Icam5 intercellular adhesion molecule 5, telencephalin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Icam5provided by MGI
Official Full Name: intercellular adhesion molecule 5, telencephalinprovided by MGI
Primary source: MGI:MGI:109430
See related: Ensembl:ENSMUSG00000032174 AllianceGenome:MGI:109430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TLN; CD50; Tlcn; Icam3; ICAM-3; ICAM-5
Summary: Predicted to enable integrin binding activity. Involved in regulation of synapse assembly. Acts upstream of or within phagocytosis. Located in plasma membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in brain. Orthologous to human ICAM5 (intercellular adhesion molecule 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 62.6), cortex adult (RPKM 49.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.7 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20943372..20950331)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21032038..21039036)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome.
Title: ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb), follicle stimulating hormone beta (Fshb), and intracellular adhesion molecule-5 (Icam5) in females but only decreased expression of Icam5 in males.
Title: Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A.
This study revealed a similar expression of ICAM-5 in dendritic elements at P14 and P28; however, an increased prevalence of ICAM-5 was noted in dendritic protrusions at P28 in the MMP-9 null animals
Title: Subcellular localization of intercellular adhesion molecule-5 (telencephalin) in the visual cortex is not developmentally regulated in the absence of matrix metalloproteinase-9.
Results suggest that the interaction between ICAM-5 and beta1 integrins is important in formation of functional synapses.
Title: Interactions between ICAM-5 and β1 integrins regulate neuronal synapse formation.
MMPs and soluble ICAM-5 increase neuronal excitability
Title: MMPs and soluble ICAM-5 increase neuronal excitability within in vitro networks of hippocampal neurons.
the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin proteins and the formation of phagocytic cup-like structures on neuronal dendrites
Title: Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin.
analysis of activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and beta2 integrins
Title: Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.
Our results suggest that ICAM-5 plays a critical role in modulating chemokine production in the CNS.
Title: ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection.
Study defines a physiological mechanism for the proteolytic processing of ICAM-5 by MMP-2 and MMP-9 and the importance of the its cleavage on regulation of dendritic spine development.
Title: Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage.
A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting
Title: A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit160 (e-PCR), detects polymorphism
- UniSTS:131715

U06483 (e-PCR)
- UniSTS:125652

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: intercellular adhesion molecule 5

Names: intercellular adhesion molecule 3; telencephalin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410238.1 → NP_001397167.1 intercellular adhesion molecule 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC159314
NM_008319.3 → NP_032345.2 intercellular adhesion molecule 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_032345.2

Status: VALIDATED

Source sequence(s)

AC159314

Consensus CDS

CCDS22891.1

UniProtKB/Swiss-Prot

G5E826, Q2KHL7, Q3UY19, Q60625

Related

ENSMUSP00000019616.5, ENSMUST00000019616.6

Conserved Domains (6) summary

cd05755
Location:120 → 219

Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins

smart00408
Location:759 → 819

IGc2; Immunoglobulin C-2 Type

smart00410
Location:756 → 829

IG_like; Immunoglobulin like

pfam03921
Location:32 → 103

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

pfam07679
Location:572 → 659

I-set; Immunoglobulin I-set domain

cl11960
Location:687 → 742

Ig; Immunoglobulin domain