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Itgax integrin alpha X [ Mus musculus (house mouse) ]

Gene ID: 16411, updated on 27-Nov-2024

Summary

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Official Symbol
Itgaxprovided by MGI
Official Full Name
integrin alpha Xprovided by MGI
Primary source
MGI:MGI:96609
See related
Ensembl:ENSMUSG00000030789 AllianceGenome:MGI:96609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cr4; N418; Cd11c
Summary
Predicted to enable integrin binding activity and receptor tyrosine kinase binding activity. Involved in positive regulation of gene expression and positive regulation of myelination. Acts upstream of or within defense response to virus. Located in external side of plasma membrane. Is expressed in heart and hemolymphoid system. Orthologous to human ITGAX (integrin subunit alpha X). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 12.4), lung adult (RPKM 9.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Itgax in Genome Data Viewer
Location:
7 F3; 7 69.98 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127728697..127749829)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128129526..128150657)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene integrin alpha M Neighboring gene STARR-seq mESC enhancer starr_20200 Neighboring gene STARR-positive B cell enhancer ABC_E8211 Neighboring gene predicted gene 45700 Neighboring gene mitochondrial carrier triple repeat 1 pseudogene Neighboring gene integrin, alpha D Neighboring gene predicted gene, 39091

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice. Ren YJ, et al. Int J Mol Med, 2017 Jun. PMID 28440501
  2. CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Packard RR, et al. Circ Res, 2008 Oct 24. PMID 18832748, Free PMC Article
  3. Targeted delivery of tumor antigens to activated dendritic cells via CD11c molecules induces potent antitumor immunity in mice. Wei H, et al. Clin Cancer Res, 2009 Jul 15. PMID 19584156
  4. Alveolar macrophages transport pathogens to lung draining lymph nodes. Kirby AC, et al. J Immunol, 2009 Aug 1. PMID 19620319, Free PMC Article
  5. CD11c(+) Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Sandor AM, et al. Front Immunol, 2019. PMID 30766536, Free PMC Article

See all (187) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Downregulation of ITGAX Exacerbates Amyloid-beta Plaque Deposition in Alzheimer's Disease by Increasing Polarization of M1 Microglia.
    Title: The Downregulation of ITGAX Exacerbates Amyloid-β Plaque Deposition in Alzheimer's Disease by Increasing Polarization of M1 Microglia.
  2. Integrin CD11c regulates B cell homeostasis.
    Title: Integrin CD11c regulates B cell homeostasis.
  3. Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
    Title: Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
  4. CD11c is not required by microglia to convey neuroprotection after prion infection.
    Title: CD11c is not required by microglia to convey neuroprotection after prion infection.
  5. CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
    Title: CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
  6. CD11c regulates neutrophil maturation.
    Title: CD11c regulates neutrophil maturation.
  7. PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-alpha Signaling Pathway.
    Title: PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-α Signaling Pathway.
  8. CD11c regulates late-stage T cell development in the thymus.
    Title: CD11c regulates late-stage T cell development in the thymus.
  9. Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils.
    Title: Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils.
  10. Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain.
    Title: Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain.
Submit: New GeneRIF Correction See all GeneRIFs (99)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT acts_upstream_of_or_within activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial tube morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myelination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin alphaX-beta2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integrin alpha-X
Names
CD11 antigen-like family member C
CD11C (p150) alpha polypeptide
complement receptor 4
integrin aX
leukocyte adhesion glycoprotein p150,95 alpha chain
leukocyte adhesion receptor p150,95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363984.1 → NP_001350913.1  integrin alpha-X isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124566
    UniProtKB/TrEMBL
    Q6PG66
    Conserved Domains (1) summary
    cl00057
    Location:151 → 291
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. NM_001363985.1 → NP_001350914.1  integrin alpha-X isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124566
    Consensus CDS
    CCDS90336.1
    UniProtKB/TrEMBL
    A0A0U1RNJ3, Q8C270
    Related
    ENSMUSP00000145587.2, ENSMUST00000205460.2
    Conserved Domains (1) summary
    cl00057
    Location:151 → 238
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. NM_021334.3 → NP_067309.1  integrin alpha-X isoform 1 precursor

    See identical proteins and their annotated locations for NP_067309.1

    Status: VALIDATED

    Source sequence(s)
    AC124566
    Consensus CDS
    CCDS40150.1
    UniProtKB/Swiss-Prot
    Q9QXH4
    UniProtKB/TrEMBL
    Q3TD13, Q3U1P9
    Related
    ENSMUSP00000033053.7, ENSMUST00000033053.8
    Conserved Domains (4) summary
    smart00191
    Location:518 → 573
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:151 → 326
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1138 → 1152
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:616 → 987
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127728697..127749829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_378219.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXH4.1 GenPept UniProtKB/Swiss-Prot:Q9QXH4

Gene LinkOut

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