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Il12rb2 interleukin 12 receptor, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 16162, updated on 27-Nov-2024

Summary

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Official Symbol
Il12rb2provided by MGI
Official Full Name
interleukin 12 receptor, beta 2provided by MGI
Primary source
MGI:MGI:1270861
See related
Ensembl:ENSMUSG00000018341 AllianceGenome:MGI:1270861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifnm; IL-12RB2; A930027I18Rik
Summary
Enables protein kinase binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation; response to cytokine; and response to lipopolysaccharide. Located in external side of plasma membrane. Is expressed in several structures, including brain ventricular layer; genitourinary system; incisor; olfactory epithelium; and submandibular gland. Orthologous to human IL12RB2 (interleukin 12 receptor subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 1.8), cerebellum adult (RPKM 1.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Il12rb2 in Genome Data Viewer
Location:
6 C1; 6 30.81 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67263914..67353277, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67285986..67376293, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16173 Neighboring gene predicted gene, 38825 Neighboring gene STARR-seq mESC enhancer starr_16175 Neighboring gene Sod1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16176 Neighboring gene STARR-seq mESC enhancer starr_16180 Neighboring gene STARR-positive B cell enhancer ABC_E2787 Neighboring gene STARR-seq mESC enhancer starr_16184 Neighboring gene serpine1 mRNA binding protein 1 Neighboring gene predicted gene, 57761 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase pseudogene Neighboring gene ribosomal protein S7 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. Wu C, et al. J Immunol, 2000 Dec 1. PMID 11086056
  2. IL-12Rbeta2-deficient mice of a genetically resistant background are susceptible to Leishmania major infection and develop a parasite-specific Th2 immune response. Chakir H, et al. Microbes Infect, 2003 Apr. PMID 12706437
  3. Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP. Niedbala W, et al. Proc Natl Acad Sci U S A, 2002 Dec 10. PMID 12451176, Free PMC Article
  4. Treatment of Brucella-susceptible mice with IL-12 increases primary and secondary immunity. Sathiyaseelan J, et al. Cell Immunol, 2006 Sep. PMID 17184756
  5. Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation. Regoli M, et al. Front Immunol, 2018. PMID 29896198, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation.
    Title: IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation.
  2. Autocrine TGF-beta1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rbeta2 Downregulation.
    Title: Autocrine TGF-β1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rβ2 Downregulation.
  3. Morphological and Functional Characterization of IL-12Rbeta2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation.
    Title: Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation.
  4. These results provide a new pathway of Th1 response regulation where IL-12 secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells.
    Title: Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.
  5. in neonatal mice, IL-12 uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 differentiation
    Title: Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn.
  6. survival of secondary LVS challenge was not strictly dependent on IL-12Rbeta2
    Title: IL-12Rβ2 is critical for survival of primary Francisella tularensis LVS infection.
  7. Data indicate that delayed induction of the IL-12Rbeta2 receptor component after STAT1 activation helped ensure that Treg cells do not readily complete STAT4-dependent Th1 cell development and lose their ability to suppress effector T cell proliferation.
    Title: T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2.
  8. Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
    Title: The composition and signaling of the IL-35 receptor are unconventional.
  9. IL-12R-beta2 signaling is essential for Plasmodium berghei ANKA-induced experimental cerebral malaria development
    Title: IL-12Rβ2 is essential for the development of experimental cerebral malaria.
  10. Data show that T(H)1 differentiation was impaired in Il2(-/-) T cells but was restored by IL-12Rbeta2 expression.
    Title: Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-12-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-12-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to cytokine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within type II interferon production IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-12 receptor subunit beta-2
Names
IL-12 receptor subunit beta-2
IL-12R subunit beta-2
interferon response to microorganisms

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311141.1 → NP_001298070.1  interleukin-12 receptor subunit beta-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore, differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130822, BC137745
    Consensus CDS
    CCDS80543.1
    UniProtKB/TrEMBL
    D3Z6H5
    Related
    ENSMUSP00000113267.2, ENSMUST00000117441.8
    Conserved Domains (2) summary
    cd00063
    Location:104 → 191
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:202 → 289
    fn3; Fibronectin type III domain

  2. NM_008354.4 → NP_032380.1  interleukin-12 receptor subunit beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC130822
    Consensus CDS
    CCDS20220.1
    UniProtKB/Swiss-Prot
    B9EHD9, P97378
    Related
    ENSMUSP00000010605.4, ENSMUST00000018485.4
    Conserved Domains (3) summary
    cd00063
    Location:240 → 332
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:438 → 523
    fn3; Fibronectin type III domain
    pfam06328
    Location:28 → 120
    Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    67263914..67353277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505617.5 → XP_006505680.1  interleukin-12 receptor subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006505680.1

    UniProtKB/Swiss-Prot
    B9EHD9, P97378
    Conserved Domains (3) summary
    cd00063
    Location:240 → 332
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:438 → 523
    fn3; Fibronectin type III domain
    pfam06328
    Location:28 → 120
    Lep_receptor_Ig; Ig-like C2-type domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97378.1 GenPept UniProtKB/Swiss-Prot:P97378

Gene LinkOut

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