gag-pol Gag-Pol [ Human immunodeficiency virus 1 ]

Gene ID: 155348, updated on 4-Aug-2024

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Summary

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Gene symbol: gag-pol
Gene description: Gag-Pol
Locus tag: HIV1gp1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Human immunodeficiency virus 1
Lineage: Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Sequence:: NC_001802.1 (336..4642)

NC_001802.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001802.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype.
Title: HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype.
Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration.
Title: Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration.
The impact of the M184V resistance mutation on treatment outcomes in patients with HIV infection: a systematic review and meta-analysis.
Title: The impact of the M184V resistance mutation on treatment outcomes in patients with HIV infection: a systematic review and meta-analysis.
Effect of the L74I Polymorphism on Fitness of Cabotegravir-Resistant Variants of Human Immunodeficiency Virus 1 Subtype A6.
Title: Effect of the L74I Polymorphism on Fitness of Cabotegravir-Resistant Variants of Human Immunodeficiency Virus 1 Subtype A6.
HIV-1 reverse transcriptase stability correlates with Gag cleavage efficiency: reverse transcriptase interaction implications for modulating protease activation.
Title: HIV-1 reverse transcriptase stability correlates with Gag cleavage efficiency: reverse transcriptase interaction implications for modulating protease activation.
Genetic and antiretroviral drug resistance mutations analysis of reverse transcriptase and protease gene from Pakistani people living with HIV-1.
Title: Genetic and antiretroviral drug resistance mutations analysis of reverse transcriptase and protease gene from Pakistani people living with HIV-1.
Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase.
Title: Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase.
HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio.
Title: HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio.
Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design.
Title: Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design.
Changes in dynamic and static structures of the HIV-1 p24 capsid protein N-domain caused by amino-acid substitution are associated with its viral viability.
Title: Changes in dynamic and static structures of the HIV-1 p24 capsid protein N-domain caused by amino-acid substitution are associated with its viral viability.

