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SLC35G1 solute carrier family 35 member G1 [ Homo sapiens (human) ]

Gene ID: 159371, updated on 27-Nov-2024

Summary

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Official Symbol
SLC35G1provided by HGNC
Official Full Name
solute carrier family 35 member G1provided by HGNC
Primary source
HGNC:HGNC:26607
See related
Ensembl:ENSG00000176273 MIM:617167; AllianceGenome:HGNC:26607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POST; TMEM20; C10orf60
Summary
This gene encodes a transmembrane protein which is a member of the drug/metabolite transporter protein superfamily. The encoded protein may play a role in the regulation of calcium levels inside the cell. [provided by RefSeq, Sep 2016]
Expression
Biased expression in duodenum (RPKM 26.1), small intestine (RPKM 12.8) and 2 other tissues See more
Orthologs
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Genomic context

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See SLC35G1 in Genome Data Viewer
Location:
10q23.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93893978..93909830)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94773053..94788891)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95653735..95669587)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378437 Neighboring gene leucine rich glioma inactivated 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:95550082-95550640 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:95609025-95609669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2630 Neighboring gene RAB11A, member RAS oncogene family pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2631 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:95686691-95687890 Neighboring gene PIP5K1A and PSMD4 like (pseudogene) Neighboring gene uncharacterized LOC105378438

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption. Mimura Y, et al. Elife, 2024 Nov 7. PMID 39508819, Free PMC Article
  2. Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles. Hatzirodos N, et al. PLoS One, 2015. PMID 25775029, Free PMC Article
  3. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. Sherva R, et al. JAMA Psychiatry, 2016 May 1. PMID 27028160, Free PMC Article
  4. Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort. Wang J, et al. Biol Psychiatry, 2023 Nov 15. PMID 37393044
  5. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Krapivinsky G, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084111, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption.
    Title: SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption.
  2. Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort.
    Title: Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort.
  3. results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis.
    Title: Nuclear export of ubiquitinated proteins via the UBIN-POST system.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33990

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
solute carrier family 35 member G1
Names
partner of STIM1
transmembrane protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051626.1 RefSeqGene

    Range
    5009..14855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134658.3 → NP_001128130.1  solute carrier family 35 member G1 isoform 1

    See identical proteins and their annotated locations for NP_001128130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK091309, AL138923, BC041432, BC104814
    Consensus CDS
    CCDS44459.1
    UniProtKB/Swiss-Prot
    Q2M3R5, Q86YG5, Q8NBA5
    UniProtKB/TrEMBL
    B7ZKP1
    Related
    ENSP00000400932.1, ENST00000427197.2
    Conserved Domains (1) summary
    COG0697
    Location:70 → 359
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  2. NM_001345993.2 → NP_001332922.1  solute carrier family 35 member G1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL138923, BC143283, DA644843
    UniProtKB/TrEMBL
    B7ZKP0
    Conserved Domains (1) summary
    COG0697
    Location:53 → 342
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

  3. NM_153226.4 → NP_694958.1  solute carrier family 35 member G1 isoform 2

    See identical proteins and their annotated locations for NP_694958.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a protein (isoform 2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK091309, AL138923, BC041432
    Consensus CDS
    CCDS7432.1
    UniProtKB/TrEMBL
    B7ZKP1
    Related
    ENSP00000360462.3, ENST00000371408.7
    Conserved Domains (2) summary
    COG0697
    Location:69 → 358
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:68 → 201
    EamA; EamA-like transporter family

RNA

  1. NR_144335.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL138923, BC036382, DA644843
    Related
    ENST00000483386.5

  2. NR_144336.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK091309, AL138923, BC047102, BM677569, BU608007, R56424
    Related
    ENST00000603665.1

  3. NR_144337.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL138923

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    93893978..93909830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    94773053..94788891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2M3R5.1 GenPept UniProtKB/Swiss-Prot:Q2M3R5

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