36426763..36432336, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36115871..36121444, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42486 Neighboring gene predicted gene, 54002 Neighboring gene histocompatibility 2, T region locus, pseudogene Neighboring gene ribosomal protein S6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10950 Neighboring gene STARR-positive B cell enhancer ABC_E169 Neighboring gene histocompatibility-2, T region locus 25 Neighboring gene histocompatibility 2, T region pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The nature of major histocompatibility complex recognition by gamma delta T cells. Schild H, et al. Cell, 1994 Jan 14. PMID 8287478
  2. A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule. Crowley MP, et al. Science, 2000 Jan 14. PMID 10634788
  3. Role of a selecting ligand in shaping the murine γδ-TCR repertoire. Fahl SP, et al. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432160, Free PMC Article
  4. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Ito K, et al. Cell, 1990 Aug 10. PMID 2379238
  5. Functions of nonclassical MHC and non-MHC-encoded class I molecules. Braud VM, et al. Curr Opin Immunol, 1999 Feb. PMID 10047540

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
  
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histocompatibility 2, T region locus 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010395.7 → NP_034525.4  histocompatibility 2, T region locus 10 precursor

    See identical proteins and their annotated locations for NP_034525.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the coding allele found in NOD, 129, FVB/N, and other strains (PMID:2379238).
    Source sequence(s)
    AK088241, AK153876
    UniProtKB/TrEMBL
    Q861Q6, Q8WLM9
    Conserved Domains (2) summary
    cd07698
    Location:193 → 285
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:27 → 189
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RNA

  1. NR_046286.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the non-coding allele found in C57BL/6 (PMID:2379238).
    Source sequence(s)
    CT030728
    Related
    ENSMUST00000174625.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36426763..36432336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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