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Kifc5b kinesin family member C5B [ Mus musculus (house mouse) ]

Gene ID: 16580, updated on 27-Nov-2024

Summary

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Official Symbol
Kifc5bprovided by MGI
Official Full Name
kinesin family member C5Bprovided by MGI
Primary source
MGI:MGI:2137414
See related
Ensembl:ENSMUSG00000024301 AllianceGenome:MGI:2137414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hset; KNSL2; Kifc5a
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; mitotic metaphase chromosome alignment; and mitotic spindle assembly. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human KIFC1 (kinesin family member C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 18.8), liver E14.5 (RPKM 13.5) and 18 other tissues See more
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Genomic context

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See Kifc5b in Genome Data Viewer
Location:
17 A3.3; 17 13.6 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27136065..27151553)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26917091..26932579)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17382 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene predicted gene, 41555 Neighboring gene STARR-seq mESC enhancer starr_42135 Neighboring gene STARR-seq mESC enhancer starr_42137 Neighboring gene microRNA 6967-1 Neighboring gene STARR-positive B cell enhancer ABC_E487 Neighboring gene microRNA 6968 Neighboring gene PHD finger protein 1 Neighboring gene cutA divalent cation tolerance homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of isoforms of a mitotic motor in mammalian spermatogenesis. Navolanic PM, et al. Biol Reprod, 2000 May. PMID 10775188
  2. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Saito N, et al. Neuron, 1997 Mar. PMID 9115736
  3. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Rousseaux MW, et al. Proc Natl Acad Sci U S A, 2012 Sep 25. PMID 23019375, Free PMC Article
  4. Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication. Christodoulou A, et al. J Cell Sci, 2006 May 15. PMID 16638812
  5. Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver. Nath S, et al. Mol Biol Cell, 2007 May. PMID 17360972, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIFC5A and the Nubp proteins in a common regulatory pathway involved in the control of centrosome duplication in mammalian cells.
    Title: Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC76666

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin family member C5B
Names
kinesin family c-terminal 5A
kinesin family c-terminal 5B
kinesin family member C5A
kinesin-related protein KIFC5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053173.2 → NP_444403.2  kinesin family member C5B

    Status: VALIDATED

    Source sequence(s)
    AC144621, AF221103, AI604818, AK081484, BB638629, BI733451
    Consensus CDS
    CCDS37517.1
    UniProtKB/TrEMBL
    A0A068BFR6, E9PUA5
    Related
    ENSMUSP00000077984.5, ENSMUST00000078961.6
    Conserved Domains (4) summary
    smart00129
    Location:309 → 665
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:307 → 664
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam07926
    Location:138 → 249
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam15233
    Location:169 → 298
    SYCE1; Synaptonemal complex central element protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27136065..27151553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016761.1: Suppressed sequence

    Description
    NM_016761.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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