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Kifc3 kinesin family member C3 [ Mus musculus (house mouse) ]

Gene ID: 16582, updated on 27-Nov-2024

Summary

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Official Symbol
Kifc3provided by MGI
Official Full Name
kinesin family member C3provided by MGI
Primary source
MGI:MGI:109202
See related
Ensembl:ENSMUSG00000031788 AllianceGenome:MGI:109202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity and microtubule binding activity. Acts upstream of or within Golgi organization and microtubule-based process. Located in Golgi apparatus. Part of kinesin complex. Is expressed in several structures, including brain; genitourinary system; gut; liver and biliary system; and respiratory system. Orthologous to human KIFC3 (kinesin family member C3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 47.2), lung adult (RPKM 23.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Kifc3 in Genome Data Viewer
Location:
8 C5; 8 47.12 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95826456..95929454, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95099828..95202826, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51544 Neighboring gene adhesion G protein-coupled receptor G3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97604749-97604932 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene katanin p80 (WD40-containing) subunit B 1 Neighboring gene STARR-seq mESC enhancer starr_22375 Neighboring gene predicted gene, 31224 Neighboring gene predicted gene, 31036 Neighboring gene STARR-seq mESC enhancer starr_22381 Neighboring gene predicted gene, 31277 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97769227-97769421 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97771323-97771506 Neighboring gene STARR-positive B cell enhancer ABC_E3796 Neighboring gene cyclic nucleotide gated channel beta 1 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis. Ju JQ, et al. Cell Commun Signal, 2024 Mar 29. PMID 38553728, Free PMC Article
  2. KIFC3 promotes the proliferation, migration and invasion of non-small cell lung cancer through the PI3K/AKT signaling pathway. Ma Y, et al. Sci Rep, 2024 Sep 3. PMID 39227687, Free PMC Article
  3. Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. Bejarano E, et al. Aging Cell, 2018 Aug. PMID 29845728, Free PMC Article
  4. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3. Yang Z, et al. Mol Cell Biol, 2001 Feb. PMID 11154264, Free PMC Article
  5. Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells. Dietrich D, et al. Biochim Biophys Acta, 2013 Dec. PMID 23954441

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIFC3 promotes the proliferation, migration and invasion of non-small cell lung cancer through the PI3K/AKT signaling pathway.
    Title: KIFC3 promotes the proliferation, migration and invasion of non-small cell lung cancer through the PI3K/AKT signaling pathway.
  2. Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis.
    Title: Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis.
  3. The study connects defects in intracellular trafficking with insufficient autophagy in old organisms and identifies Kifc3 as a novel target for future interventions aiming at correcting autophagic activity with anti-aging purposes.
    Title: Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging.
  4. KifC3 may play a regulatory role in minus-end directed peroxisomal transport for example by blocking the motor function of dynein at peroxisomes.
    Title: Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells.
  5. KIFC3 plays a complementary role in Golgi positioning and integration
    Title: Role of KIFC3 motor protein in Golgi positioning and integration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in zonula adherens maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in zonula adherens maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in zonula adherens ISO
Inferred from Sequence Orthology
more info
  
located_in zonula adherens ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
kinesin-like protein KIFC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145831.2 → NP_001139303.1  kinesin-like protein KIFC3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC103935
    Consensus CDS
    CCDS52639.1
    UniProtKB/TrEMBL
    E9PWU7
    Related
    ENSMUSP00000126784.2, ENSMUST00000169748.9
    Conserved Domains (2) summary
    COG1196
    Location:38 → 355
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:405 → 722
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  2. NM_001145832.2 → NP_001139304.1  kinesin-like protein KIFC3 isoform c

