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Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 [ Mus musculus (house mouse) ]

Gene ID: 15493, updated on 27-Nov-2024

Summary

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Official Symbol
Hsd3b2provided by MGI
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2provided by MGI
Primary source
MGI:MGI:96234
See related
Ensembl:ENSMUSG00000063730 AllianceGenome:MGI:96234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3-beta-HSD II
Summary
Predicted to enable 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity and steroid delta-isomerase activity. Predicted to be involved in C21-steroid hormone biosynthetic process; androgen biosynthetic process; and negative regulation of iron ion transport. Predicted to be located in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 19.0), liver adult (RPKM 15.5) and 3 other tissues See more
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Genomic context

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See Hsd3b2 in Genome Data Viewer
Location:
3 F2.2; 3 42.85 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98618423..98631859, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98711107..98724543, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 pseudogene Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08481 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chaperones rejuvenate folding and activity of 3-β hydroxysteroid dehydrogenase 2. Rajapaksha M, et al. ACS Chem Biol, 2013 May 17. PMID 23485106
  2. The murine 3 beta-hydroxysteroid dehydrogenase multigene family: structure, function and tissue-specific expression. Payne AH, et al. J Steroid Biochem Mol Biol, 1995 Jun. PMID 7626443
  3. The multiple murine 3 beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression. Payne AH, et al. Steroids, 1997 Jan. PMID 9029733
  4. The mouse 3 beta-hydroxysteroid dehydrogenase multigene family includes two functionally distinct groups of proteins. Abbaszade IG, et al. Mol Endocrinol, 1995 Sep. PMID 7491113
  5. Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes. Bain PA, et al. Proc Natl Acad Sci U S A, 1991 Oct 15. PMID 1924345, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. molecular chaperone-assisted folding of 3-beta hydroxysteroid dehydrogenase-2 is a physiological requirement
    Title: Chaperones rejuvenate folding and activity of 3-β hydroxysteroid dehydrogenase 2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid delta-isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid delta-isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in C21-steroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of iron ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Names
3 beta-hydroxysteroid dehydrogenase 2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
hydroxysteroid dehydrogenase-2, delta<5>-3-beta
NP_001346670.1
NP_694873.2
XP_011238327.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359741.1 → NP_001346670.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

    Status: VALIDATED

    Source sequence(s)
    AL606755, BX639392
    Consensus CDS
    CCDS17667.1
    UniProtKB/Swiss-Prot
    B1ARN7, P26149, Q8R0J6
    UniProtKB/TrEMBL
    Q76CU3, Q7TPU0
    Related
    ENSMUSP00000102636.2, ENSMUST00000107022.8
    Conserved Domains (1) summary
    cl25409
    Location:5 → 357
    SDR; Short-chain dehydrogenases/reductases (SDR)

  2. NM_153193.3 → NP_694873.2  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

    See identical proteins and their annotated locations for NP_694873.2

    Status: VALIDATED

    Source sequence(s)
    AL606755, BX639392
    Consensus CDS
    CCDS17667.1
    UniProtKB/Swiss-Prot
    B1ARN7, P26149, Q8R0J6
    UniProtKB/TrEMBL
    Q76CU3, Q7TPU0
    Related
    ENSMUSP00000102635.2, ENSMUST00000107021.8
    Conserved Domains (1) summary
    cl25409
    Location:5 → 357
    SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98618423..98631859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240025.3 → XP_011238327.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 isoform X1

    UniProtKB/TrEMBL
    Q76CU3, Q7TPU0
    Conserved Domains (1) summary
    cl21454
    Location:14 → 316
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26149.4 GenPept UniProtKB/Swiss-Prot:P26149

Gene LinkOut

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