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PRUNE2 prune homolog 2 with BCH domain [ Homo sapiens (human) ]

Gene ID: 158471, updated on 27-Nov-2024

Summary

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Official Symbol
PRUNE2provided by HGNC
Official Full Name
prune homolog 2 with BCH domainprovided by HGNC
Primary source
HGNC:HGNC:25209
See related
Ensembl:ENSG00000106772 MIM:610691; AllianceGenome:HGNC:25209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMCC1; BNIPXL; C9orf65; KIAA0367
Summary
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Broad expression in prostate (RPKM 10.8), brain (RPKM 9.0) and 20 other tissues See more
Orthologs
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Genomic context

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See PRUNE2 in Genome Data Viewer
Location:
9q21.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (76611376..76906114, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (88767783..89062562, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (79226292..79521030, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19963 Neighboring gene peptidylprolyl isomerase A pseudogene 87 Neighboring gene uncharacterized LOC105376095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:79284679-79285292 Neighboring gene NANOG hESC enhancer GRCh37_chr9:79303428-79303929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28482 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:79398353-79399552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79402243-79402744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79402745-79403244 Neighboring gene prostate cancer associated 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:79502679-79503275 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:79512967-79513466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:79571299-79571800 Neighboring gene LYPLA2 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79626622-79627122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79627123-79627623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79629105-79629618 Neighboring gene forkhead box B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene. Cardoso M, et al. Br J Cancer, 2023 Apr. PMID 36564567, Free PMC Article
  2. Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion. Yu W, et al. J Clin Endocrinol Metab, 2015 Feb. PMID 25387265
  3. Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues. Iwama E, et al. J Mol Neurosci, 2011 Jun. PMID 21234814
  4. Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells. Islam MS, et al. BMC Cancer, 2019 Jun 6. PMID 31170959, Free PMC Article
  5. [Expression of PRUNE2 mRNA and its positive correlation with non-coding RNA PCA3 in leiomyosarcoma]. Yang JL, et al. Zhonghua Zhong Liu Za Zhi, 2012 Jul. PMID 22967466

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene.
    Title: Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene.
  2. FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer.
    Title: FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer.
  3. The programmed expression of full-length BMCC1 in human neuroblastoma cells undergoing DNA damage-induced apoptosis.
    Title: Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells.
  4. E2F1 directly facilitated BMCC1 transcription. These results also suggest that BMCC1 induced by E2F1 acts as a tumor suppressor through its pro-apoptotic function, resulted in favorable prognosis of neuroblastoma.
    Title: Transcriptional regulation of BMCC1 mediated by E2F1 in neuroblastoma cells.
  5. Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer.
    Title: PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.
  6. BMCC1 negatively regulates phosphorylation pathway of AKT, resulted in apoptosis and the BNIP2 homology region of BMCC1 interacts with BCL2.
    Title: BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis.
  7. recurrent germ line and somatic mutations in PRUNE2 were found in parathyroid carcinoma and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found.
    Title: Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.
  8. BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.
    Title: BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.
  9. We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex.
    Title: Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.
  10. PRUNE2 expression is correlated with the survival of leiomyosarcoma patients. Non-coding RNA PCA3 has a significant positive correlation with PRUNE2 and may play an important role in the pathogenesis of leiomyosarcoma.
    Title: [Expression of PRUNE2 mRNA and its positive correlation with non-coding RNA PCA3 in leiomyosarcoma].
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ50060, FLJ54876, FLJ59118, KIAA0367, A214N16.3, bA214N16.3, DKFZp762K117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein prune homolog 2
Names
BCH motif-containing molecule at the carboxyl terminal region 1
BNIP2 motif containing molecule at the carboxyl terminal region 1
BNIP2 motif-containing molecule at the C-terminal region 1
olfaxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308047.2 → NP_001294976.1  protein prune homolog 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains one alternate in-frame exon and lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB002365, AB535152, AL359314, AL390239, BC019095, BC022571, CB146736, FJ808772
    Consensus CDS
    CCDS78407.1
    UniProtKB/TrEMBL
    A0A088AWP5, G8XWS8
    Related
    ENSP00000393843.3, ENST00000443509.6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2908
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2920 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  2. NM_001308048.2 → NP_001294977.1  protein prune homolog 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site, contains one alternate in-frame exon, and lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB050197, AB535152, AL359314, AL390239, BC019095, BC022571
    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  3. NM_001308049.2 → NP_001294978.1  protein prune homolog 2 isoform 4

    See identical proteins and their annotated locations for NP_001294978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks part of the 5' coding region, contains two alternate 5' exons, and uses an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB050197, AK296269, BC022571
    UniProtKB/TrEMBL
    B4DJW7, C9K0Q0
    Conserved Domains (2) summary
    pfam12496
    Location:48 → 164
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:166 → 287
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  4. NM_001308050.2 → NP_001294979.1  protein prune homolog 2 isoform 5

