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Igfbp4 insulin-like growth factor binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 16010, updated on 27-Nov-2024

Summary

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Official Symbol
Igfbp4provided by MGI
Official Full Name
insulin-like growth factor binding protein 4provided by MGI
Primary source
MGI:MGI:96439
See related
Ensembl:ENSMUSG00000017493 AllianceGenome:MGI:96439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Deb2; IBP-4; IGFBP-4
Summary
Enables insulin-like growth factor binding activity. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; early embryo; female reproductive system; limb; and lung. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver adult (RPKM 884.2), subcutaneous fat pad adult (RPKM 473.1) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Igfbp4 in Genome Data Viewer
Location:
11 D; 11 62.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98930820..98943481)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99040005..99052655)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30695 Neighboring gene gap junction protein, delta 3 Neighboring gene topoisomerase (DNA) II alpha Neighboring gene STARR-positive B cell enhancer ABC_E17 Neighboring gene predicted gene, 23451 Neighboring gene tensin 4 Neighboring gene STARR-positive B cell enhancer ABC_E377 Neighboring gene STARR-seq mESC enhancer starr_30701 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:99009129-99009367 Neighboring gene C-C motif chemokine receptor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots. Maridas DE, et al. Endocrinology, 2017 Oct 1. PMID 28938423, Free PMC Article
  2. Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy. Zhang M, et al. J Biol Chem, 2002 Jun 14. PMID 11923290
  3. Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice. Zhou R, et al. J Mol Endocrinol, 2004 Apr. PMID 15072544
  4. Characterization of the mouse insulin-like growth factor binding protein 4 gene regulatory region and expression studies. Glantschnig H, et al. DNA Cell Biol, 1998 Jan. PMID 9468222
  5. IGFBP-4 degradation by pregnancy-associated plasma protein-A in MC3T3 osteoblasts. Bunn RC, et al. Biochem Biophys Res Commun, 2004 Dec 17. PMID 15541345

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma.
    Title: Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma.
  2. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
    Title: The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
  3. Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
    Title: Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
  4. IGFBP-4 enhances VEGF-induced angiogenesis in a mouse model of myocardial infarction.
    Title: IGFBP-4 enhances VEGF-induced angiogenesis in a mouse model of myocardial infarction.
  5. Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence.
    Title: Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence.
  6. Igfbp4 is required for inguinal fat expansion in female mice but not in male mice. However, gonadal WAT expansion, which is prevented by estrogen during high-fat diet, does not require Igfbp4.
    Title: IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots.
  7. IGFBP-4 modulates the skeleton in a gender-specific manner, acting as both a cell autonomous and cell non-autonomous factor.
    Title: IGFBP-4 regulates adult skeletal growth in a sex-specific manner.
  8. exerts a negative effect on basal intestinal growth but plays a positive regulatory role in the intestinotropic actions of GLP-2
    Title: IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine.
  9. IGF-1/IGFbp4 signaling regulated the post-developmental adipose tissue expansion.
    Title: Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
  10. Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development.
    Title: Expression of insulin-like growth factor binding proteins during mouse cochlear development.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cell growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of glucose metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within type B pancreatic cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor-binding protein 4
Names
Band 3A
IGF-binding protein 4
differentially expressed in B16F10 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010517.4 → NP_034647.1  insulin-like growth factor-binding protein 4 precursor

    See identical proteins and their annotated locations for NP_034647.1

    Status: VALIDATED

    Source sequence(s)
    AI838737, AL591067
    Consensus CDS
    CCDS25371.1
    UniProtKB/Swiss-Prot
    O35666, P47879, Q3TMV0
    UniProtKB/TrEMBL
    Q8BSM9
    Related
    ENSMUSP00000017637.7, ENSMUST00000017637.13
    Conserved Domains (2) summary
    smart00121
    Location:25 → 101
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:170 → 245
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98930820..98943481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245599.2 → XP_030101459.1  insulin-like growth factor-binding protein 4 isoform X1

    UniProtKB/Swiss-Prot
    O35666, P47879, Q3TMV0
    UniProtKB/TrEMBL
    Q8BSM9
    Conserved Domains (2) summary
    smart00121
    Location:25 → 101
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:170 → 245
    Thyroglobulin_1; Thyroglobulin type-1 repeat

  2. XM_036156346.1 → XP_036012239.1  insulin-like growth factor-binding protein 4 isoform X1

    UniProtKB/Swiss-Prot
    O35666, P47879, Q3TMV0
    UniProtKB/TrEMBL
    Q8BSM9
    Conserved Domains (2) summary
    smart00121
    Location:25 → 101
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:170 → 245
    Thyroglobulin_1; Thyroglobulin type-1 repeat

  3. XM_030245598.1 → XP_030101458.1  insulin-like growth factor-binding protein 4 isoform X1

    UniProtKB/Swiss-Prot
    O35666, P47879, Q3TMV0
    UniProtKB/TrEMBL
    Q8BSM9
    Conserved Domains (2) summary
    smart00121
    Location:25 → 101
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:170 → 245
    Thyroglobulin_1; Thyroglobulin type-1 repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47879.2 GenPept UniProtKB/Swiss-Prot:P47879

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