Submit: New GeneRIF Correction See all GeneRIFs (266)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
ATP-citrate synthase isoform 1	ACLY	complexes with	PubMed
fatty acid CoA ligase Acsl3	ACSL3	complexes with	PubMed
actin, cytoplasmic 1	ACTB	complexes with	PubMed
double-stranded RNA-specific adenosine deaminase isoform b	ADAR	complexes with	PubMed
apoptosis-inducing factor 1, mitochondrial isoform AIF precursor	AIFM1	complexes with	PubMed
delta-1-pyrroline-5-carboxylate synthase isoform 1	ALDH18A1	complexes with	PubMed
THO complex subunit 4	ALYREF	complexes with	PubMed
AP-2 complex subunit mu isoform a	AP2M1	complexes with	PubMed
AP-3 complex subunit delta-1 isoform 2	AP3D1	complexes with	PubMed
AP-3 complex subunit sigma-1 isoform 1	AP3S1	complexes with	PubMed
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
ADP-ribosylation factor 4	ARF4	complexes with	PubMed
ADP-ribosylation factor 5	ARF5	complexes with	PubMed
ADP-ribosylation factor 6	ARF6	complexes with	PubMed
ADP-ribosylation factor-like protein 1 isoform 1	ARL1	complexes with	PubMed
actin-related protein 2/3 complex subunit 4 isoform a	ARPC4	complexes with	PubMed
sodium/potassium-transporting ATPase subunit alpha-1 isoform a	ATP1A1	complexes with	PubMed
ATP synthase subunit alpha, mitochondrial isoform a precursor	ATP5F1A	complexes with	PubMed
ATP synthase subunit gamma, mitochondrial isoform H (heart) precursor	ATP5F1C	complexes with	PubMed
ATP synthase subunit O, mitochondrial precursor	ATP5PO	complexes with	PubMed
V-type proton ATPase subunit d 1	ATP6V0D1	complexes with	PubMed
multifunctional protein CAD isoform 1	CAD	complexes with	PubMed
calnexin isoform d precursor	CANX	complexes with	PubMed
caprin-1 isoform 1	CAPRIN1	complexes with	PubMed
T-complex protein 1 subunit beta isoform 1	CCT2	complexes with	PubMed
T-complex protein 1 subunit delta isoform a	CCT4	complexes with	PubMed
cell division cycle 5-like protein	CDC5L	complexes with	PubMed
CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1	CDIPT	complexes with	PubMed
MHC class II transactivator isoform 2	CIITA	upregulates	PubMed
clathrin light chain A isoform a	CLTA	incorporates	PubMed
clathrin light chain B isoform a	CLTB	incorporates	PubMed
clathrin heavy chain 1 isoform 1	CLTC	complexes with	PubMed
	CLTC	incorporates	PubMed
coatomer subunit alpha isoform 2	COPA	complexes with	PubMed
coatomer subunit zeta-1 isoform 1	COPZ1	complexes with	PubMed
copine-3	CPNE3	complexes with	PubMed
cleavage and polyadenylation specificity factor subunit 1	CPSF1	complexes with	PubMed
cleavage and polyadenylation specificity factor subunit 7 isoform 1	CPSF7	complexes with	PubMed
aspartate--tRNA ligase, cytoplasmic isoform 1	DARS1	complexes with	PubMed
dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor	DDOST	complexes with	PubMed
ATP-dependent RNA helicase DDX1	DDX1	complexes with	PubMed
probable ATP-dependent RNA helicase DDX17 isoform 1 precursor	DDX17	regulated by	PubMed
	DDX17	complexes with	PubMed
nucleolar RNA helicase 2 isoform 1	DDX21	complexes with	PubMed
probable ATP-dependent RNA helicase DDX23	DDX23	complexes with	PubMed
probable ATP-dependent RNA helicase DDX27 isoform 2	DDX27	complexes with	PubMed
spliceosome RNA helicase DDX39B	DDX39B	complexes with	PubMed
ATP-dependent RNA helicase DDX3X isoform 1	DDX3X	complexes with	PubMed
probable ATP-dependent RNA helicase DDX5 isoform a	DDX5	complexes with	PubMed
7-dehydrocholesterol reductase isoform 1	DHCR7	complexes with	PubMed
ATP-dependent RNA helicase DHX15	DHX15	complexes with	PubMed
ATP-dependent RNA helicase DHX30 isoform 2	DHX30	complexes with	PubMed
ATP-dependent RNA helicase A	DHX9	regulated by	PubMed
	DHX9	complexes with	PubMed
dynamin-2 isoform 3	DNM2	complexes with	PubMed
developmentally-regulated GTP-binding protein 1	DRG1	complexes with	PubMed
elongation factor 1-alpha 1	EEF1A1	complexes with	PubMed
elongation factor 1-delta isoform 1	EEF1D	complexes with	PubMed
elongation factor 1-gamma	EEF1G	complexes with	PubMed
eukaryotic translation initiation factor 3 subunit A	EIF3A	complexes with	PubMed
eukaryotic translation initiation factor 3 subunit D	EIF3D	complexes with	PubMed
eukaryotic translation initiation factor 3 subunit E	EIF3E	complexes with	PubMed
eukaryotic initiation factor 4A-I isoform 1	EIF4A1	complexes with	PubMed
eukaryotic initiation factor 4A-III isoform 1	EIF4A3	complexes with	PubMed
ELAV-like protein 1	ELAVL1	complexes with	PubMed
alpha-enolase isoform 1	ENO1	complexes with	PubMed
bifunctional glutamate/proline--tRNA ligase	EPRS1	complexes with	PubMed
eukaryotic peptide chain release factor subunit 1 isoform 1	ETF1	modulated by	PubMed
electron transfer flavoprotein subunit beta isoform 1	ETFB	complexes with	PubMed
fatty acid synthase	FASN	complexes with	PubMed
pre-mRNA 3'-end-processing factor FIP1 isoform 1	FIP1L1	complexes with	PubMed
filamin-A isoform 1	FLNA	complexes with	PubMed
glyceraldehyde-3-phosphate dehydrogenase isoform 1	GAPDH	interacts with	PubMed
	GAPDH	complexes with	PubMed
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform 1	HACD3	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein A0	HNRNPA0	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein A1 isoform a	HNRNPA1	complexes with	PubMed
heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2	HNRNPA2B1	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein A3 isoform a	HNRNPA3	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein A/B isoform b	HNRNPAB	complexes with	PubMed
heterogeneous nuclear ribonucleoproteins C1/C2 isoform b	HNRNPC	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein D0 isoform c	HNRNPD	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein F	HNRNPF	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein H isoform a	HNRNPH1	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein H2	HNRNPH2	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein H3 isoform a	HNRNPH3	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein K isoform a	HNRNPK	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein M isoform a	HNRNPM	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein R isoform 2	HNRNPR	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein U isoform b	HNRNPU	complexes with	PubMed
peroxisomal multifunctional enzyme type 2 isoform 2	HSD17B4	complexes with	PubMed
heat shock protein HSP 90-alpha isoform 2	HSP90AA1	incorporates	PubMed
heat shock protein HSP 90-beta isoform a	HSP90AB1	incorporates	PubMed
heat shock 70 kDa protein 1A	HSPA1A	complexes with	PubMed
heat shock 70 kDa protein 1B	HSPA1B	complexes with	PubMed
heat shock 70 kDa protein 1-like	HSPA1L	complexes with	PubMed
endoplasmic reticulum chaperone BiP precursor	HSPA5	complexes with	PubMed
heat shock cognate 71 kDa protein isoform 1	HSPA8	complexes with	PubMed
stress-70 protein, mitochondrial precursor	HSPA9	complexes with	PubMed
60 kDa heat shock protein, mitochondrial	HSPD1	complexes with	PubMed
E3 ubiquitin-protein ligase HUWE1	HUWE1	interacts with	PubMed
isoleucine--tRNA ligase, cytoplasmic isoform 1	IARS1	complexes with	PubMed
isocitrate dehydrogenase	IDH3A	complexes with	PubMed
insulin-like growth factor 2 mRNA-binding protein 1 isoform 1	IGF2BP1	complexes with	PubMed
insulin-like growth factor 2 mRNA-binding protein 3	IGF2BP3	complexes with	PubMed
interleukin enhancer-binding factor 2 isoform 1	ILF2	complexes with	PubMed
interleukin enhancer-binding factor 3 isoform b	ILF3	complexes with	PubMed
alpha-internexin	INA	complexes with	PubMed
importin-7	IPO7	complexes with	PubMed
ras GTPase-activating-like protein IQGAP1	IQGAP1	complexes with	PubMed
lysine--tRNA ligase isoform 2	KARS1	associates with	PubMed
far upstream element-binding protein 2 isoform 1	KHSRP	complexes with	PubMed
importin subunit beta-1 isoform 1	KPNB1	complexes with	PubMed
KRR1 small subunit processome component homolog	KRR1	complexes with	PubMed
leucine--tRNA ligase, cytoplasmic isoform 1	LARS1	complexes with	PubMed
L-lactate dehydrogenase A chain isoform 1	LDHA	complexes with	PubMed
L-lactate dehydrogenase B chain isoform LDHB	LDHB	complexes with	PubMed
leucine-rich PPR motif-containing protein, mitochondrial precursor	LRPPRC	complexes with	PubMed
leucine-rich repeat-containing protein 59	LRRC59	complexes with	PubMed
putative RNA-binding protein Luc7-like 2 isoform 1	LUC7L2	complexes with	PubMed
lysozyme C precursor	LYZ	complexes with	PubMed
matrin-3 isoform a	MATR3	complexes with	PubMed
DNA replication licensing factor MCM7 isoform 1	MCM7	complexes with	PubMed
mannosyl-oligosaccharide glucosidase isoform 1	MOGS	complexes with	PubMed
helicase MOV-10 isoform 1	MOV10	complexes with	PubMed
myb-binding protein 1A isoform 2	MYBBP1A	complexes with	PubMed
nucleolin	NCL	complexes with	PubMed
NF-kappa-B-repressing factor isoform 2	NKRF	complexes with	PubMed
non-POU domain-containing octamer-binding protein isoform 1	NONO	complexes with	PubMed
nucleophosmin isoform 1	NPM1	complexes with	PubMed
vesicle-fusing ATPase	NSF	complexes with	PubMed
cleavage and polyadenylation specificity factor subunit 5	NUDT21	complexes with	PubMed
nuclear pore complex protein Nup155 isoform 2	NUP155	complexes with	PubMed
ornithine aminotransferase, mitochondrial isoform 1 precursor	OAT	complexes with	PubMed
polyadenylate-binding protein 1	PABPC1	complexes with	PubMed
polyadenylate-binding protein 4 isoform 2	PABPC4	complexes with	PubMed
polyadenylate-binding protein 2 isoform 1	PABPN1	complexes with	PubMed