    See identical proteins and their annotated locations for NP_001294979.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks part of the 5' coding region, contains an alternate 5'-terminal exon, and uses an alternate start codon, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB050197, AK298805, BC022571
    UniProtKB/Swiss-Prot
    Q8WUY3
    Conserved Domains (2) summary
    pfam12496
    Location:63 → 179
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:181 → 302
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  5. NM_001308051.2 → NP_001294980.1  protein prune homolog 2 isoform 6

    See identical proteins and their annotated locations for NP_001294980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks part of the 5' and 3' coding region, contains an alternate 5'-terminal exon, and uses an alternate start codon and an alternate in-frame splice site, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB050197, AK299857, BC022571, DC342565
    UniProtKB/TrEMBL
    B4DSQ3, C9JCJ6
    Conserved Domains (2) summary
    pfam12496
    Location:63 → 180
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:182 → 303
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  6. NM_001330680.2 → NP_001317609.1  protein prune homolog 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL161626, AL359314
    Consensus CDS
    CCDS83375.1
    UniProtKB/TrEMBL
    Q5JUB8
    Related
    ENSP00000365907.2, ENST00000376717.6

  7. NM_015225.3 → NP_056040.2  protein prune homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_056040.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB050197, AL359314, AL390239, BC019095, BQ008420, DA410068
    Consensus CDS
    CCDS47982.1
    UniProtKB/Swiss-Prot
    B3KYC4, B4DQH8, O15073, Q58A63, Q5JUB6, Q5T304, Q5T476, Q6T2V6, Q6T2V7, Q8N665, Q8WUY3
    UniProtKB/TrEMBL
    G8XWS8
    Related
    ENSP00000365908.3, ENST00000376718.8
    Conserved Domains (3) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    cd00170
    Location:2899 → 3045
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:2799 → 2915
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

RNA

  1. NR_131751.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains one alternate exon and lacks several internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB002365, AB535152, AL359314, AL390239, BC019095, BC022571, FJ808772, FJ808773

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    76611376..76906114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422884.1 → XP_047278840.1  protein prune homolog 2 isoform X25

  2. XM_017014349.2 → XP_016869838.1  protein prune homolog 2 isoform X17

    UniProtKB/TrEMBL
    G8XWS8

  3. XM_017014352.2 → XP_016869841.1  protein prune homolog 2 isoform X21

    UniProtKB/TrEMBL
    G8XWS8

  4. XM_017014346.2 → XP_016869835.1  protein prune homolog 2 isoform X12

    UniProtKB/TrEMBL
    G8XWS8

  5. XM_006716986.2 → XP_006717049.1  protein prune homolog 2 isoform X5

    UniProtKB/TrEMBL
    G8XWS8
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2915
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2917 → 3038
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  6. XM_005251748.2 → XP_005251805.1  protein prune homolog 2 isoform X8

    UniProtKB/TrEMBL
    G8XWS8
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2908
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2920 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  7. XM_006716983.2 → XP_006717046.1  protein prune homolog 2 isoform X2

    UniProtKB/TrEMBL
    G8XWS8
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2908
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2920 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  8. XM_005251754.3 → XP_005251811.1  protein prune homolog 2 isoform X23

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2916
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2918 → 3039
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  9. XM_017014348.2 → XP_016869837.1  protein prune homolog 2 isoform X16

    UniProtKB/TrEMBL
    D6RTK6

  10. XM_011518323.3 → XP_011516625.1  protein prune homolog 2 isoform X9

    UniProtKB/TrEMBL
    D6RTK6
    Related
    ENSP00000397425.1, ENST00000428286.5
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2916
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2918 → 3039
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  11. XM_017014351.2 → XP_016869840.1  protein prune homolog 2 isoform X19

    UniProtKB/TrEMBL
    D6RTK6

  12. XM_005251750.2 → XP_005251807.1  protein prune homolog 2 isoform X10

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2916
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2918 → 3039
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  13. XM_006716985.2 → XP_006717048.1  protein prune homolog 2 isoform X3

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2916
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2918 → 3039
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  14. XM_047422883.1 → XP_047278839.1  protein prune homolog 2 isoform X24

  15. XM_011518327.2 → XP_011516629.1  protein prune homolog 2 isoform X14

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  16. XM_005251745.2 → XP_005251802.1  protein prune homolog 2 isoform X6

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  17. XM_005251751.2 → XP_005251808.1  protein prune homolog 2 isoform X18

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  18. XM_011518328.3 → XP_011516630.1  protein prune homolog 2 isoform X20

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  19. XM_005251746.2 → XP_005251803.1  protein prune homolog 2 isoform X7

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  20. XM_011518326.3 → XP_011516628.1  protein prune homolog 2 isoform X13

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  21. XM_006716982.2 → XP_006717045.1  protein prune homolog 2 isoform X1

