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TCEAL6 transcription elongation factor A like 6 [ Homo sapiens (human) ]

Gene ID: 158931, updated on 27-Nov-2024

Summary

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Official Symbol
TCEAL6provided by HGNC
Official Full Name
transcription elongation factor A like 6provided by HGNC
Primary source
HGNC:HGNC:24553
See related
AllianceGenome:HGNC:24553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX2; Tceal3
Summary
Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in brain (RPKM 18.6), testis (RPKM 12.2) and 4 other tissues See more
Orthologs
all
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Genomic context

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See TCEAL6 in Genome Data Viewer
Location:
Xq22.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102138502..102142481, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (100583085..100587065, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101393474..101397453, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MT-ND6 pseudogene 13 Neighboring gene transcription elongation factor A like 2 Neighboring gene uncharacterized LOC105373299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29813 Neighboring gene brain expressed X-linked 5 Neighboring gene t-complex 11 family, X-linked 3, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression. Sui X, et al. Mol Med Rep, 2021 Sep. PMID 34278492, Free PMC Article
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
  3. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. Shamay M, et al. J Virol, 2012 May. PMID 22379092, Free PMC Article
  4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.
    Title: hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription elongation factor A protein-like 6
Names
TCEA-like protein 6
transcription elongation factor A (SII)-like 3
transcription elongation factor A (SII)-like 6
transcription elongation factor S-II protein-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006938.3 → NP_001006939.2  transcription elongation factor A protein-like 6 isoform 2

    See identical proteins and their annotated locations for NP_001006939.2

    Status: VALIDATED

    Source sequence(s)
    Z70719
    Conserved Domains (2) summary
    pfam04538
    Location:72 → 173
    BEX; Brain expressed X-linked like family
    pfam15724
    Location:27 → 94
    TMEM119; TMEM119 family

  2. NM_001367790.1 → NP_001354719.1  transcription elongation factor A protein-like 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    Z70719
    UniProtKB/Swiss-Prot
    Q5H9J8, Q6IPX3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    102138502..102142481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791816.1 Reference GRCh38.p14 PATCHES

    Range
    33591..37571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    100583085..100587065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IPX3.1 GenPept UniProtKB/Swiss-Prot:Q6IPX3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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