poly(rC)-binding protein 1	PCBP1	complexes with	PubMed
pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform 1 precursor	PDHB	complexes with	PubMed
prohibitin 1 isoform 1	PHB1	complexes with	PubMed
prohibitin-2 isoform 1	PHB2	complexes with	PubMed
pyruvate kinase PKM isoform a	PKM	complexes with	PubMed
plastin-3 isoform 1	PLS3	complexes with	PubMed
peroxiredoxin-6	PRDX6	complexes with	PubMed
DNA-dependent protein kinase catalytic subunit isoform 1	PRKDC	complexes with	PubMed
pre-mRNA-processing factor 40 homolog A isoform 1	PRPF40A	complexes with	PubMed
pre-mRNA-processing-splicing factor 8	PRPF8	complexes with	PubMed
26S proteasome regulatory subunit 10B	PSMC6	complexes with	PubMed
26S proteasome non-ATPase regulatory subunit 2 isoform 1	PSMD2	complexes with	PubMed
small ribosomal subunit protein mS39 precursor	PTCD3	complexes with	PubMed
phosphatidylserine synthase 1 isoform 1	PTDSS1	complexes with	PubMed
glycogen phosphorylase, liver form isoform 1	PYGL	complexes with	PubMed
ras-related protein Rab-10	RAB10	complexes with	PubMed
ras-related protein Rab-5C isoform a	RAB5C	complexes with	PubMed
ras-related protein Rab-8A	RAB8A	complexes with	PubMed
small ribosomal subunit protein RACK1	RACK1	complexes with	PubMed
GTP-binding nuclear protein Ran isoform 1	RAN	complexes with	PubMed
ribonucleoprotein PTB-binding 1	RAVER1	complexes with	PubMed
RNA-binding motif protein, X chromosome isoform 1	RBMX	complexes with	PubMed
E3 ubiquitin-protein ligase BRE1A	RNF20	complexes with	PubMed
large ribosomal subunit protein uL16 isoform a	RPL10	complexes with	PubMed
large ribosomal subunit protein eL13 isoform 1	RPL13	complexes with	PubMed
large ribosomal subunit protein eL14	RPL14	complexes with	PubMed
large ribosomal subunit protein uL22 isoform a	RPL17	complexes with	PubMed
large ribosomal subunit protein eL18 isoform 1	RPL18	complexes with	PubMed
large ribosomal subunit protein eL19 isoform 1	RPL19	complexes with	PubMed
large ribosomal subunit protein eL24	RPL24	complexes with	PubMed
large ribosomal subunit protein eL29	RPL29	complexes with	PubMed
large ribosomal subunit protein uL3 isoform a	RPL3	complexes with	PubMed
large ribosomal subunit protein uL4	RPL4	complexes with	PubMed
large ribosomal subunit protein uL18	RPL5	complexes with	PubMed
large ribosomal subunit protein eL6 isoform 1	RPL6	complexes with	PubMed
large ribosomal subunit protein uL30 isoform 1	RPL7	complexes with	PubMed
large ribosomal subunit protein eL8	RPL7A	complexes with	PubMed
large ribosomal subunit protein uL2	RPL8	complexes with	PubMed
large ribosomal subunit protein uL6	RPL9	complexes with	PubMed
large ribosomal subunit protein uL10	RPLP0	complexes with	PubMed
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor	RPN1	complexes with	PubMed
small ribosomal subunit protein uS5	RPS2	complexes with	PubMed
small ribosomal subunit protein uS3 isoform 1	RPS3	complexes with	PubMed
small ribosomal subunit protein eS4, X isoform	RPS4X	complexes with	PubMed
small ribosomal subunit protein eS6	RPS6	complexes with	PubMed
small ribosomal subunit protein eS8	RPS8	complexes with	PubMed
small ribosomal subunit protein uS4 isoform a	RPS9	complexes with	PubMed
ras-related GTP-binding protein A	RRAGA	complexes with	PubMed
scaffold attachment factor B1 isoform 3	SAFB	complexes with	PubMed
U4/U6.U5 tri-snRNP-associated protein 1	SART1	complexes with	PubMed
protein transport protein Sec61 subunit alpha isoform 1 isoform 1	SEC61A1	complexes with	PubMed
serpin H1 precursor	SERPINH1	complexes with	PubMed
splicing factor 3B subunit 1 isoform 1	SF3B1	complexes with	PubMed
splicing factor 3B subunit 2	SF3B2	complexes with	PubMed
splicing factor 3B subunit 4	SF3B4	complexes with	PubMed
splicing factor, proline- and glutamine-rich	SFPQ	complexes with	PubMed
sideroflexin-1 isoform 1	SFXN1	complexes with	PubMed
mitochondrial 2-oxoglutarate/malate carrier protein isoform 1	SLC25A11	complexes with	PubMed
ADP/ATP translocase 2	SLC25A5	complexes with	PubMed
structural maintenance of chromosomes protein 1A isoform 1	SMC1A	complexes with	PubMed
U5 small nuclear ribonucleoprotein 200 kDa helicase	SNRNP200	complexes with	PubMed
spectrin alpha chain, non-erythrocytic 1 isoform 2	SPTAN1	complexes with	PubMed
signal recognition particle subunit SRP68 isoform 1	SRP68	complexes with	PubMed
signal recognition particle subunit SRP72 isoform 1	SRP72	complexes with	PubMed
signal recognition particle receptor subunit beta	SRPRB	complexes with	PubMed
serine/arginine-rich splicing factor 1 isoform 1	SRSF1	complexes with	PubMed
serine/arginine-rich splicing factor 10 isoform 1	SRSF10	complexes with	PubMed
serine/arginine-rich splicing factor 4	SRSF4	complexes with	PubMed
serine/arginine-rich splicing factor 7 isoform 1	SRSF7	complexes with	PubMed
double-stranded RNA-binding protein Staufen homolog 1 isoform a	STAU1	complexes with	PubMed
heterogeneous nuclear ribonucleoprotein Q isoform 1	SYNCRIP	complexes with	PubMed
RISC-loading complex subunit TARBP2 isoform b	TARBP2	interacts with	PubMed
TAR DNA-binding protein 43	TARDBP	complexes with	PubMed
T-complex protein 1 subunit alpha isoform a	TCP1	complexes with	PubMed
THO complex subunit 2	THOC2	complexes with	PubMed
transcription intermediary factor 1-beta	TRIM28	complexes with	PubMed
tubulin alpha-1A chain isoform 1	TUBA1A	complexes with	PubMed
tubulin alpha-4A chain isoform 1	TUBA4A	complexes with	PubMed
regulator of nonsense transcripts 1 isoform 2	UPF1	complexes with	PubMed
regulator of nonsense transcripts 3B isoform 2	UPF3B	complexes with	PubMed
vimentin	VIM	complexes with	PubMed
Y-box-binding protein 1	YBX1	complexes with	PubMed
zinc finger RNA-binding protein	ZFR	complexes with	PubMed
A-kinase anchor protein 8-like isoform 1	AKAP8L	incorporates	PubMed
anaphase-promoting complex subunit 2	ANAPC2	interacts with	PubMed
DNA dC->dU-editing enzyme APOBEC-3F isoform a	APOBEC3F	interacts with	PubMed
beta-arrestin-2 isoform 1	ARRB2	interacts with	PubMed
autophagy-related protein 16-1 isoform 2	ATG16L1	interacts with	PubMed
protein Atg16l2 isoform 1	ATG16L2	interacts with	PubMed
cell cycle and apoptosis regulator protein 2 isoform 1	CCAR2	interacts with	PubMed
T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor	CD8A	inhibits	PubMed
T-cell surface glycoprotein CD8 beta chain isoform 5 precursor	CD8B	inhibits	PubMed
	CLTA	stabilized by	PubMed
	CLTB	stabilized by	PubMed
	CLTC	stabilized by	PubMed
	EIF3A	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit B isoform 1	EIF3B	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit C isoform a	EIF3C	interacts with	PubMed
	EIF3D	interacts with	PubMed
	EIF3E	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit F	EIF3F	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit G	EIF3G	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit H	EIF3H	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit I isoform 1	EIF3I	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit K isoform 1	EIF3K	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit L isoform 1	EIF3L	interacts with	PubMed
ferrochelatase, mitochondrial isoform b precursor	FECH	interacts with	PubMed
growth factor receptor-bound protein 2 isoform 1	GRB2	interacts with	PubMed
HLA class I histocompatibility antigen, A alpha chain isoform A*03:01:01:01 precursor	HLA-A	binds	PubMed
	HSPD1	interacts with	PubMed
	IDH3A	interacts with	PubMed
interleukin-10 isoform 1 precursor	IL10	regulated by	PubMed
	IPO7	interacts with	PubMed
	KARS1	interacts with	PubMed
	KARS1	binds	PubMed
galectin-3-binding protein precursor	LGALS3BP	interacts with	PubMed
LIM domain-containing protein 1	LIMD1	interacts with	PubMed
DNA replication licensing factor MCM4	MCM4	interacts with	PubMed
DNA replication licensing factor MCM6	MCM6	interacts with	PubMed
	MCM7	interacts with	PubMed
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 1	NFU1	interacts with	PubMed
nuclear migration protein nudC	NUDC	interacts with	PubMed
oxysterol-binding protein-related protein 3 isoform a	OSBPL3	interacts with	PubMed
protein disulfide-isomerase A4 isofrom 2 precursor	PDIA4	interacts with	PubMed
protein disulfide-isomerase A6 isoform d precursor	PDIA6	interacts with	PubMed
protein pelota homolog	PELO	interacts with	PubMed
POU domain, class 2, transcription factor 1 isoform 1	POU2F1	interacts with	PubMed
POU domain, class 2, transcription factor 2 isoform 2	POU2F2	interacts with	PubMed
serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	interacts with	PubMed
PC4 and SFRS1-interacting protein isoform 1	PSIP1	recruits	PubMed
	PSIP1	interacts with	PubMed
reticulocalbin-1 precursor	RCN1	interacts with	PubMed
ATP-dependent DNA helicase Q1	RECQL	interacts with	PubMed
ribonucleoside-diphosphate reductase subunit M2 isoform 2	RRM2	interacts with	PubMed
ruvB-like 1 isoform 1	RUVBL1	interacts with	PubMed
transcription factor Sp1 isoform b	SP1	interacts with	PubMed
transcription factor Sp3 isoform 1	SP3	interacts with	PubMed
transcription factor PU.1 isoform 2	SPI1	interacts with	PubMed
succinate--CoA ligase	SUCLG2	interacts with	PubMed
5,6-dihydroxyindole-2-carboxylic acid oxidase precursor	TYRP1	interacts with	PubMed
peroxisomal leader peptide-processing protease isoform a	TYSND1	interacts with	PubMed
E3 ubiquitin-protein ligase UBR2 isoform 1	UBR2	interacts with	PubMed
E3 ubiquitin-protein ligase UBR4	UBR4	interacts with	PubMed
ATP-dependent translocase ABCB1 isoform 2	ABCB1	interacts with	PubMed
disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein	ADAM10	co-localizes with	PubMed
alkaline phosphatase, placental type preproprotein	ALPP	interacts with	PubMed
ankyrin repeat domain-containing protein 13C	ANKRD13C	interacts with	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	complexes with	PubMed
serine-protein kinase ATM isoform a	ATM	interacts with	PubMed
	ATM	interacts with	PubMed
V-type proton ATPase subunit G 3 isoform a	ATP6V1G3	interacts with	PubMed
serine/threonine-protein kinase ATR isoform 1	ATR	interacts with	PubMed
transcription regulator protein BACH2	BACH2	interacts with	PubMed
barrier-to-autointegration factor	BANF1	interacts with	PubMed
	BANF1	interacts with	PubMed
transcription factor BTF3 isoform B	BTF3	binds	PubMed
C2 domain-containing protein 3 isoform 2	C2CD3	interacts with	PubMed
cullin-associated NEDD8-dissociated protein 2 isoform 2	CAND2	interacts with	PubMed
coiled-coil domain-containing protein 32 isoform 2	CCDC32	binds	PubMed
	CCT4	binds	PubMed
cell division cycle-associated 7-like protein isoform 1	CDCA7L	co-localizes with	PubMed
	CDCA7L	binds	PubMed
	CDCA7L	overlaps	PubMed
	CDCA7L	binds	PubMed
cyclin-dependent kinase inhibitor 1 isoform 1	CDKN1A	complexes with	PubMed
choline/ethanolaminephosphotransferase 1 isoform 1	CEPT1	interacts with	PubMed
probable cytosolic iron-sulfur protein assembly protein CIAO1	CIAO1	interacts with	PubMed
cytosolic iron-sulfur assembly component 2B	CIAO2B	interacts with	PubMed
cytoskeleton-associated protein 5 isoform b	CKAP5	interacts with	PubMed
creatine kinase U-type, mitochondrial isoform 1 precursor	CKMT1A	interacts with	PubMed
creatine kinase U-type, mitochondrial precursor	CKMT1B	interacts with	PubMed
	CLTA	incorporates	PubMed
	CLTA	incorporates	PubMed
	CLTB	incorporates	PubMed
	CLTB	incorporates	PubMed
	CLTC	incorporates	PubMed
	CLTC	incorporates	PubMed
CREB-binding protein isoform a	CREBBP	interacts with	PubMed
gamma-crystallin S	CRYGS	interacts with	PubMed
exportin-2 isoform 1	CSE1L	binds	PubMed
cystatin-C precursor	CST3	interacts with	PubMed
interleukin-8 isoform 1 precursor	CXCL8	interacts with	PubMed
	CXCL8	interacts with	PubMed
death domain-associated protein 6 isoform a	DAXX	interacts with	PubMed
	DAXX	interacts with	PubMed
probable ATP-dependent RNA helicase DDX6 isoform 1	DDX6	interacts with	PubMed
desmoplakin isoform I	DSP	interacts with	PubMed
dynein light chain 1, cytoplasmic	DYNLL1	interacts with	PubMed
	DYNLL1	interacts with	PubMed
	DYNLL1	interacts with	PubMed
	DYNLL1	interacts with	PubMed
polycomb protein EED isoform a	EED	binds	PubMed
	EED	interacts with	PubMed
	EED	stimulated by	PubMed
	EEF1A1	interacts with	PubMed
	EEF1A1	binds	PubMed
	EEF1A1	binds	PubMed
	EEF1G	interacts with	PubMed
eIF-2-alpha kinase GCN2	EIF2AK4	binds	PubMed
	EIF3H	binds	PubMed
emerin	EMD	interacts with	PubMed
histone acetyltransferase p300 isoform 1	EP300	acetylated by	PubMed
	EP300	acetylated by	PubMed
tumor necrosis factor receptor superfamily member 6 isoform 1 precursor	FAS	interacts with	PubMed
flap endonuclease 1	FEN1	stimulates	PubMed
fibrous sheath-interacting protein 1	FSIP1	interacts with	PubMed
gem-associated protein 2 isoform alpha	GEMIN2	interacts with	PubMed
	GEMIN2	interacts with	PubMed
	GEMIN2	binds	PubMed
histone H2AX	H2AX	induces phosphorylation of	PubMed
histone deacetylase 1	HDAC1	complexes with	PubMed
	HDAC1	complexes with	PubMed
5'-deoxynucleotidase HDDC2	HDDC2	interacts with	PubMed
hepatoma-derived growth factor-related protein 2 isoform 2	HDGFL2	activated by	PubMed
	HDGFL2	interacts with	PubMed
	HDGFL2	interacts with	PubMed
	HDGFL2	co-localizes with	PubMed
HEAT repeat-containing protein 1	HEATR1	interacts with	PubMed
high mobility group protein HMG-I/HMG-Y isoform b	HMGA1	stimulated by	PubMed
non-histone chromosomal protein HMG-17	HMGN2	binds	PubMed
	HNRNPA2B1	binds	PubMed
	HNRNPM	interacts with	PubMed
heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform a	HNRNPUL1	interacts with	PubMed
HORMA domain-containing protein 2 isoform a	HORMAD2	interacts with	PubMed
	HSPD1	stimulated by	PubMed
10 kDa heat shock protein, mitochondrial	HSPE1	interacts with	PubMed
	HUWE1	interacts with	PubMed
zinc finger protein Aiolos isoform 1	IKZF3	interacts with	PubMed
interleukin-15 isoform 1 preproprotein	IL15	enhanced by	PubMed
interleukin-1 beta proprotein	IL1B	interacts with	PubMed
interleukin-2 precursor	IL2	enhanced by	PubMed
interleukin-4 isoform 1 precursor	IL4	enhanced by	PubMed
interleukin-7 isoform 1 precursor	IL7	interacts with	PubMed
	IL7	enhanced by	PubMed
importin-4	IPO4	interacts with	PubMed
importin-5	IPO5	imported by	PubMed
	IPO5	binds	PubMed
	IPO5	imported by	PubMed
	IPO7	binds	PubMed
	IPO7	imported by	PubMed
protein IWS1 homolog isoform 1	IWS1	binds	PubMed
	IWS1	displaces	PubMed
	IWS1	overlaps	PubMed
histone acetyltransferase KAT2A isoform 1	KAT2A	binds	PubMed
	KAT2A	acetylated by	PubMed
histone acetyltransferase KAT6A isoform 1	KAT6A	acetylated by	PubMed
histone acetyltransferase KAT6B isoform 1	KAT6B	acetylated by	PubMed
histone acetyltransferase KAT7 isoform 1	KAT7	acetylated by	PubMed
histone acetyltransferase KAT8 isoform 1	KAT8	acetylated by	PubMed
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 1	KCTD13	interacts with	PubMed
dyslexia-associated protein KIAA0319-like protein	KIAA0319L	interacts with	PubMed
kinesin-associated protein 3 isoform 1	KIFAP3	binds	PubMed
histone-lysine N-methyltransferase 2A isoform 1	KMT2A	binds	PubMed
importin subunit alpha-5	KPNA1	interacts with	PubMed
	KPNA1	complexes with	PubMed
	KPNA1	imported by	PubMed
	KPNA1	binds	PubMed
	KPNA1	imported by	PubMed
importin subunit alpha-1	KPNA2	imported by	PubMed
	KPNA2	interacts with	PubMed
	KPNA2	interacts with	PubMed
	KPNA2	complexes with	PubMed
	KPNA2	imported by	PubMed
	KPNA2	binds	PubMed
importin subunit alpha-4	KPNA3	imported by	PubMed
	KPNA3	interacts with	PubMed
	KPNA3	complexes with	PubMed
	KPNA3	imported by	PubMed
	KPNA3	binds	PubMed
importin subunit alpha-3	KPNA4	binds	PubMed
	KPNA4	interacts with	PubMed
	KPNA4	binds	PubMed
	KPNA4	complexes with	PubMed
	KPNA4	imported by	PubMed
	KPNA4	binds	PubMed
	KPNA4	imported by	PubMed
importin subunit alpha-6 isoform b	KPNA5	interacts with	PubMed
	KPNA5	complexes with	PubMed
	KPNA5	imported by	PubMed
	KPNA5	binds	PubMed
	KPNA5	imported by	PubMed
importin subunit alpha-7	KPNA6	imported by	PubMed
	KPNA6	imported by	PubMed
	KPNA6	binds	PubMed
	KPNB1	interacts with	PubMed
	KPNB1	imported by	PubMed
	KPNB1	binds	PubMed
	KPNB1	imported by	PubMed
	LRPPRC	associates with	PubMed
mitogen-activated protein kinase 1	MAPK1	interacts with	PubMed
mitogen-activated protein kinase 8 isoform beta2	MAPK8	phosphorylated by	PubMed
	MCM6	interacts with	PubMed
myocardin-related transcription factor B isoform 2	MRTFB	interacts with	PubMed
interferon-induced GTP-binding protein Mx2	MX2	interacts with	PubMed
NACHT, LRR and PYD domains-containing protein 3 isoform a	NLRP3	interacts with	PubMed
nuclear pore complex protein Nup153 isoform 2	NUP153	interacts with	PubMed
	NUP153	interacts with	PubMed
	NUP153	interacts with	PubMed
	NUP153	binds	PubMed
nuclear pore glycoprotein p62	NUP62	binds	PubMed
nuclear pore complex protein Nup98-Nup96 isoform 1 precursor	NUP98	cooperates with	PubMed
nuclear transport factor 2	NUTF2	inhibited by	PubMed
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial isoform 3 precursor	OXCT1	interacts with	PubMed
polyadenylate-binding protein 1-like	PABPC1L	interacts with	PubMed
poly	PARP1	requires	PubMed
phosphoenolpyruvate carboxykinase, cytosolic	PCK1	binds	PubMed
	PDIA4	interacts with	PubMed
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	PIN1	binds	PubMed
	PIN1	binds	PubMed
plakophilin-4 isoform a	PKP4	interacts with	PubMed
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform 2 precursor	PLOD1	interacts with	PubMed
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor	PLOD2	interacts with	PubMed
protein PML isoform 1	PML	interacts with	PubMed
pogo transposable element with ZNF domain isoform 1	POGZ	binds	PubMed
	POGZ	overlaps	PubMed
	POGZ	displaces	PubMed
	POGZ	competes with	PubMed
peptidyl-prolyl cis-trans isomerase A isoform 1	PPIA	incorporates	PubMed
	PRKDC	interacts with	PubMed
	PRKDC	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	binds	PubMed
	PSIP1	binds	PubMed
	PSIP1	binds	PubMed
	PSIP1	overlaps	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	co-localizes with	PubMed
	PSIP1	stimulated by	PubMed
	PSIP1	fractionates with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	competes with	PubMed
	PSIP1	stabilized by	PubMed
	PSIP1	binds	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	induces accumulation of	PubMed
	PSIP1	binds	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	complexes with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	upregulates	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	inhibited by	PubMed
	PSIP1	imported by	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	binds	PubMed
	PSIP1	binds	PubMed
	PSIP1	binds	PubMed
	PSIP1	binds	PubMed
	PSIP1	regulated by	PubMed
	PSIP1	binds	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	complexes with	PubMed
	PSIP1	complexes with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	complexes with	PubMed
	PSIP1	complexes with	PubMed
	PSIP1	complexes with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
	PSIP1	interacts with	PubMed
proteasome subunit alpha type-2	PSMA2	degraded by	PubMed