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  22. XM_006716984.3 → XP_006717047.1  protein prune homolog 2 isoform X4

    UniProtKB/TrEMBL
    D6RTK6
    Conserved Domains (4) summary
    COG1227
    Location:24 → 278
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:221 → 315
    DHHA2; DHHA2 domain
    pfam12496
    Location:2799 → 2909
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2921 → 3042
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  23. XM_047422885.1 → XP_047278841.1  protein prune homolog 2 isoform X26

  24. XM_017014357.3 → XP_016869846.1  protein prune homolog 2 isoform X29

  25. XM_017014359.3 → XP_016869848.1  protein prune homolog 2 isoform X30

  26. XM_017014356.3 → XP_016869845.1  protein prune homolog 2 isoform X28

  27. XM_017014354.3 → XP_016869843.1  protein prune homolog 2 isoform X27

  28. XM_047422882.1 → XP_047278838.1  protein prune homolog 2 isoform X24

  29. XM_047422881.1 → XP_047278837.1  protein prune homolog 2 isoform X20

  30. XM_047422878.1 → XP_047278834.1  protein prune homolog 2 isoform X11

  31. XM_047422879.1 → XP_047278835.1  protein prune homolog 2 isoform X13

  32. XM_047422876.1 → XP_047278832.1  protein prune homolog 2 isoform X4

  33. XM_047422880.1 → XP_047278836.1  protein prune homolog 2 isoform X15

  34. XM_017014353.3 → XP_016869842.1  protein prune homolog 2 isoform X22

    UniProtKB/TrEMBL
    D6RTK6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    88767783..89062562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362198.1 → XP_054218173.1  protein prune homolog 2 isoform X25

  2. XM_054362188.1 → XP_054218163.1  protein prune homolog 2 isoform X17

  3. XM_054362193.1 → XP_054218168.1  protein prune homolog 2 isoform X21

  4. XM_054362183.1 → XP_054218158.1  protein prune homolog 2 isoform X12

  5. XM_054362176.1 → XP_054218151.1  protein prune homolog 2 isoform X5

  6. XM_054362179.1 → XP_054218154.1  protein prune homolog 2 isoform X8

  7. XM_054362172.1 → XP_054218147.1  protein prune homolog 2 isoform X2

  8. XM_054362195.1 → XP_054218170.1  protein prune homolog 2 isoform X23

  9. XM_054362187.1 → XP_054218162.1  protein prune homolog 2 isoform X16

  10. XM_054362180.1 → XP_054218155.1  protein prune homolog 2 isoform X9

  11. XM_054362190.1 → XP_054218165.1  protein prune homolog 2 isoform X19

  12. XM_054362181.1 → XP_054218156.1  protein prune homolog 2 isoform X10

  13. XM_054362173.1 → XP_054218148.1  protein prune homolog 2 isoform X3

  14. XM_054362197.1 → XP_054218172.1  protein prune homolog 2 isoform X24

  15. XM_054362186.1 → XP_054218161.1  protein prune homolog 2 isoform X14

  16. XM_054362177.1 → XP_054218152.1  protein prune homolog 2 isoform X6

  17. XM_054362189.1 → XP_054218164.1  protein prune homolog 2 isoform X18

  18. XM_054362192.1 → XP_054218167.1  protein prune homolog 2 isoform X20

  19. XM_054362178.1 → XP_054218153.1  protein prune homolog 2 isoform X7

  20. XM_054362185.1 → XP_054218160.1  protein prune homolog 2 isoform X13

  21. XM_054362171.1 → XP_054218146.1  protein prune homolog 2 isoform X1

  22. XM_054362175.1 → XP_054218150.1  protein prune homolog 2 isoform X4

  23. XM_054362199.1 → XP_054218174.1  protein prune homolog 2 isoform X26

  24. XM_054362202.1 → XP_054218177.1  protein prune homolog 2 isoform X29

  25. XM_054362203.1 → XP_054218178.1  protein prune homolog 2 isoform X30

  26. XM_054362201.1 → XP_054218176.1  protein prune homolog 2 isoform X28

  27. XM_054362200.1 → XP_054218175.1  protein prune homolog 2 isoform X27

  28. XM_054362196.1 → XP_054218171.1  protein prune homolog 2 isoform X24

  29. XM_054362191.1 → XP_054218166.1  protein prune homolog 2 isoform X20

  30. XM_054362182.1 → XP_054218157.1  protein prune homolog 2 isoform X11

  31. XM_054362184.1 → XP_054218159.1  protein prune homolog 2 isoform X13

  32. XM_054362174.1 → XP_054218149.1  protein prune homolog 2 isoform X4

  33. XM_054362194.1 → XP_054218169.1  protein prune homolog 2 isoform X22

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138818.2: Suppressed sequence

    Description
    NM_138818.2: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WUY3.3 GenPept UniProtKB/Swiss-Prot:Q8WUY3

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