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H2-T22 histocompatibility 2, T region locus 22 [ Mus musculus (house mouse) ]

Gene ID: 15039, updated on 27-Nov-2024

Summary

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Official Symbol
H2-T22provided by MGI
Official Full Name
histocompatibility 2, T region locus 22provided by MGI
Primary source
MGI:MGI:95956
See related
Ensembl:ENSMUSG00000056116 AllianceGenome:MGI:95956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
27b; T22b; H-2T9; H2-T9; H-2T17; H-2T22; H2-T17
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver adult (RPKM 85.3), subcutaneous fat pad adult (RPKM 74.4) and 22 other tissues See more
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Genomic context

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See H2-T22 in Genome Data Viewer
Location:
17 B1; 17 18.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36348023..36353635, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36037128..36042742, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930015D03 gene Neighboring gene histocompatibility 2, T region locus 24 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36157683-36157870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36160698-36160881 Neighboring gene STARR-positive B cell enhancer ABC_E8675 Neighboring gene histocompatibility 2, T region locus 23 Neighboring gene STARR-positive B cell enhancer ABC_E168 Neighboring gene predicted gene 6034 Neighboring gene predicted gene, 54001 Neighboring gene histocompatibility 2, D region locus 1 pseudogene Neighboring gene histocompatibility 2, T region locus 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antigen-presenting cells for naive transgenic gamma delta T cells. Potent activation by activated alpha beta T cells. Spaner D, et al. J Immunol, 1995 Oct 15. PMID 7561093
  2. Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain. Liu J, et al. Neurochem Res, 2015 Jul. PMID 26040564
  3. Role of a selecting ligand in shaping the murine γδ-TCR repertoire. Fahl SP, et al. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432160, Free PMC Article
  4. Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Adams EJ, et al. Science, 2005 Apr 8. PMID 15821084
  5. A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types. Transy C, et al. J Exp Med, 1987 Aug 1. PMID 3036997, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC49483

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histocompatibility 2, T region locus 22
Names
MHC classIb T22
histocompatibility 2, T region locus 17
histocompatibility 2, T region locus 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347382.2 → NP_001334311.1  histocompatibility 2, T region locus 22 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112970
    Consensus CDS
    CCDS84308.1
    UniProtKB/TrEMBL
    A7VMS4, Q9BCZ1
    Related
    ENSMUSP00000056041.8, ENSMUST00000058801.15
    Conserved Domains (2) summary
    cd07698
    Location:195 → 286
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:29 → 191
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. NM_001359754.2 → NP_001346683.1  histocompatibility 2, T region locus 22 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC112970
    UniProtKB/TrEMBL
    A7VMS4
    Conserved Domains (2) summary
    cd07698
    Location:137 → 229
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:2 → 133
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  3. NM_001359755.2 → NP_001346684.1  histocompatibility 2, T region locus 22 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112970
    Consensus CDS
    CCDS37608.1
    UniProtKB/TrEMBL
    A7VMS4, Q31615
    Related
    ENSMUSP00000077111.7, ENSMUST00000077960.7
    Conserved Domains (2) summary
    cd07698
    Location:195 → 287
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:29 → 191
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  4. NM_001359756.2 → NP_001346685.1  histocompatibility 2, T region locus 22 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112970
    Consensus CDS
    CCDS84308.1
    UniProtKB/TrEMBL
    A7VMS4, Q9BCZ1
    Related
    ENSMUST00000172633.8
    Conserved Domains (2) summary
    cd07698
    Location:195 → 286
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:29 → 191
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  5. NM_010397.6 → NP_034527.1  histocompatibility 2, T region locus 22 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034527.1

    Status: VALIDATED

    Source sequence(s)
    AC112970
    Consensus CDS
    CCDS37608.1
    UniProtKB/TrEMBL
    A7VMS4, Q31615
    Related
    ENSMUSP00000078927.6, ENSMUST00000080015.12
    Conserved Domains (2) summary
    cd07698
    Location:195 → 287
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:29 → 191
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36348023..36353635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010396.2: Suppressed sequence

    Description
    NM_010396.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein Strain
Heading Accession and Version

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