proteasome subunit alpha type-3 isoform 1	PSMA3	degraded by	PubMed
proteasome subunit alpha type-5 isoform 1	PSMA5	degraded by	PubMed
proteasome subunit alpha type-6 isoform a	PSMA6	degraded by	PubMed
proteasome subunit alpha type-7	PSMA7	degraded by	PubMed
proteasome subunit beta type-1	PSMB1	degraded by	PubMed
proteasome subunit beta type-10	PSMB10	degraded by	PubMed
proteasome subunit beta type-2 isoform 1	PSMB2	degraded by	PubMed
proteasome subunit beta type-3	PSMB3	degraded by	PubMed
proteasome subunit beta type-4	PSMB4	degraded by	PubMed
proteasome subunit beta type-5 isoform 1	PSMB5	degraded by	PubMed
proteasome subunit beta type-6 isoform 1	PSMB6	degraded by	PubMed
proteasome subunit beta type-7 precursor	PSMB7	degraded by	PubMed
proteasome subunit beta type-8 isoform E1	PSMB8	degraded by	PubMed
26S proteasome regulatory subunit 4 isoform a	PSMC1	degraded by	PubMed
26S proteasome regulatory subunit 7 isoform 1	PSMC2	degraded by	PubMed
26S proteasome regulatory subunit 6A	PSMC3	degraded by	PubMed
26S proteasome regulatory subunit 6B isoform 1	PSMC4	degraded by	PubMed
26S proteasome regulatory subunit 8 isoform 1	PSMC5	degraded by	PubMed
	PSMC6	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 1 isoform 1	PSMD1	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 10 isoform 1	PSMD10	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 11	PSMD11	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 12 isoform 1	PSMD12	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 13 isoform 1	PSMD13	degraded by	PubMed
	PSMD2	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 3	PSMD3	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 4 isoform 2	PSMD4	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 5 isoform 1	PSMD5	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 6 isoform 2	PSMD6	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 7	PSMD7	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 8	PSMD8	degraded by	PubMed
26S proteasome non-ATPase regulatory subunit 9 isoform 1	PSMD9	degraded by	PubMed
proteasome activator complex subunit 1 isoform 1	PSME1	degraded by	PubMed
proteasome activator complex subunit 2	PSME2	degraded by	PubMed
proteasome activator complex subunit 3 isoform 1	PSME3	degraded by	PubMed
proteasome activator complex subunit 4	PSME4	degraded by	PubMed
proteasome inhibitor PI31 subunit isoform 1	PSMF1	degraded by	PubMed
E3 ubiquitin-protein ligase RAD18	RAD18	interacts with	PubMed
DNA repair protein RAD51 homolog 1 isoform 1	RAD51	inhibited by	PubMed
	RAD51	inhibited by	PubMed
	RAN	inhibited by	PubMed
E3 SUMO-protein ligase RanBP2 isoform 1	RANBP2	interacts with	PubMed
ran-binding protein 6 isoform 1	RANBP6	interacts with	PubMed
ran-binding protein 9	RANBP9	binds	PubMed
putative RNA-binding protein 15B	RBM15B	interacts with	PubMed
ret finger protein-like 3 isoform 2	RFPL3	interacts with	PubMed
large ribosomal subunit protein uL14	RPL23	binds	PubMed
histone deacetylase complex subunit SAP18 isoform 1	SAP18	binds	PubMed
	SAP18	binds	PubMed
paired amphipathic helix protein Sin3a	SIN3A	recruits	PubMed
superkiller complex protein 8 isoform a	SKIC8	interacts with	PubMed
zinc transporter 7	SLC30A7	interacts with	PubMed
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform a	SMARCB1	interacts with	PubMed
	SMARCB1	inhibited by	PubMed
	SMARCB1	complexes with	PubMed
	SMARCB1	interacts with	PubMed
	SMARCB1	binds	PubMed
	SMARCB1	stimulated by	PubMed
	SMARCB1	binds	PubMed
	SMARCB1	interacts with	PubMed
	SMARCB1	interacts with	PubMed
	SMARCB1	recruits	PubMed
	SMARCB1	interacts with	PubMed
	SMARCB1	inhibited by	PubMed
	SMARCB1	binds	PubMed
	SMARCB1	stimulated by	PubMed
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor	ST8SIA4	interacts with	PubMed
signal transducer and activator of transcription 5B	STAT5B	interacts with	PubMed
stathmin isoform a	STMN1	binds	PubMed
	SUCLG2	interacts with	PubMed
small ubiquitin-related modifier 1 isoform a precursor	SUMO1	sumoylated by	PubMed
	SUMO1	interacts with	PubMed
small ubiquitin-related modifier 2 isoform a precursor	SUMO2	sumoylated by	PubMed
	SUMO2	interacts with	PubMed
small ubiquitin-related modifier 3 isoform 1 precursor	SUMO3	sumoylated by	PubMed
tyrosyl-DNA phosphodiesterase 2	TDP2	interacts with	PubMed
thyroid hormone receptor-associated protein 3 isoform 1	THRAP3	binds	PubMed
tumor necrosis factor ligand superfamily member 13B isoform 1	TNFSF13B	interacts with	PubMed
transportin-1 isoform 1	TNPO1	imported by	PubMed
	TNPO1	binds	PubMed
	TNPO1	imported by	PubMed
transportin-3 isoform 1	TNPO3	binds	PubMed
	TNPO3	binds	PubMed
	TNPO3	interacts with	PubMed
	TNPO3	binds	PubMed
	TNPO3	binds	PubMed
	TNPO3	binds	PubMed
	TNPO3	complexes with	PubMed
cellular tumor antigen p53 isoform a	TP53	induces phosphorylation of	PubMed
trafficking protein particle complex subunit 10 isoform a	TRAPPC10	interacts with	PubMed
	TRIM28	inhibited by	PubMed
	TRIM28	interacts with	PubMed
	TUBA1A	interacts with	PubMed
tubulin alpha-1B chain	TUBA1B	interacts with	PubMed
tubulin alpha-1C chain isoform c	TUBA1C	interacts with	PubMed
tubulin alpha-3C chain	TUBA3C	interacts with	PubMed
tubulin alpha-3D chain	TUBA3D	interacts with	PubMed
tubulin alpha-3E chain	TUBA3E	interacts with	PubMed
	TUBA4A	interacts with	PubMed
tubulin alpha-8 chain isoform 1	TUBA8	interacts with	PubMed
	TYSND1	interacts with	PubMed
ubiquitin-like modifier-activating enzyme 1	UBA1	interacts with	PubMed
ubiquitin-conjugating enzyme E2 D2 isoform 1	UBE2D2	interacts with	PubMed
SUMO-conjugating enzyme UBC9	UBE2I	interacts with	PubMed
protein unc-45 homolog A isoform 2	UNC45A	interacts with	PubMed
uracil-DNA glycosylase isoform UNG2	UNG	incorporates	PubMed
	UNG	binds	PubMed
prefoldin subunit 3 isoform 1	VBP1	binds	PubMed
X-ray repair cross-complementing protein 5	XRCC5	associates with	PubMed
	XRCC5	interacts with	PubMed
X-ray repair cross-complementing protein 6 isoform 1	XRCC6	stabilized by	PubMed
	XRCC6	binds	PubMed
	XRCC6	associates with	PubMed
	XRCC6	interacts with	PubMed
14-3-3 protein beta/alpha	YWHAB	interacts with	PubMed
14-3-3 protein epsilon	YWHAE	interacts with	PubMed
14-3-3 protein gamma	YWHAG	interacts with	PubMed
14-3-3 protein zeta/delta	YWHAZ	interacts with	PubMed
transcriptional repressor protein YY1	YY1	binds	PubMed
alpha-2-macroglobulin isoform a precursor	A2M	cleaves	PubMed
actin, alpha skeletal muscle	ACTA1	cleaves	PubMed
	ACTA1	cleaves	PubMed
actin, aortic smooth muscle isoform 1	ACTA2	cleaves	PubMed
	ACTA2	cleaves	PubMed
	ACTB	cleaves	PubMed
	ACTB	cleaves	PubMed
actin, alpha cardiac muscle 1 isoform 1	ACTC1	cleaves	PubMed
	ACTC1	cleaves	PubMed
actin, cytoplasmic 2	ACTG1	cleaves	PubMed
	ACTG1	cleaves	PubMed
actin, gamma-enteric smooth muscle isoform 1 precursor	ACTG2	cleaves	PubMed
	ACTG2	cleaves	PubMed
alpha-actinin-1 isoform b	ACTN1	cleaves	PubMed
adenosylhomocysteinase isoform 1	AHCY	interacts with	PubMed
A-kinase anchor protein 8	AKAP8	cleaves	PubMed
A-kinase anchor protein 9 isoform 2	AKAP9	interacts with	PubMed
A-kinase-interacting protein 1 isoform a	AKIP1	interacts with	PubMed
fructose-bisphosphate aldolase A isoform 1	ALDOA	cleaves	PubMed
centrosome-associated protein ALMS1 isoform 1	ALMS1	interacts with	PubMed
AMP deaminase 2 isoform 1	AMPD2	cleaves	PubMed
anaphase-promoting complex subunit 1	ANAPC1	interacts with	PubMed
	ANAPC2	interacts with	PubMed
acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1	ANP32E	cleaves	PubMed
amyloid-beta precursor protein isoform a precursor	APP	cleaves	PubMed
rho guanine nucleotide exchange factor 12 isoform 1	ARHGEF12	interacts with	PubMed
	ARRB2	interacts with	PubMed
	ATP5F1A	cleaves	PubMed
apoptosis regulator BAX isoform beta	BAX	interacts with	PubMed
	BAX	cleaves	PubMed
apoptosis regulator Bcl-2 isoform alpha	BCL2	interacts with	PubMed
	BCL2	cleaves	PubMed
	BCL2	downregulates	PubMed
protein bicaudal D homolog 2 isoform 2	BICD2	interacts with	PubMed
BH3-interacting domain death agonist isoform 1	BID	induces cleavage of	PubMed
protein BUD31 homolog	BUD31	cleaves	PubMed
ashwin isoform 1	C2orf49	cleaves	PubMed
carbonic anhydrase 12 isoform 1 precursor	CA12	cleaves	PubMed
calmodulin-1 isoform 2	CALM1	cleaves	PubMed
histone-arginine methyltransferase CARM1 isoform 1	CARM1	interacts with	PubMed
caspase-3 isoform a preproprotein	CASP3	cleaves	PubMed
	CASP3	activates	PubMed
caspase-8 isoform 1 precursor	CASP8	cleaves	PubMed
	CASP8	activates	PubMed
caspase-9 isoform alpha precursor	CASP9	activates	PubMed
coiled-coil and C2 domain-containing protein 1A isoform 1	CC2D1A	cleaves	PubMed
	CCAR2	interacts with	PubMed
coiled-coil domain-containing protein 43 isoform 1	CCDC43	cleaves	PubMed
C-C chemokine receptor type 10	CCR10	cleaves	PubMed
	CDC5L	cleaves	PubMed
	CIITA	cooperates with	PubMed
casein kinase II subunit alpha isoform a	CSNK2A1	phosphorylated by	PubMed
casein kinase II subunit alpha'	CSNK2A2	phosphorylated by	PubMed
casein kinase II subunit beta isoform 1	CSNK2B	phosphorylated by	PubMed
	CST3	inhibited by	PubMed
	CST3	interacts with	PubMed
transcriptional repressor CTCF isoform 1	CTCF	cleaves	PubMed
catenin beta-1 isoform 1	CTNNB1	cleaves	PubMed
cytochrome c	CYCS	interacts with	PubMed
	CYCS	induces release of	PubMed
	DDX17	cleaves	PubMed
ATP-dependent RNA helicase DDX18	DDX18	cleaves	PubMed
	DDX5	cleaves	PubMed
desmin isoform 1	DES	cleaves	PubMed
DNA fragmentation factor subunit alpha isoform 1	DFFA	induces cleavage of	PubMed
DNA fragmentation factor subunit beta isoform 2	DFFB	induces cleavage of	PubMed
