U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 [ Mus musculus (house mouse) ]

Gene ID: 16521, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Kcnj5provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 5provided by MGI
Primary source
MGI:MGI:104755
See related
Ensembl:ENSMUSG00000032034 AllianceGenome:MGI:104755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIR; GIRK4; KATP-1; Kir3.4
Summary
Predicted to enable inward rectifier potassium channel activity and voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. Predicted to be involved in cardiac conduction; potassium ion import across plasma membrane; and regulation of monoatomic ion transmembrane transport. Predicted to be located in T-tubule and external side of plasma membrane. Predicted to be part of I(KACh) inward rectifier potassium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; intestine; and liver lobe. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 14.0), liver E14 (RPKM 0.9) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kcnj5 in Genome Data Viewer
Location:
9 A4; 9 17.65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (32226002..32255640, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32314706..32344380, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 32 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23720 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23722 Neighboring gene STARR-seq mESC enhancer starr_23724 Neighboring gene STARR-seq mESC enhancer starr_23725 Neighboring gene STARR-positive B cell enhancer ABC_E9755 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32094558-32094858 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32157923-32158223 Neighboring gene STARR-positive B cell enhancer ABC_E38 Neighboring gene STARR-seq mESC enhancer starr_23730 Neighboring gene STARR-seq mESC enhancer starr_23731 Neighboring gene predicted gene, 39317 Neighboring gene predicted gene, 31755 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic Ablation of G Protein-Gated Inwardly Rectifying K(+) Channels Prevents Training-Induced Sinus Bradycardia. Bidaud I, et al. Front Physiol, 2020. PMID 33551824, Free PMC Article
  2. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. Kovoor P, et al. J Am Coll Cardiol, 2001 Jun 15. PMID 11419900
  3. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. Wickman K, et al. J Neurosci, 2000 Aug 1. PMID 10908597, Free PMC Article
  4. Predisposition to late-onset obesity in GIRK4 knockout mice. Perry CA, et al. Proc Natl Acad Sci U S A, 2008 Jun 10. PMID 18523006, Free PMC Article
  5. Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality. Toib A, et al. J Mol Cell Cardiol, 2012 Sep. PMID 22796573, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that potassium inwardly-rectifying channel subfamily J member 5 (Kcnj5) is important for baseline aldosterone secretion, but its importance is sex-limited at least in the mouse.
    Title: Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.
  2. histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2, Kcnj3, Kcnj5, Kcnj11, and Kcnh2)
    Title: Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.
  3. These results provide a novel molecular mechanism for autocrine negative feedback regulation of insulin secretion.
    Title: Autocrine insulin increases plasma membrane K(ATP) channel via PI3K-VAMP2 pathway in MIN6 cells.
  4. study establishes the role of f-channels in cardiac automaticity and indicates that arrhythmia related to HCN loss-of-function may be managed by pharmacological or genetic inhibition of GIRK4 channels
    Title: Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.
  5. expressed in outer sarcolemmas and ventricular t-tubular system of mouse heart
    Title: G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization.
  6. Data indicate taht m2R-RGS6-IKACh pathway sets heart rate variability independently from the autonomic input.
    Title: Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.
  7. the K(ATP) channel may have an important physiological role during early cardiac development.
    Title: Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality.
  8. Therefore, the lack of proper functioning of the cardio-protective K(ATP) system in the mdx cardiomyocytes may be part of the mechanism contributing to development of cardiac disease in dystrophic patients.
    Title: Dystrophin is required for the normal function of the cardio-protective K(ATP) channel in cardiomyocytes.
  9. Our present study reinforces a role for the sulfonylurea-sensitive KATP channel in cardioprotection.
    Title: Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation.
  10. Data suggest HL-1 cells express GIRK1/4 and M2 muscarinic receptors and are a good model to study acetylcholine-activated potassium currents.
    Title: HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to G-protein activated inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G-protein activated inward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables inward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in membrane repolarization during atrial cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane repolarization during atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of I(KACh) inward rectifier potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G protein-activated inward rectifier potassium channel 4
Names
cardiac inward rectifier
heart KATP channel
inward rectifier K(+) channel Kir3.4
potassium channel, inwardly rectifying subfamily J member 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411833.1 → NP_001398762.1  G protein-activated inward rectifier potassium channel 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132114
    UniProtKB/Swiss-Prot
    P48545, P97508, Q3TPX9
    Related
    ENSMUSP00000149000.2, ENSMUST00000214223.2

  2. NM_001411834.1 → NP_001398763.1  G protein-activated inward rectifier potassium channel 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132114
    UniProtKB/Swiss-Prot
    P48545, P97508, Q3TPX9

  3. NM_001411835.1 → NP_001398764.1  G protein-activated inward rectifier potassium channel 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132114
    UniProtKB/Swiss-Prot
    P48545, P97508, Q3TPX9

  4. NM_001411836.1 → NP_001398765.1  G protein-activated inward rectifier potassium channel 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132114

  5. NM_010605.6 → NP_034735.3  G protein-activated inward rectifier potassium channel 4 isoform 1

    See identical proteins and their annotated locations for NP_034735.3

    Status: VALIDATED

    Source sequence(s)
    AC132114
    Consensus CDS
    CCDS22952.1
    UniProtKB/Swiss-Prot
    P48545, P97508, Q3TPX9
    UniProtKB/TrEMBL
    Q9QYM1
    Related
    ENSMUSP00000034533.6, ENSMUST00000034533.7
    Conserved Domains (2) summary
    pfam01007
    Location:54 → 193
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:200 → 371
    IRK_C; Inward rectifier potassium channel C-terminal domain

RNA

  1. NR_157190.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132114

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    32226002..32255640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313154.3 → XP_017168643.1  G protein-activated inward rectifier potassium channel 4 isoform X1

    UniProtKB/TrEMBL
    Q9QYM1
    Conserved Domains (2) summary
    pfam01007
    Location:103 → 242
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:249 → 420
    IRK_C; Inward rectifier potassium channel C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48545.3 GenPept UniProtKB/Swiss-Prot:P48545

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous