Jak2 Janus kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 16452, updated on 27-Nov-2024

Summary

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Official Symbol: Jak2provided by MGI
Official Full Name: Janus kinase 2provided by MGI
Primary source: MGI:MGI:96629
See related: Ensembl:ENSMUSG00000024789 AllianceGenome:MGI:96629
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fd17
Summary: Enables interleukin-12 receptor binding activity and protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to dexamethasone stimulus; and regulation of apoptotic process. Located in caveola and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 6.6), CNS E18 (RPKM 6.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

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See Jak2 in Genome Data Viewer

Location:: 19 C1; 19 23.73 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (29229006..29290495)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (29251803..29313095)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Platelets and neutrophils cooperate to induce increased neutrophil extracellular trap formation in JAK2V617F myeloproliferative neoplasms.
Title: Platelets and neutrophils cooperate to induce increased neutrophil extracellular trap formation in JAK2V617F myeloproliferative neoplasms.
Loss of Dnmt3a increases self-renewal and resistance to pegIFN-alpha in JAK2-V617F-positive myeloproliferative neoplasms.
Title: Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2-V617F-positive myeloproliferative neoplasms.
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia.
Title: Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia.
Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms.
Title: Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms.
Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk.
Title: Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk.
miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway.
Title: miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway.
IL-1beta promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells.
Title: IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells.
Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms.
Title: Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms.
[IL-6 enhances the phagocytic function of mouse alveolar macrophages by activating the JAK2/STAT3 signaling pathway].
Title: [IL-6 enhances the phagocytic function of mouse alveolar macrophages by activating the JAK2/STAT3 signaling pathway].
Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice.
Title: Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (318)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (8) 1 citation
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Jak2 (e-PCR), detects polymorphism
- UniSTS:143639

Jak2 (e-PCR), detects polymorphism
- UniSTS:143640

Jak2 (e-PCR), detects polymorphism
- UniSTS:527397

AI504024 (e-PCR)
- UniSTS:186150

L16956 (e-PCR)
- UniSTS:160821

L16956 (e-PCR)
- UniSTS:181218

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor binding	IEA Inferred from Electronic Annotation more info
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables growth hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3Y41 kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	ISO Inferred from Sequence Orthology more info
enables interleukin-12 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables peptide hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables signaling receptor activator activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables type 1 angiotensin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 1 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of Janus kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-3	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in defense response to symbiont	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythropoietin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in growth hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-12-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-23-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-3-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-5-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear receptor-mediated mineralocorticoid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nuclear receptor-mediated mineralocorticoid signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MHC class II biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell proliferation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 type immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth hormone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-17 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of leukocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse to nucleus signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to amine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to antibiotic	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to granulocyte macrophage colony-stimulating factor	NAS Non-traceable Author Statement more info	PubMed
involved_in response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in response to hydroperoxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-12	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-12	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within symbiont-induced defense-related programmed cell death	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type II interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in euchromatin	IEA Inferred from Electronic Annotation more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of granulocyte macrophage colony-stimulating factor receptor complex	IEA Inferred from Electronic Annotation more info
part_of granulocyte macrophage colony-stimulating factor receptor complex	ISO Inferred from Sequence Orthology more info
part_of interleukin-12 receptor complex	NAS Non-traceable Author Statement more info	PubMed
part_of interleukin-23 receptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase JAK2

Names: JAK-2

NP_001041642.1

EC 2.7.10.2

NP_032439.2

EC 2.7.10.2

XP_006526776.1

EC 2.7.10.2

XP_006526777.1

EC 2.7.10.2

XP_006526778.1

EC 2.7.10.2

XP_011245457.1

EC 2.7.10.2

XP_017173557.1

EC 2.7.10.2

XP_036017342.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048177.3 → NP_001041642.1 tyrosine-protein kinase JAK2

See identical proteins and their annotated locations for NP_001041642.1

Status: VALIDATED

Source sequence(s)

AC119228, AC162456

Consensus CDS

CCDS37950.1

UniProtKB/Swiss-Prot

G5E852, Q62120, Q62124, Q7TQD0

Related

ENSMUSP00000025705.7, ENSMUST00000025705.7

Conserved Domains (6) summary

cd10379
Location:386 → 482

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

cd13333
Location:266 → 386

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

cd05078
Location:545 → 806

PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2

cd14205
Location:844 → 1127

PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

pfam18377
Location:143 → 261

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:39 → 134

FERM_F1; FERM F1 ubiquitin-like domain
NM_008413.4 → NP_032439.2 tyrosine-protein kinase JAK2

See identical proteins and their annotated locations for NP_032439.2

Status: VALIDATED

Source sequence(s)

AC119228, AC162456

Consensus CDS

CCDS37950.1

UniProtKB/Swiss-Prot

G5E852, Q62120, Q62124, Q7TQD0

Related

ENSMUSP00000064394.4, ENSMUST00000065796.10

Conserved Domains (6) summary

cd10379
Location:386 → 482

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

cd13333
Location:266 → 386

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

cd05078
Location:545 → 806

PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2

cd14205
Location:844 → 1127

PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

pfam18377
Location:143 → 261

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:39 → 134

FERM_F1; FERM F1 ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

29229006..29290495

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161449.1 → XP_036017342.1 tyrosine-protein kinase JAK2 isoform X5

UniProtKB/TrEMBL

A0A494BBB9

Related

ENSMUSP00000158405.2, ENSMUST00000236990.2

Conserved Domains (5) summary

cd10379
Location:386 → 482

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

cd13333
Location:266 → 386

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

pfam18377
Location:143 → 261

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:39 → 134

FERM_F1; FERM F1 ubiquitin-like domain

cl21453
Location:545 → 592

PKc_like; Protein Kinases, catalytic domain
XM_006526715.5 → XP_006526778.1 tyrosine-protein kinase JAK2 isoform X5

UniProtKB/TrEMBL

A0A494BBB9

Conserved Domains (5) summary

cd10379
Location:386 → 482

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

cd13333
Location:266 → 386

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

pfam18377
Location:143 → 261

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:39 → 134

FERM_F1; FERM F1 ubiquitin-like domain

cl21453
Location:545 → 592

PKc_like; Protein Kinases, catalytic domain
XM_006526713.5 → XP_006526776.1 tyrosine-protein kinase JAK2 isoform X2

Conserved Domains (6) summary

cd10379
Location:386 → 482

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

cd13333
Location:266 → 386

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

cd14205
Location:799 → 1082

PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

pfam18377
Location:143 → 261

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:39 → 134

FERM_F1; FERM F1 ubiquitin-like domain

cl21453
Location:548 → 761

PKc_like; Protein Kinases, catalytic domain
XM_011247155.3 → XP_011245457.1 tyrosine-protein kinase JAK2 isoform X1

See identical proteins and their annotated locations for XP_011245457.1

UniProtKB/Swiss-Prot

G5E852, Q62120, Q62124, Q7TQD0

Conserved Domains (6) summary

cd10379
Location:386 → 482

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

cd13333
Location:266 → 386

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

cd05078
Location:545 → 806

PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2

cd14205
Location:844 → 1127

PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

pfam18377
Location:143 → 261

FERM_F2; FERM F2 acyl-CoA binding protein-like domain

pfam18379
Location:39 → 134

FERM_F1; FERM F1 ubiquitin-like domain
XM_017318068.3 → XP_017173557.1 tyrosine-protein kinase JAK2 isoform X4

Conserved Domains (3) summary

cd05078
Location:140 → 401

PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2

cd14205
Location:439 → 722

PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

cl15255
Location:1 → 77

SH2; Src homology 2 (SH2) domain
XM_006526714.5 → XP_006526777.1 tyrosine-protein kinase JAK2 isoform X3

Conserved Domains (5) summary

cd10379
Location:190 → 286

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

cd13333
Location:70 → 190

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

cd05078
Location:349 → 610

PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2

cd14205
Location:648 → 931

PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

pfam18377
Location:10 → 65

FERM_F2; FERM F2 acyl-CoA binding protein-like domain