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H2-T18 histocompatibility 2, T region locus 18 [ Mus musculus (house mouse) ]

Gene ID: 15033, updated on 4-Jan-2025

Summary

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Official Symbol
H2-T18provided by MGI
Official Full Name
histocompatibility 2, T region locus 18provided by MGI
Primary source
MGI:MGI:95950
See related
AllianceGenome:MGI:95950
Gene type
protein coding
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tla; TLAg; H-2T18; MumuTL
Summary
Enables identical protein binding activity. [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
not in current annotation release
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Genomic context

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See H2-T18 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
108.20200622 latest, but not current GRCm38.p6 (GCF_000001635.26) 17 Unlocalized Scaffold (NOD/ShiLtJ) NT_187004.1 (2421903..2425482, complement)
108.20200622 latest, but not current GRCm38.p6 (GCF_000001635.26) 17 Unlocalized Scaffold (NOD/MrkTac) NT_187027.1 (2397290..2401913, complement)

Bibliography

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Related articles in PubMed

  1. Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen. Weber DA, et al. J Immunol, 2002 Nov 15. PMID 12421950
  2. Additional products of the Tla locus of the mouse. Chorney MJ, et al. Proc Natl Acad Sci U S A, 1985 Oct. PMID 3876563, Free PMC Article
  3. GENETIC DETERMINATION OF THE TL (THYMUSLEUKAEMIA) ANTIGEN IN THE MOUSE. BOYSE EA, et al. Nature, 1964 Feb 22. PMID 14161199
  4. Genomic organization of the mouse Tla locus: study of an endogenous retroviruslike locus reveals polymorphisms related to different Tla haplotypes. Pampeno C, et al. Immunogenetics, 1988. PMID 2901400
  5. A comment on the genetic data relating to expression of TL antigens. Boyse EA, et al. Transplantation, 1971 Jun. PMID 5579353

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The nonclassical class I molecule TL (T18d) spontaneously folds in vitro in the absence of peptides or other potential ligands and demonstrates by far UV-circular dichroism studies that it has structural features similar to classical class I molecules.
    Title: Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen.
  2. The extracellular domains of 27 new TL sequences from 10 species of Mus have been characterized that show hyperconservation of the putative antigen recognition site, based on the ratio of nonsynonymous and synonymous substitution.
    Title: Hyperconservation of the putative antigen recognition site of the MHC class I-b molecule TL in the subfamily Murinae: evidence that thymus leukemia antigen is an ancient mammalian gene.
  3. The stronger affinity of the TL Ag for CD8alphaalpha is largely mediated by three amino acids on exposed loops of the conserved alpha3 domain.
    Title: Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
histocompatibility 2, T region locus 18
Names
MHC class I antigen
TL Ag
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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