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Hes3 hes family bHLH transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 15207, updated on 27-Nov-2024

Summary

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Official Symbol
Hes3provided by MGI
Official Full Name
hes family bHLH transcription factor 3provided by MGI
Primary source
MGI:MGI:104877
See related
Ensembl:ENSMUSG00000028946 AllianceGenome:MGI:104877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hes-3; bHLHb43
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and regulation of timing of neuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 9.7) and CNS E11.5 (RPKM 0.6) See more
Orthologs
human all
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Genomic context

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See Hes3 in Genome Data Viewer
Location:
4 E2; 4 83.01 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152369707..152376133, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152285250..152291911, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12198 Neighboring gene predicted gene, 30622 Neighboring gene STARR-positive B cell enhancer ABC_E6292 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene STARR-seq mESC enhancer starr_12200 Neighboring gene STARR-positive B cell enhancer ABC_E9627 Neighboring gene G protein-coupled receptor 153 Neighboring gene STARR-positive B cell enhancer ABC_E4736 Neighboring gene STARR-positive B cell enhancer ABC_E3558 Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene ring finger protein 207 Neighboring gene ribosomal protein L22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain. Nikolakopoulou P, et al. Sci Rep, 2018 Jul 27. PMID 30054579, Free PMC Article
  2. Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination. Toutouna L, et al. Brain Res, 2016 Jul 1. PMID 27018293
  3. Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons. Hirata H, et al. J Biol Chem, 2000 Jun 23. PMID 10858455
  4. Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma. Sharma S, et al. Cancer Res, 2001 Sep 1. PMID 11522634
  5. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. Economopoulou M, et al. Int J Radiat Biol, 2014 Aug. PMID 24512568

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hes3 expression is reduced at peak demyelination and is partially restored within 1 week after cuprizone withdrawal. This raises the possibility of Hes3 involvement in demyelination/remyelination.
    Title: Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination.
  2. expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium
    Title: Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium.
  3. Mamld1 enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3-related non-canonical Notch signaling
    Title: Mamld1 knockdown reduces testosterone production and Cyp17a1 expression in mouse Leydig tumor cells.
  4. CXorf6 transactivates the Hes3 promoter, augments testosterone production
    Title: Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.
  5. inactivation of Hes1 and Hes5, known Notch effectors, and additional inactivation of Hes3 extensively accelerate cell differentiation and cause a wide range of defects in brain formation
    Title: Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC144657

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hindbrain morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural tube development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within oculomotor nerve development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of neurogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of timing of neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within trochlear nerve development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor HES-3
Names
hairy and enhancer of split 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403791.1 → NP_001390720.1  transcription factor HES-3

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/Swiss-Prot
    O09083, O09150, Q61657, Q8BTI2

  2. NM_001403792.1 → NP_001390721.1  transcription factor HES-3

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/Swiss-Prot
    O09083, O09150, Q61657, Q8BTI2

  3. NM_001403793.1 → NP_001390722.1  transcription factor HES-3

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/Swiss-Prot
    O09083, O09150, Q61657, Q8BTI2

  4. NM_001403794.1 → NP_001390723.1  transcription factor HES-3

    Status: VALIDATED

    Source sequence(s)
    AL611985
    UniProtKB/Swiss-Prot
    O09083, O09150, Q61657, Q8BTI2

  5. NM_008237.5 → NP_032263.2  transcription factor HES-3

    See identical proteins and their annotated locations for NP_032263.2

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS18997.1
    UniProtKB/Swiss-Prot
    O09083, O09150, Q61657, Q8BTI2
    UniProtKB/TrEMBL
    Q9JHC5
    Related
    ENSMUSP00000092006.2, ENSMUST00000094438.2
    Conserved Domains (1) summary
    cd18933
    Location:1 → 55
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152369707..152376133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250192.4 → XP_011248494.1  transcription factor HES-3 isoform X3

    See identical proteins and their annotated locations for XP_011248494.1

    UniProtKB/TrEMBL
    A0A1W2P7Y8, Q9JHC5
    Conserved Domains (1) summary
    cd18933
    Location:26 → 80
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

  2. XM_011250190.4 → XP_011248492.1  transcription factor HES-3 isoform X3

    See identical proteins and their annotated locations for XP_011248492.1

    UniProtKB/TrEMBL
    A0A1W2P7Y8, Q9JHC5
    Conserved Domains (1) summary
    cd18933
    Location:26 → 80
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

  3. XM_011250191.4 → XP_011248493.1  transcription factor HES-3 isoform X3

    See identical proteins and their annotated locations for XP_011248493.1

    UniProtKB/TrEMBL
    A0A1W2P7Y8, Q9JHC5
    Conserved Domains (1) summary
    cd18933
    Location:26 → 80
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

  4. XM_036163689.1 → XP_036019582.1  transcription factor HES-3 isoform X3

    UniProtKB/TrEMBL
    A0A1W2P7Y8, Q9JHC5
    Conserved Domains (1) summary
    cd18933
    Location:26 → 80
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

  5. XM_011250189.3 → XP_011248491.1  transcription factor HES-3 isoform X1

    Conserved Domains (1) summary
    cd18933
    Location:117 → 171
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

  6. XM_011250194.4 → XP_011248496.1  transcription factor HES-3 isoform X5

    See identical proteins and their annotated locations for XP_011248496.1

    UniProtKB/TrEMBL
    Q9JHC5
    Conserved Domains (1) summary
    cd18933
    Location:8 → 62
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

  7. XM_036163690.1 → XP_036019583.1  transcription factor HES-3 isoform X3

    UniProtKB/TrEMBL
    A0A1W2P7Y8, Q9JHC5
    Related
    ENSMUSP00000151815.2, ENSMUST00000218045.2
    Conserved Domains (1) summary
    cd18933
    Location:26 → 80
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

  8. XM_030253216.1 → XP_030109076.1  transcription factor HES-3 isoform X4

    UniProtKB/Swiss-Prot
    O09083, O09150, Q61657, Q8BTI2
    UniProtKB/TrEMBL
    Q9JHC5
    Conserved Domains (1) summary
    cd18933
    Location:1 → 55
    bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61657.2 GenPept UniProtKB/Swiss-Prot:Q61657

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