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ADRA2B adrenoceptor alpha 2B [ Homo sapiens (human) ]

Gene ID: 151, updated on 27-Nov-2024

Summary

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Official Symbol
ADRA2Bprovided by HGNC
Official Full Name
adrenoceptor alpha 2Bprovided by HGNC
Primary source
HGNC:HGNC:282
See related
Ensembl:ENSG00000274286 MIM:104260; AllianceGenome:HGNC:282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR
Summary
This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
Orthologs
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Genomic context

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See ADRA2B in Genome Data Viewer
Location:
2q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (96112876..96116571, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (96619491..96623187, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96778624..96782310, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 2C, pseudogene Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial Neighboring gene uncharacterized LOC105373494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96725007-96725917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96757989-96758504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96774519-96775506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11747 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96798301-96798801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96800355-96800854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16189 Neighboring gene astacin like metalloendopeptidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96810561-96811062 Neighboring gene dual specificity phosphatase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study. Siitonen N, et al. Diabetologia, 2004 Aug. PMID 15309292
  2. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. King D, et al. Clin Pharmacol Ther, 2005 May. PMID 15900285
  3. Alpha2B-adrenergic receptor insertion/deletion polymorphism in women with spontaneous recurrent abortions. Galazios G, et al. J Obstet Gynaecol Res, 2011 Feb. PMID 21159032
  4. Genetic variation of the α2b-adrenoceptor affects neural correlates of successful emotional memory formation. Urner M, et al. Hum Brain Mapp, 2011 Dec. PMID 21259387, Free PMC Article
  5. Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. Muszkat M, et al. Pharmacogenet Genomics, 2005 Jun. PMID 15900214

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Beta2 ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA.
    Title: ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Β2 ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA.
  2. ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.
    Title: ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.
  3. Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region.
    Title: Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region.
  4. Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
    Title: Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
  5. Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory.
    Title: Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory.
  6. In the group of shors with arterial hypertension, high albuminuria was associated with polymorphisms of the ACE genes (OR=2.05), ADRA2B (OR=6.00),-- The primary predictors determining the development of high albuminuria among patients with arterial hypertension in both ethnic groups were genetic ones.
    Title: Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya.
  7. this meta-analysis has established the contributions of ADRA2B to the interactions between emotion and cognition, adding to the growing literature on individual differences in attention, perception and memory.
    Title: ADRA2B deletion variant and enhanced cognitive processing of emotional information: A meta-analytical review.
  8. Study show an associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population
    Title: Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.
  9. An exaggerated vasoconstriction response to dexmedetomidine, an alpha-2 adrenergic agonist, has been associated with deletion in the alpha-2B adrenoreceptor gene (ADRA2B deletion).
    Title: Lack of Association Between Adrenoreceptor Genotype and the Vasoconstriction Response to Dexmedetomidine.
  10. Data indicate an association of arterial stiffness and platelet alpha2B-Rs gene expression.
    Title: Increased platelet alpha(2B)-adrenergic receptor gene expression in well-controlled hypertensives: the effect of arterial stiffness.
Submit: New GeneRIF Correction See all GeneRIFs (93)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epinephrine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epinephrine secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of norepinephrine secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of norepinephrine secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor transactivation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of vascular associated smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
alpha-2B adrenergic receptor
Names
ADRA2B adrenergic, alpha-2B-, receptor
G-protein coupled receptor
alpha-2 adrenergic receptor subtype C2
alpha-2-adrenergic receptor-like 1
alpha-2B adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032950.1 RefSeqGene

    Range
    4579..8274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000682.7 → NP_000673.2  alpha-2B adrenergic receptor

    See identical proteins and their annotated locations for NP_000673.2

    Status: REVIEWED

    Source sequence(s)
    AC092603, BC133021
    Consensus CDS
    CCDS56129.1
    UniProtKB/Swiss-Prot
    A2RUS0, P18089, Q4TUH9, Q53RF2, Q9BZK0
    Related
    ENSP00000480573.1, ENST00000620793.2
    Conserved Domains (1) summary
    cd15321
    Location:7 → 437
    7tmA_alpha2B_AR; alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    96112876..96116571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    96619491..96623187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18089.4 GenPept UniProtKB/Swiss-Prot:P18089

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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