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 1	DHX16	cleaves	PubMed
protein diaphanous homolog 1 isoform 1	DIAPH1	cleaves	PubMed
	DIAPH1	interacts with	PubMed
dihydrolipoyl dehydrogenase, mitochondrial isoform 1 precursor	DLD	cleaves	PubMed
dnaJ homolog subfamily C member 7 isoform 1	DNAJC7	cleaves	PubMed
dnaJ homolog subfamily C member 8	DNAJC8	cleaves	PubMed
deoxyhypusine hydroxylase	DOHH	interacts with	PubMed
docking protein 1 isoform a	DOK1	interacts with	PubMed
deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 2	DUT	cleaves	PubMed
probable rRNA-processing protein EBP2 isoform 2	EBNA1BP2	cleaves	PubMed
eukaryotic translation elongation factor 1 epsilon-1 isoform 1	EEF1E1	cleaves	PubMed
	EEF1G	cleaves	PubMed
elongation factor 2	EEF2	cleaves	PubMed
	EIF2AK4	cleaves	PubMed
	EIF2AK4	cleaves	PubMed
	EIF3A	interacts with	PubMed
	EIF3B	interacts with	PubMed
	EIF3C	interacts with	PubMed
	EIF3D	cleaves	PubMed
	EIF3D	cleaves	PubMed
	EIF3D	interacts with	PubMed
	EIF3E	interacts with	PubMed
	EIF3F	interacts with	PubMed
	EIF3H	interacts with	PubMed
	EIF3K	interacts with	PubMed
	EIF3L	interacts with	PubMed
eukaryotic translation initiation factor 3 subunit M isoform 1	EIF3M	interacts with	PubMed
eukaryotic initiation factor 4A-II	EIF4A2	cleaves	PubMed
eukaryotic translation initiation factor 4 gamma 1 isoform 5	EIF4G1	cleaves	PubMed
eukaryotic translation initiation factor 5A-1 isoform B	EIF5A	cleaves	PubMed
echinoderm microtubule-associated protein-like 3 isoform 3	EML3	interacts with	PubMed
	ENO1	cleaves	PubMed
epiplakin	EPPK1	interacts with	PubMed
S-formylglutathione hydrolase	ESD	cleaves	PubMed
peptidyl-prolyl cis-trans isomerase FKBP4	FKBP4	cleaves	PubMed
	FKBP4	interacts with	PubMed
FAD synthase isoform 1	FLAD1	interacts with	PubMed
folliculin isoform 1	FLCN	interacts with	PubMed
	FLNA	cleaves	PubMed
filamin-B isoform 2	FLNB	cleaves	PubMed
filamin-C isoform a	FLNC	cleaves	PubMed
fibronectin isoform 1 precursor	FN1	cleaves	PubMed
folliculin-interacting protein 1 isoform 1	FNIP1	interacts with	PubMed
forkhead box protein C1	FOXC1	interacts with	PubMed
cyclin-G-associated kinase isoform 1	GAK	interacts with	PubMed
glial fibrillary acidic protein isoform 1	GFAP	cleaves	PubMed
GDP-L-fucose synthase isoform 2	GFUS	cleaves	PubMed
glutaredoxin 2 isoform 1	GLRX2	activated by	PubMed
glutaredoxin-related protein 5, mitochondrial precursor	GLRX5	activated by	PubMed
guanine nucleotide-binding protein-like 3 isoform 1	GNL3	cleaves	PubMed
golgin subfamily A member 1	GOLGA1	interacts with	PubMed
probable G-protein coupled receptor 25	GPR25	cleaves	PubMed
glutathione reductase, mitochondrial isoform 1 precursor	GSR	cleaves	PubMed
E3 ubiquitin-protein ligase HERC2	HERC2	interacts with	PubMed
protein HGH1 homolog	HGH1	interacts with	PubMed
	HNRNPA1	cleaves	PubMed
	HNRNPA2B1	cleaves	PubMed
heterogeneous nuclear ribonucleoprotein L isoform a	HNRNPL	cleaves	PubMed
	HNRNPU	cleaves	PubMed
	HSP90AA1	cleaves	PubMed
	HSP90AB1	cleaves	PubMed
	HSPD1	cleaves	PubMed
	HUWE1	cleaves	PubMed
intraflagellar transport protein 122 homolog isoform 3	IFT122	interacts with	PubMed
	IL1B	cleaves	PubMed
integrin alpha-3 preproprotein	ITGA3	cleaves	PubMed
integrin beta-4 isoform 1 precursor	ITGB4	cleaves	PubMed
	KARS1	inhibited by	PubMed
potassium channel subfamily K member 6	KCNK6	cleaves	PubMed
BTB/POZ domain-containing protein KCTD7 isoform 1	KCTD7	cleaves	PubMed
	KRR1	cleaves	PubMed
plastin-2	LCP1	cleaves	PubMed
leucine-rich repeat-containing G-protein coupled receptor 6 isoform 2	LGR6	cleaves	PubMed
	LIMD1	interacts with	PubMed
microtubule-associated protein 1A isoform 1	MAP1A	cleaves	PubMed
microtubule-associated proteins 1A/1B light chain 3A isoform a	MAP1LC3A	cleaves	PubMed
microtubule-associated proteins 1A/1B light chain 3B	MAP1LC3B	cleaves	PubMed
microtubule-associated proteins 1A/1B light chain 3C	MAP1LC3C	cleaves	PubMed
microtubule-associated protein 2 isoform 1	MAP2	cleaves	PubMed
induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1	MCL1	interacts with	PubMed
DNA replication licensing factor MCM5	MCM5	cleaves	PubMed
malate dehydrogenase, mitochondrial isoform 1 precursor	MDH2	cleaves	PubMed
DNA mismatch repair protein Msh2 isoform 1	MSH2	interacts with	PubMed
protein LYRIC isoform 1	MTDH	cleaved by	PubMed
myosin-10 isoform 2	MYH10	cleaves	PubMed
myosin-11 isoform SM1A	MYH11	cleaves	PubMed
myosin-13	MYH13	cleaves	PubMed
myosin-14 isoform 2	MYH14	cleaves	PubMed
myosin-6	MYH6	cleaves	PubMed
myosin-7	MYH7	cleaves	PubMed
myosin-9	MYH9	cleaves	PubMed
nuclear prelamin A recognition factor isoform a	NARF	interacts with	PubMed
nuclear autoantigenic sperm protein isoform 2	NASP	cleaves	PubMed
protein NDRG1 isoform 1	NDRG1	cleaves	PubMed
nuclear factor of activated T-cells 5 isoform c	NFAT5	interacts with	PubMed
nuclear factor NF-kappa-B p105 subunit isoform 1	NFKB1	cleaves	PubMed
	NFU1	interacts with	PubMed
nuclear transcription factor Y subunit alpha isoform 1	NFYA	cleaves	PubMed
H/ACA ribonucleoprotein complex subunit 2 isoform a	NHP2	cleaves	PubMed
MKI67 FHA domain-interacting nucleolar phosphoprotein	NIFK	cleaves	PubMed
	NKRF	cleaves	PubMed
	NONO	cleaves	PubMed
puromycin-sensitive aminopeptidase isoform 1	NPEPPS	cleaves	PubMed
nuclear mitotic apparatus protein 1 isoform 1	NUMA1	cleaves	PubMed
	OSBPL3	interacts with	PubMed
oxysterol-binding protein-related protein 6 isoform a	OSBPL6	interacts with	PubMed
deubiquitinase OTUD6B isoform 1	OTUD6B	cleaves	PubMed
proliferation-associated protein 2G4	PA2G4	cleaves	PubMed
	PABPC1	cleaves	PubMed
	PABPC1	cleaves	PubMed
polyadenylate-binding protein 3	PABPC3	cleaves	PubMed
	PABPC4	cleaves	PubMed
polyadenylate-binding protein 5	PABPC5	cleaves	PubMed
	PARP1	cleaves	PubMed
	PARP1	cleaves	PubMed
	PARP1	induces cleavage of	PubMed
protein mono-ADP-ribosyltransferase PARP4	PARP4	interacts with	PubMed
	PARP4	cleaves	PubMed
	PARP4	induces cleavage of	PubMed
protocadherin gamma-A6 isoform 1 precursor	PCDHGA6	cleaves	PubMed
protein disulfide-isomerase A3 precursor	PDIA3	cleaves	PubMed
phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform 1	PHKA1	cleaves	PubMed
phosphorylase b kinase regulatory subunit alpha, liver isoform	PHKA2	cleaves	PubMed
phosphorylase b kinase regulatory subunit beta isoform a	PHKB	cleaves	PubMed
elafin preproprotein	PI3	inhibited by	PubMed
	PKM	cleaves	PubMed
plastin-1	PLS1	cleaves	PubMed
	PLS3	cleaves	PubMed
phosphomannomutase 2	PMM2	cleaves	PubMed
DNA polymerase epsilon catalytic subunit A	POLE	interacts with	PubMed
DNA polymerase epsilon subunit 3	POLE3	interacts with	PubMed
DNA polymerase epsilon subunit 4	POLE4	interacts with	PubMed
POTE ankyrin domain family member F	POTEF	cleaves	PubMed
platelet basic protein preproprotein	PPBP	cleaves	PubMed
	PPIA	cleaves	PubMed
peptidyl-prolyl cis-trans isomerase H isoform 1	PPIH	cleaves	PubMed
peroxiredoxin-1	PRDX1	cleaves	PubMed
peroxiredoxin-2	PRDX2	cleaves	PubMed
protein kinase C alpha type	PRKCA	inhibited by	PubMed
protein kinase C beta type isoform 2	PRKCB	inhibited by	PubMed
protein kinase C delta type isoform c	PRKCD	inhibited by	PubMed
protein kinase C epsilon type	PRKCE	inhibited by	PubMed
protein kinase C gamma type isoform 2	PRKCG	inhibited by	PubMed
protein kinase C eta type	PRKCH	inhibited by	PubMed
protein kinase C iota type	PRKCI	inhibited by	PubMed
protein kinase C theta type isoform 1	PRKCQ	inhibited by	PubMed
protein kinase C zeta type isoform 1	PRKCZ	inhibited by	PubMed
serine/threonine-protein kinase PRP4 homolog	PRP4K	cleaves	PubMed
	PSIP1	cleaves	PubMed
	PSMA6	cleaves	PubMed
proteasome subunit beta type-9 precursor	PSMB9	cleaves	PubMed
	PSMC4	cleaves	PubMed
polypyrimidine tract-binding protein 1 isoform a	PTBP1	cleaves	PubMed
pumilio homolog 2 isoform 1	PUM2	interacts with	PubMed
KH domain-containing RNA-binding protein QKI isoform 1	QKI	cleaves	PubMed
RNA-binding protein 28 isoform 1	RBM28	cleaves	PubMed
RNA-binding protein 8A	RBM8A	cleaves	PubMed
regulator of chromosome condensation isoform c	RCC1	cleaves	PubMed
protein RCC2	RCC2	cleaves	PubMed
antiviral innate immune response receptor RIG-I isoform 1	RIGI	relocalizes	PubMed
receptor-interacting serine/threonine-protein kinase 1 isoform 2	RIPK1	disrupts	PubMed
	RIPK1	cleaves	PubMed
	RIPK1	cleaves	PubMed
	RIPK1	binds	PubMed
receptor-interacting serine/threonine-protein kinase 2 isoform 1	RIPK2	cleaves	PubMed
	RIPK2	binds	PubMed
ribonuclease inhibitor	RNH1	cleaves	PubMed
	RPL10	cleaves	PubMed
large ribosomal subunit protein eL20	RPL18A	cleaves	PubMed
	RPL23	cleaves	PubMed
	RPL3	cleaves	PubMed
large ribosomal subunit protein eL30	RPL30	cleaves	PubMed
large ribosomal subunit protein uL29	RPL35	cleaves	PubMed
	RPL5	cleaves	PubMed
	RPL6	cleaves	PubMed
	RPL7	cleaves	PubMed
	RPL9	cleaves	PubMed
small ribosomal subunit protein eS17	RPS17	cleaves	PubMed
small ribosomal subunit protein eS19 isoform 1	RPS19	cleaves	PubMed
small ribosomal subunit protein uS12	RPS23	cleaves	PubMed
small ribosomal subunit protein eS24 isoform c	RPS24	cleaves	PubMed
small ribosomal subunit protein eS1 isoform 1	RPS3A	cleaves	PubMed
small ribosomal subunit protein eS7	RPS7	cleaves	PubMed
ribosome biogenesis regulatory protein homolog	RRS1	cleaves	PubMed
serine--tRNA ligase, cytoplasmic isoform a	SARS1	interacts with	PubMed
	SART1	cleaves	PubMed
plasma protease C1 inhibitor precursor	SERPING1	cleaves	PubMed
splicing factor 3A subunit 3 isoform 1	SF3A3	interacts with	PubMed
	SF3B2	cleaves	PubMed
