Hdgfl2 HDGF like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdgfl2provided by MGI
Official Full Name: HDGF like 2provided by MGI
Primary source: MGI:MGI:1194492
See related: Ensembl:ENSMUSG00000002833 AllianceGenome:MGI:1194492
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HRP-2; Hdgfrp2
Summary: Predicted to enable H3K27me3 modified histone binding activity and H3K9me3 modified histone binding activity. Involved in muscle cell differentiation and skeletal muscle tissue regeneration. Located in nucleus. Is expressed in brain; dorsal root ganglion; intestine; and retina. Orthologous to human HDGFL2 (HDGF like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 36.8), testis adult (RPKM 27.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 29.15 cM; 17 D

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56386661..56407605)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56079599..56100605)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.
Title: Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.
HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.
Title: HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.
The role of HRP2 protein in cardiac development
Title: Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.
HRP-2 can promote hepatocellular carcinoma cells growth in vitro and xenograft tumors in vivo.
Title: HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma.
The results show that HRP2 plays a role in HIV-1 integration when LEDGF/p75 is absent.
Title: HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables H3K27me3 modified histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables H3K27me3 modified histone binding	ISO Inferred from Sequence Orthology more info
enables H3K27me3 modified histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables H3K9me3 modified histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables H3K9me3 modified histone binding	ISO Inferred from Sequence Orthology more info
enables H3K9me3 modified histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone reader activity	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair-dependent chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hepatoma-derived growth factor-related protein 2

Names: hepatoma-derived growth factor, related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304784.3 → NP_001291713.1 hepatoma-derived growth factor-related protein 2 isoform 1

See identical proteins and their annotated locations for NP_001291713.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

CT009719

Consensus CDS

CCDS89122.1

UniProtKB/Swiss-Prot

Q3UMU9

Related

ENSMUSP00000153249.2, ENSMUST00000225843.2

Conserved Domains (2) summary

cd05834
Location:3 → 87

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

pfam11467
Location:477 → 561

LEDGF; Lens epithelium-derived growth factor (LEDGF)
NM_001304785.3 → NP_001291714.1 hepatoma-derived growth factor-related protein 2 isoform 3

See identical proteins and their annotated locations for NP_001291714.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses alternate in-frame splice sites in an internal exon and the 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

CT009719

Consensus CDS

CCDS89123.1

UniProtKB/Swiss-Prot

Q3UMU9

Related

ENSMUSP00000002911.10, ENSMUST00000002911.10

Conserved Domains (2) summary

cd05834
Location:3 → 87

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

pfam11467
Location:467 → 551

LEDGF; Lens epithelium-derived growth factor (LEDGF)
NM_001331053.2 → NP_001317982.1 hepatoma-derived growth factor-related protein 2 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 4, which is one amino acid shorter than isoform 1.

Source sequence(s)

CT009719

UniProtKB/Swiss-Prot

Q3UMU9

Conserved Domains (2) summary

cd05834
Location:3 → 87

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

pfam11467
Location:477 → 561

LEDGF; Lens epithelium-derived growth factor (LEDGF)
NM_001424790.1 → NP_001411719.1 hepatoma-derived growth factor-related protein 2 isoform 5

Status: VALIDATED

Source sequence(s)

CT009719
NM_008233.5 → NP_032259.1 hepatoma-derived growth factor-related protein 2 isoform 2

See identical proteins and their annotated locations for NP_032259.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

CT009719

Consensus CDS

CCDS28894.1

UniProtKB/Swiss-Prot

D6CHX5, O35540, Q3UIH6, Q3UMU9, Q99L92

Related

ENSMUSP00000152948.2, ENSMUST00000226053.2

Conserved Domains (2) summary

cd05834
Location:3 → 87

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

pfam11467
Location:468 → 552

LEDGF; Lens epithelium-derived growth factor (LEDGF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

56386661..56407605

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249512.2 → XP_030105372.1 hepatoma-derived growth factor-related protein 2 isoform X3

Conserved Domains (1) summary

pfam11467
Location:352 → 437

LEDGF; Lens epithelium-derived growth factor (LEDGF)
XM_030249513.2 → XP_030105373.1 hepatoma-derived growth factor-related protein 2 isoform X5

Conserved Domains (1) summary

pfam11467
Location:343 → 428

LEDGF; Lens epithelium-derived growth factor (LEDGF)
XM_006523708.4 → XP_006523771.1 hepatoma-derived growth factor-related protein 2 isoform X2

Conserved Domains (1) summary

pfam11467
Location:352 → 437

LEDGF; Lens epithelium-derived growth factor (LEDGF)
XM_006523709.4 → XP_006523772.1 hepatoma-derived growth factor-related protein 2 isoform X4

See identical proteins and their annotated locations for XP_006523772.1

Conserved Domains (1) summary

pfam11467
Location:343 → 428

LEDGF; Lens epithelium-derived growth factor (LEDGF)