    See identical proteins and their annotated locations for NP_001139304.1

    Status: VALIDATED

    Source sequence(s)
    AC103935
    Consensus CDS
    CCDS52638.1
    UniProtKB/TrEMBL
    A0A1D5RLM0
    Related
    ENSMUSP00000148425.2, ENSMUST00000213004.2
    Conserved Domains (3) summary
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:312 → 629
    Kinesin; Kinesin motor domain
    cl12013
    Location:38 → 167
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_001372312.1 → NP_001359241.1  kinesin-like protein KIFC3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC102518, AC103935
    Conserved Domains (2) summary
    COG1196
    Location:230 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:597 → 924
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  4. NM_001372313.1 → NP_001359242.1  kinesin-like protein KIFC3 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC102518, AC103935
    Conserved Domains (2) summary
    COG1196
    Location:181 → 498
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:548 → 875
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  5. NM_001372314.1 → NP_001359243.1  kinesin-like protein KIFC3 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC103935
    Conserved Domains (2) summary
    COG1196
    Location:181 → 498
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:548 → 875
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  6. NM_001372315.1 → NP_001359244.1  kinesin-like protein KIFC3 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC103935
    Conserved Domains (2) summary
    TIGR02168
    Location:111 → 438
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:441 → 768
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  7. NM_001372316.1 → NP_001359245.1  kinesin-like protein KIFC3 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC103935
    Conserved Domains (3) summary
    TIGR02168
    Location:58 → 367
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:370 → 697
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl27170
    Location:6 → 86
    DUF460; Protein of unknown function (DUF460)

  8. NM_001372317.1 → NP_001359246.1  kinesin-like protein KIFC3 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC103935
    Conserved Domains (3) summary
    TIGR02168
    Location:58 → 367
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:370 → 697
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl27170
    Location:6 → 86
    DUF460; Protein of unknown function (DUF460)

  9. NM_001414042.1 → NP_001400971.1  kinesin-like protein KIFC3 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC103935

  10. NM_010631.3 → NP_034761.3  kinesin-like protein KIFC3 isoform a

    See identical proteins and their annotated locations for NP_034761.3

    Status: VALIDATED

    Source sequence(s)
    AC103935
    Consensus CDS
    CCDS52640.1
    UniProtKB/Swiss-Prot
    O35072, O35231, Q1WNZ8, Q3UX36, Q3V0U4, Q6NS71, Q8R3Y4, Q91YQ2, Q99KP7
    Related
    ENSMUSP00000034240.8, ENSMUST00000034240.15
    Conserved Domains (3) summary
    cd01366
    Location:441 → 768
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:449 → 766
    Kinesin; Kinesin motor domain
    cl12013
    Location:175 → 337
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    95826456..95929454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530723.4 → XP_006530786.1  kinesin-like protein KIFC3 isoform X6

    Conserved Domains (2) summary
    TIGR02168
    Location:160 → 487
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:490 → 817
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  2. XM_030243308.2 → XP_030099168.1  kinesin-like protein KIFC3 isoform X7

    Conserved Domains (2) summary
    TIGR02168
    Location:160 → 487
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:490 → 817
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  3. XM_006530718.5 → XP_006530781.1  kinesin-like protein KIFC3 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:229 → 546
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:596 → 923
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  4. XM_006530720.5 → XP_006530783.1  kinesin-like protein KIFC3 isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:230 → 547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:597 → 924
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  5. XM_030243309.2 → XP_030099169.1  kinesin-like protein KIFC3 isoform X8

    Conserved Domains (2) summary
    TIGR02168
    Location:111 → 438
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:441 → 768
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  6. XM_006530721.4 → XP_006530784.1  kinesin-like protein KIFC3 isoform X4

    See identical proteins and their annotated locations for XP_006530784.1

    Conserved Domains (2) summary
    COG1196
    Location:181 → 498
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:548 → 875
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  7. XM_036153766.1 → XP_036009659.1  kinesin-like protein KIFC3 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:227 → 544
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:594 → 921
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  8. XM_036153768.1 → XP_036009661.1  kinesin-like protein KIFC3 isoform X9

    Conserved Domains (2) summary
    COG1196
    Location:38 → 355
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:405 → 732
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  9. XM_036153769.1 → XP_036009662.1  kinesin-like protein KIFC3 isoform X9

    Conserved Domains (2) summary
    COG1196
    Location:38 → 355
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:405 → 732
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  10. XM_036153770.1 → XP_036009663.1  kinesin-like protein KIFC3 isoform X11

    Conserved Domains (2) summary
    COG1196
    Location:35 → 305
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  11. XM_006530726.5 → XP_006530789.1  kinesin-like protein KIFC3 isoform X10

    Conserved Domains (2) summary
    COG1196
    Location:3 → 320
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:370 → 697
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  12. XM_006530724.5 → XP_006530787.1  kinesin-like protein KIFC3 isoform X9

    See identical proteins and their annotated locations for XP_006530787.1

    Conserved Domains (2) summary
    COG1196
    Location:38 → 355
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:405 → 732
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35231.4 GenPept UniProtKB/Swiss-Prot:O35231

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