ADP/ATP translocase 1	SLC25A4	cleaves	PubMed
antileukoproteinase precursor	SLPI	enhanced by	PubMed
	SLPI	inhibited by	PubMed
probable global transcription activator SNF2L2 isoform a	SMARCA2	cleaves	PubMed
telomerase-binding protein EST1A isoform 1	SMG6	interacts with	PubMed
staphylococcal nuclease domain-containing protein 1	SND1	cleaves	PubMed
SNW domain-containing protein 1 isoform 2	SNW1	cleaves	PubMed
spindlin-2A	SPIN2A	cleaves	PubMed
spectrin alpha chain, erythrocytic 1	SPTA1	cleaves	PubMed
	SPTA1	cleaves	PubMed
	SPTAN1	cleaves	PubMed
spectrin beta chain, erythrocytic isoform b	SPTB	cleaves	PubMed
spectrin beta chain, non-erythrocytic 1 isoform 1	SPTBN1	cleaves	PubMed
spectrin beta chain, non-erythrocytic 2	SPTBN2	cleaves	PubMed
spectrin beta chain, non-erythrocytic 4 isoform sigma1	SPTBN4	cleaves	PubMed
spectrin beta chain, non-erythrocytic 5	SPTBN5	cleaves	PubMed
	SRP72	cleaves	PubMed
serine/arginine repetitive matrix protein 1 isoform 2	SRRM1	cleaves	PubMed
lupus La protein	SSB	cleaves	PubMed
serine/threonine-protein kinase 38	STK38	cleaves	PubMed
serine/threonine-protein kinase 38-like	STK38L	cleaves	PubMed
switch-associated protein 70 isoform 1	SWAP70	cleaves	PubMed
	THRAP3	cleaves	PubMed
mitochondrial import inner membrane translocase subunit Tim10	TIMM10	cleaves	PubMed
transketolase isoform 1	TKT	cleaves	PubMed
talin-1	TLN1	cleaves	PubMed
talin-2	TLN2	cleaves	PubMed
troponin C, slow skeletal and cardiac muscles	TNNC1	cleaves	PubMed
troponin C, skeletal muscle	TNNC2	cleaves	PubMed
mitochondrial import receptor subunit TOM22 homolog	TOMM22	interacts with	PubMed
	TOMM22	cleaves	PubMed
tropomyosin alpha-1 chain isoform Tpm1.5cy	TPM1	degrades	PubMed
	TPM1	cleaves	PubMed
tropomyosin beta chain isoform Tpm2.2st	TPM2	degrades	PubMed
tropomyosin alpha-3 chain isoform Tpm3.12st	TPM3	degrades	PubMed
zinc finger transcription factor Trps1 isoform 1	TRPS1	interacts with	PubMed
	TUBA1B	cleaves	PubMed
elongation factor Tu, mitochondrial isoform 1 precursor	TUFM	cleaves	PubMed
	UPF1	cleaves	PubMed
	VBP1	interacts with	PubMed
non-selective voltage-gated ion channel VDAC1 isoform 1	VDAC1	cleaves	PubMed
	VDAC1	interacts with	PubMed
	VIM	cleaves	PubMed
	VIM	cleaves	PubMed
	VIM	cleaves	PubMed
	VIM	degrades	PubMed
	VIM	cleaves	PubMed
actin nucleation-promoting factor WAS	WAS	cleaves	PubMed
	YWHAE	cleaves	PubMed
	YY1	cleaves	PubMed
zinc finger CCCH-type antiviral protein 1 isoform 1	ZC3HAV1	cleaves	PubMed
CAAX prenyl protease 1 homolog	ZMPSTE24	interacts with	PubMed
zinc finger protein 202 isoform 1	ZNF202	cleaves	PubMed
zinc finger protein 292 isoform 1	ZNF292	cleaves	PubMed
E3 ubiquitin-protein ligase ZNF598 isoform 1	ZNF598	cleaves	PubMed
protein ZNRD2 isoform 1	ZNRD2	interacts with	PubMed
	ACTA1	interacts with	PubMed
	ACTA1	co-localizes with	PubMed
	ACTA2	interacts with	PubMed
	ACTA2	co-localizes with	PubMed
	ACTB	co-localizes with	PubMed
	ACTB	binds	PubMed
	ACTC1	interacts with	PubMed
	ACTC1	co-localizes with	PubMed
	ACTG1	interacts with	PubMed
	ACTG1	co-localizes with	PubMed
	ACTG2	interacts with	PubMed
	ACTG2	co-localizes with	PubMed
double-stranded RNA-specific adenosine deaminase isoform a	ADAR	inhibited by	PubMed
A-kinase anchor protein 1, mitochondrial precursor	AKAP1	binds	PubMed
	AKAP8L	associates with	PubMed
	APOBEC3F	inhibited by	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	inhibited by	PubMed
	APOBEC3G	inhibited by	PubMed
	APOBEC3G	inhibited by	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	activates	PubMed
	APOBEC3G	interacts with	PubMed
	ATG16L1	interacts with	PubMed
	ATG16L2	interacts with	PubMed
caveolin-1 isoform alpha	CAV1	inhibited by	PubMed
cyclin-T1 isoform b	CCNT1	inhibited by	PubMed
cyclin-dependent kinase inhibitor 2A isoform p16INK4a	CDKN2A	inhibited by	PubMed
cyclic GMP-AMP synthase isoform 1	CGAS	cooperates with	PubMed
	CLTA	incorporates	PubMed
	CLTB	incorporates	PubMed
	CLTC	incorporates	PubMed
cleavage and polyadenylation specificity factor subunit 6 isoform 1	CPSF6	inhibited by	PubMed
granulocyte-macrophage colony-stimulating factor precursor	CSF2	interacts with	PubMed
	CSNK2A1	phosphorylated by	PubMed
	CSNK2A1	stimulated by	PubMed
	CSNK2A2	phosphorylated by	PubMed
	CSNK2A2	stimulated by	PubMed
	CSNK2B	phosphorylated by	PubMed
	CSNK2B	stimulated by	PubMed
	CXCL8	interacts with	PubMed
	DHX9	regulated by	PubMed
cytoplasmic dynein 1 heavy chain 1	DYNC1H1	regulated by	PubMed
cytoplasmic dynein 2 heavy chain 1 isoform 1	DYNC2H1	regulated by	PubMed
	DYNLL1	interacts with	PubMed
	DYNLL1	interacts with	PubMed
	ELAVL1	interacts with	PubMed
	ELAVL1	interacts with	PubMed
	ELAVL1	interacts with	PubMed
fragile X messenger ribonucleoprotein 1 isoform ISO1	FMR1	associates with	PubMed
	GEMIN2	stimulated by	PubMed
	GRB2	interacts with	PubMed
hepatitis A virus cellular receptor 1 isoform a precursor	HAVCR1	inhibited by	PubMed
hepatitis A virus cellular receptor 2 precursor	HAVCR2	inhibited by	PubMed
	HAVCR2	inhibited by	PubMed
histone deacetylase 4 isoform 2	HDAC4	regulated by	PubMed
	HDGFL2	interacts with	PubMed
	HSPD1	interacts with	PubMed
intercellular adhesion molecule 1 precursor	ICAM1	interacts with	PubMed
interferon alpha-1/13 precursor	IFNA1	inhibited by	PubMed
	IFNA1	inhibited by	PubMed
interferon alpha-10 precursor	IFNA10	inhibited by	PubMed
	IFNA10	inhibited by	PubMed
	IFNA13	inhibited by	PubMed
	IFNA13	inhibited by	PubMed
interferon alpha-14 precursor	IFNA14	inhibited by	PubMed
	IFNA14	inhibited by	PubMed
interferon alpha-16 precursor	IFNA16	inhibited by	PubMed
	IFNA16	inhibited by	PubMed
interferon alpha-17 precursor	IFNA17	inhibited by	PubMed
	IFNA17	inhibited by	PubMed
interferon alpha-2 precursor	IFNA2	inhibited by	PubMed
	IFNA2	inhibited by	PubMed
interferon alpha-21 precursor	IFNA21	inhibited by	PubMed
	IFNA21	inhibited by	PubMed
interferon alpha-4 precursor	IFNA4	inhibited by	PubMed
	IFNA4	inhibited by	PubMed
interferon alpha-5 precursor	IFNA5	inhibited by	PubMed
	IFNA5	inhibited by	PubMed
interferon alpha-6 precursor	IFNA6	inhibited by	PubMed
	IFNA6	inhibited by	PubMed
interferon alpha-7 precursor	IFNA7	inhibited by	PubMed
	IFNA7	inhibited by	PubMed
interferon alpha-8 precursor	IFNA8	inhibited by	PubMed
	IFNA8	inhibited by	PubMed
interferon beta precursor	IFNB1	upregulates	PubMed
interferon gamma precursor	IFNG	degraded by	PubMed
	IL10	inhibited by	PubMed
interleukin-12 subunit alpha isoform 1 precursor	IL12A	downregulated by	PubMed
interleukin-12 subunit beta precursor	IL12B	downregulated by	PubMed
interleukin-13 isoform 1 precursor	IL13	inhibited by	PubMed
	IL1B	interacts with	PubMed
	IPO7	interacts with	PubMed
	IPO7	imported by	PubMed
interferon regulatory factor 3 isoform 1	IRF3	activates	PubMed
	KARS1	interacts with	PubMed
lactoperoxidase isoform 1 preproprotein	LPO	inhibited by	PubMed
lactotransferrin isoform 1 preproprotein	LTF	inhibited by	PubMed
dual specificity mitogen-activated protein kinase kinase 1 isoform 1	MAP2K1	interacts with	PubMed
	MAPK1	interacts with	PubMed
mitogen-activated protein kinase 12 isoform 1	MAPK12	interacts with	PubMed
mitogen-activated protein kinase 3 isoform 1	MAPK3	interacts with	PubMed
	NCL	fractionates with	PubMed
nuclear factor of activated T-cells, cytoplasmic 1 isoform B	NFATC1	enhanced by	PubMed
nuclear factor of activated T-cells, cytoplasmic 2 isoform B	NFATC2	enhanced by	PubMed
Na(+)/H(+) exchange regulatory cofactor NHE-RF1	NHERF1	interacts with	PubMed
	NLRP3	interacts with	PubMed
nucleoside diphosphate kinase A isoform b	NME1	complexes with	PubMed
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 1	PIK3C2A	phosphorylated by	PubMed
	PPIA	enhanced by	PubMed
	PRKCA	phosphorylated by	PubMed
protein kinase C beta type isoform 1	PRKCB	phosphorylated by	PubMed
	PRKCD	phosphorylated by	PubMed
	PRKCE	phosphorylated by	PubMed
	PRKCG	phosphorylated by	PubMed
	PRKCH	phosphorylated by	PubMed
	PRKCI	phosphorylated by	PubMed
	PRKCQ	phosphorylated by	PubMed
	PRKCZ	phosphorylated by	PubMed
	PSMB8	degraded by	PubMed
protein-tyrosine kinase 2-beta isoform a	PTK2B	interacts with	PubMed
	PTK2B	interacts with	PubMed
ras-related protein Rab-11A isoform 1	RAB11A	interacts with	PubMed
ras-related protein Rab-7a	RAB7A	interacts with	PubMed
replication protein A 70 kDa DNA-binding subunit isoform 1	RPA1	inhibited by	PubMed
replication protein A 32 kDa subunit isoform 1	RPA2	inhibited by	PubMed
replication protein A 14 kDa subunit	RPA3	inhibited by	PubMed
replication protein A 30 kDa subunit	RPA4	inhibited by	PubMed
deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 1	SAMHD1	regulated by	PubMed
	SAMHD1	regulated by	PubMed
	SAMHD1	regulated by	PubMed
proto-oncogene tyrosine-protein kinase Src	SRC	interacts with	PubMed
syntaxin-binding protein 2 isoform a	STXBP2	regulated by	PubMed
trimethylguanosine synthase isoform 1	TGS1	enhances	PubMed
T-cell immunoglobulin and mucin domain-containing protein 4 isoform 1 precursor	TIMD4	inhibited by	PubMed
toll-like receptor 7 precursor	TLR7	inhibited by	PubMed
DNA topoisomerase 1	TOP1	enhanced by	PubMed
	TOP1	enhanced by	PubMed
DNA topoisomerase 2-alpha	TOP2A	co-localizes with	PubMed
DNA topoisomerase 2-beta isoform 2	TOP2B	co-localizes with	PubMed
	TP53	interacts with	PubMed
tumor susceptibility gene 101 protein	TSG101	inhibited by	PubMed
	EEF1A1	interacts with	PubMed
	EEF1A1	interacts with	PubMed
	EEF1G	interacts with	PubMed
	ICAM1	interacts with	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General protein information

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Preferred Names: Gag-Pol

Names: Gag-Pol polyprotein; aspartic peptidase; p66 subunit; integrase; Gag-Pol Transframe peptide; Pol; reverse transcriptase p51 subunit

NP_057849.4

Pr160

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001802.1 Reference assembly

Range

336..4642

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_057849.4 Gag-Pol [Human immunodeficiency virus 1]

See identical proteins and their annotated locations for NP_057849.4

Status: REVIEWED

UniProtKB/Swiss-Prot

O09777, P04585, P0C6F2, Q9WJC5

Conserved Domains (12) summary

smart00343
Location:391 → 406

ZnF_C2HC; zinc finger

cd01645
Location:605 → 821

RT_Rtv; RT_Rtv: Reverse transcriptases (RTs) from retroviruses (Rtvs). RTs catalyze the conversion of single-stranded RNA into double-stranded viral DNA for integration into host chromosomes. Proteins in this subfamily contain long terminal repeats (LTRs) and ...

pfam00540
Location:2 → 132

Gag_p17; gag gene protein p17 (matrix protein)

pfam00075
Location:1024 → 1144

RNase_H; RNase H

pfam00077
Location:495 → 586

RVP; Retroviral aspartyl protease

pfam00078
Location:650 → 821

RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)

pfam00552
Location:1368 → 1415

IN_DBD_C; Integrase DNA binding domain

pfam00607
Location:149 → 363

Gag_p24; gag gene protein p24 (core nucleocapsid protein)

pfam00665
Location:1205 → 1306

rve; Integrase core domain

pfam02022
Location:1155 → 1192

Integrase_Zn; Integrase Zinc binding domain

pfam06815
Location:905 → 1006

RVT_connect; Reverse transcriptase connection domain

pfam06817
Location:830 → 883

RVT_thumb; Reverse transcriptase thumb domain
NP_705926.1 aspartic peptidase

UniProtKB/TrEMBL

A0A1D8B9K4, C8AZH8, C8B397, C8B467, C8BBQ5, E9JDN4, O92103, O92139, Q5RZ08, Q5RZ09, Q72874, Q8Q3H0, Q903J0, Q9J2P7, Q9Q288, Q9Q2G8

Conserved Domains (1) summary

pfam00077
Location:7 → 98

RVP; Retroviral aspartyl protease
NP_705927.1 p66 subunit

UniProtKB/TrEMBL

H9BTT0, H9BTT1

Conserved Domains (4) summary

cd01645
Location:18 → 234

RT_Rtv; Reverse transcriptases (RTs) from retroviruses (Rtvs). RTs catalyze the conversion of single-stranded RNA into double-stranded viral DNA for integration into host chromosomes. Proteins in this subfamily contain long terminal repeats (LTRs) and are ...

pfam00075
Location:437 → 557

RNase_H; RNase H

pfam06815
Location:318 → 419

RVT_connect; Reverse transcriptase connection domain

pfam06817
Location:241 → 296

RVT_thumb; Reverse transcriptase thumb domain
NP_705928.1 integrase

UniProtKB/TrEMBL

A0A0U2T7G9, A0A0U2V1G2, A0A0U5B5J2, A0A3T0QI36, A0A8F3DM09

Conserved Domains (3) summary

pfam00552
Location:221 → 268

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:58 → 159

rve; Integrase core domain

pfam02022
Location:8 → 45

Integrase_Zn; Integrase Zinc binding domain
NP_787043.1 Gag-Pol Transframe peptide

UniProtKB/TrEMBL

A5YJG5, A5YJJ3
NP_789740.1 Pol

UniProtKB/TrEMBL

A0A6G6D3R8

Conserved Domains (9) summary

cd01645
Location:165 → 381

RT_Rtv; RT_Rtv: Reverse transcriptases (RTs) from retroviruses (Rtvs). RTs catalyze the conversion of single-stranded RNA into double-stranded viral DNA for integration into host chromosomes. Proteins in this subfamily contain long terminal repeats (LTRs) and ...

pfam00075
Location:584 → 704

RNase_H; RNase H

pfam00077
Location:55 → 146

RVP; Retroviral aspartyl protease

pfam00078
Location:210 → 381

RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)

pfam00552
Location:928 → 975

IN_DBD_C; Integrase DNA binding domain

pfam00665
Location:765 → 866

rve; Integrase core domain

pfam02022
Location:715 → 752

Integrase_Zn; Integrase Zinc binding domain

pfam06815
Location:465 → 566

RVT_connect; Reverse transcriptase connection domain

pfam06817
Location:390 → 443

RVT_thumb; Reverse transcriptase thumb domain
NP_789739.1 reverse transcriptase p51 subunit

Conserved Domains (3) summary

pfam06815
Location:318 → 419

RVT_connect; Reverse transcriptase connection domain

pfam06817
Location:241 → 296

RVT_thumb; Reverse transcriptase thumb domain

cl02808
Location:18 → 234

RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...