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TDRP testis development related protein [ Homo sapiens (human) ]

Gene ID: 157695, updated on 27-Nov-2024

Summary

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Official Symbol
TDRPprovided by HGNC
Official Full Name
testis development related proteinprovided by HGNC
Primary source
HGNC:HGNC:26951
See related
Ensembl:ENSG00000180190 MIM:619049; AllianceGenome:HGNC:26951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Inm01; TDRP1; TDRP2; C8orf42
Summary
Acts upstream of or within spermatogenesis. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta (RPKM 17.5), thyroid (RPKM 13.8) and 22 other tissues See more
Orthologs
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Genomic context

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See TDRP in Genome Data Viewer
Location:
8p23.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (489946..545780, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (249159..342875, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (439946..495780, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:328556-329056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26942 Neighboring gene family with sequence similarity 87 member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18878 Neighboring gene F-box protein 25 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429047-429548 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429549-430048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:436623-437436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:437437-438248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:452724-453298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:482877-483378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:486704-487214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:487215-487724 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:495813-496313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527413-527914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527915-528414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:563312-563864 Neighboring gene uncharacterized LOC124902055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:579043-579586 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:580473-581672 Neighboring gene glutamate rich 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:601645-602146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:602147-602646 Neighboring gene uncharacterized LOC124902053

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population. Kan M, et al. Diagn Pathol, 2014 Mar 25. PMID 24667176, Free PMC Article
  2. Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis. Wang X, et al. Biochem Biophys Res Commun, 2010 Mar 26. PMID 20170638
  3. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. Bielinski SJ, et al. Mayo Clin Proc, 2011 Jul. PMID 21646302, Free PMC Article
  4. Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes. Wang Y, et al. J Periodontol, 2020 Jun. PMID 31682009
  5. Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability. Ravichandran R, et al. EMBO Rep, 2019 Jul. PMID 31267705, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TDRP expression in healthy human palatal mucosa is strongly negatively correlated with serum cotinine levels
    Title: Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.
  2. Single nucleotide polymorphisms on genetic loci SOD2, MBP and C8orf42were not found significantly associated with advanced age-related macular degeneration in a Chinese cohort
    Title: Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. These current data demonstrated that as a nuclear factor, TDRP1 might play an important role in spermatogenesis.
    Title: Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44221, DKFZp686J15216

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion HTP PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis development-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256113.2 → NP_001243042.1  testis development-related protein isoform 2

    See identical proteins and their annotated locations for NP_001243042.1

    Status: VALIDATED

    Source sequence(s)
    AC083964, AC090135
    Consensus CDS
    CCDS59090.1
    UniProtKB/Swiss-Prot
    Q86YL5
    Related
    ENSP00000430325.1, ENST00000523656.5
    Conserved Domains (1) summary
    pfam15683
    Location:41 → 167
    TDRP; Testis development-related protein

  2. NM_001384899.1 → NP_001371828.1  testis development-related protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC083964, AC090135
    Consensus CDS
    CCDS47759.1
    UniProtKB/Swiss-Prot
    B6VF03, B9EG53, Q86YL5
    Related
    ENSP00000315111.6, ENST00000324079.11
    Conserved Domains (1) summary
    pfam15683
    Location:41 → 185
    TDRP; Testis development-related protein

  3. NM_175075.5 → NP_778250.2  testis development-related protein isoform 1

    See identical proteins and their annotated locations for NP_778250.2

    Status: VALIDATED

    Source sequence(s)
    AC083964, AC090135, AC090691
    Consensus CDS
    CCDS47759.1
    UniProtKB/Swiss-Prot
    B6VF03, B9EG53, Q86YL5
    Conserved Domains (1) summary
    pfam15683
    Location:41 → 185
    TDRP; Testis development-related protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    489946..545780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421392.1 → XP_047277348.1  testis development-related protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    249159..342875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359820.1 → XP_054215795.1  testis development-related protein isoform X7

  2. XM_054359818.1 → XP_054215793.1  testis development-related protein isoform X5

  3. XM_054359816.1 → XP_054215791.1  testis development-related protein isoform X3

  4. XM_054359814.1 → XP_054215789.1  testis development-related protein isoform X2

  5. XM_054359815.1 → XP_054215790.1  testis development-related protein isoform X2

  6. XM_054359817.1 → XP_054215792.1  testis development-related protein isoform X4

  7. XM_054359821.1 → XP_054215796.1  testis development-related protein isoform X8

  8. XM_054359819.1 → XP_054215794.1  testis development-related protein isoform X6

RNA

  1. XR_008487813.1 RNA Sequence

  2. XR_008487814.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001369716.1: Suppressed sequence

    Description
    NM_001369716.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86YL5.2 GenPept UniProtKB/Swiss-Prot:Q86YL5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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