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Il18bp interleukin 18 binding protein [ Mus musculus (house mouse) ]

Gene ID: 16068, updated on 4-Jan-2025

Summary

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Official Symbol
Il18bpprovided by MGI
Official Full Name
interleukin 18 binding proteinprovided by MGI
Primary source
MGI:MGI:1333800
See related
Ensembl:ENSMUSG00000070427 AllianceGenome:MGI:1333800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MC54L; Igifbp; IL-18BP
Summary
Predicted to enable interleukin-18 binding activity. Predicted to be involved in T-helper 1 type immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in gut; liver; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in allergic contact dermatitis and myocardial infarction. Orthologous to human IL18BP (interleukin 18 binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in thymus adult (RPKM 16.5), liver E18 (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Il18bp in Genome Data Viewer
Location:
7 E2; 7 54.71 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101664281..101669699, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102015074..102018232, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8193 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome. Harel M, et al. J Immunol, 2023 Jun 1. PMID 37074208, Free PMC Article
  2. Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome. Harel M, et al. J Immunol, 2020 Aug 15. PMID 32651219
  3. Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model. Li JM, et al. J Vasc Surg, 2008 May. PMID 18455646
  4. Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein. Banda NK, et al. J Immunol, 2003 Feb 15. PMID 12574381
  5. The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury. Gu H, et al. Transpl Int, 2015 Dec. PMID 26340315

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome.
    Title: IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome.
  2. Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome.
    Title: Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome.
  3. IL-18BP possessed protective effect against LPS-induced ALI, which might be associated with its regulation of NF-kappaB and Nrf2 activities.
    Title: Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
  4. asthma is very likely to be determined by balance of IL-18/IL-18BP/IL-18R expression in inflammatory cells.
    Title: Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.
  5. IL-18BP ameliorates cardiac ischemia/reperfusion injury in part through suppression of Th17 differentiation.
    Title: The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury.
  6. Data show that IL-18bp acts as a sensor for IFN-gamma and can regulate both Th1 and Th17 responses in the CNS.
    Title: Inflammation in the central nervous system and Th17 responses are inhibited by IFN-gamma-Induced IL-18 binding protein.
  7. IL-18 and IL-18BP may have roles in testicular development, and also in the regulation of testicular functions under physiological conditions
    Title: Constitutive expression of IL-18 binding protein in murine testicular tissues and cells.
  8. A single intravenous dose of recombinant mouse IL18BP decreased neointimal hyperplasia and improved arterial L/A ratios in an atherosclerotic balloon-injury animal model.
    Title: Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model.
  9. Administratioan of murine IL-18BP at the time of the booster injection of bovine CII reduces the progressive severity of collagen-induced arthritis; both clinical disease activity and histological scores are decreased by 50%.
    Title: Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.
  10. functional polarization of Ag-specific CD4(+) Th2 cells entering the CNS during the accelerating phase of experimental autoimmune encephalomyelitis is flexible and dependent on IL-18, which is overturned by IL-18 binding protein
    Title: Targeted overexpression of IL-18 binding protein at the central nervous system overrides flexibility in functional polarization of antigen-specific Th2 cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-18 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-18 binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-18 binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in T-helper 1 type immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in T-helper 1 type immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-18-binding protein
Names
interferon gamma-inducing factor-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363982.1 → NP_001350911.1  interleukin-18-binding protein precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240, AK003370
    Consensus CDS
    CCDS21522.1
    UniProtKB/Swiss-Prot
    Q4FJR8, Q4FK87, Q9CV30, Q9QUH2, Q9Z0M9, Q9Z0N0
    Related
    ENSMUSP00000091685.4, ENSMUST00000094134.5
    Conserved Domains (1) summary
    cl23951
    Location:47 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  2. NM_001382458.1 → NP_001369387.1  interleukin-18-binding protein precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    Q4FJR8, Q4FK87, Q9CV30, Q9QUH2, Q9Z0M9, Q9Z0N0
    Conserved Domains (1) summary
    cl23951
    Location:47 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  3. NM_010531.2 → NP_034661.1  interleukin-18-binding protein precursor

    See identical proteins and their annotated locations for NP_034661.1

    Status: VALIDATED

    Source sequence(s)
    AC167240, AF122907
    Consensus CDS
    CCDS21522.1
    UniProtKB/Swiss-Prot
    Q4FJR8, Q4FK87, Q9CV30, Q9QUH2, Q9Z0M9, Q9Z0N0
    Related
    ENSMUSP00000148080.2, ENSMUST00000209844.2
    Conserved Domains (1) summary
    cl23951
    Location:47 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101664281..101669699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242160.2 → XP_030098020.1  interleukin-18-binding protein isoform X2

    UniProtKB/Swiss-Prot
    Q4FJR8, Q4FK87, Q9CV30, Q9QUH2, Q9Z0M9, Q9Z0N0
    Conserved Domains (1) summary
    cl23951
    Location:47 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  2. XM_036152698.1 → XP_036008591.1  interleukin-18-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A1B0GT50
    Related
    ENSMUSP00000148201.2, ENSMUST00000209368.2
    Conserved Domains (1) summary
    cl23951
    Location:47 → 164
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0M9.2 GenPept UniProtKB/Swiss-Prot:Q9Z0M9

Gene LinkOut

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