Klc2 kinesin light chain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klc2provided by MGI
Official Full Name: kinesin light chain 2provided by MGI
Primary source: MGI:MGI:107953
See related: Ensembl:ENSMUSG00000024862 AllianceGenome:MGI:107953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KLC 2; KLC-2; 8030455F02Rik
Summary: Enables kinesin binding activity. Acts upstream of or within axo-dendritic transport. Located in ciliary rootlet; cytosol; and neuron projection. Part of kinesin complex. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in SPOAN syndrome. Orthologous to human KLC2 (kinesin light chain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 59.4), cortex adult (RPKM 42.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.25 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5157774..5168326, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5107746..5118298, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human.
Title: Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human.
structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding
Title: Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
KLC2 is a cellular target of GSK-3beta capable of regulating synaptic plasticity, particularly AMPA receptor trafficking, as well as mood-associated behaviors in animal models
Title: A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary rootlet	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary rootlet	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin light chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369360.1 → NP_001356289.1 kinesin light chain 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC124502

Consensus CDS

CCDS37889.1

UniProtKB/TrEMBL

D3YXZ3, Q91YS4

Related

ENSMUSP00000025798.7, ENSMUST00000025798.13

Conserved Domains (3) summary

TIGR02168
Location:9 → 139

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00006
Location:282 → 310

TPR; TPR repeat [structural motif]

pfam13424
Location:238 → 314

TPR_12; Tetratricopeptide repeat
NM_001369361.1 → NP_001356290.1 kinesin light chain 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC124502

UniProtKB/TrEMBL

D3YXZ3

Conserved Domains (3) summary

TIGR02168
Location:9 → 139

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00006
Location:282 → 310

TPR; TPR repeat [structural motif]

pfam13424
Location:238 → 314

TPR_12; Tetratricopeptide repeat
NM_001369362.1 → NP_001356291.1 kinesin light chain 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC124502

UniProtKB/TrEMBL

D3YXZ3

Conserved Domains (3) summary

TIGR02168
Location:9 → 139

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00006
Location:282 → 310

TPR; TPR repeat [structural motif]

pfam13424
Location:238 → 314

TPR_12; Tetratricopeptide repeat
NM_008451.3 → NP_032477.2 kinesin light chain 2 isoform 1

See identical proteins and their annotated locations for NP_032477.2

Status: VALIDATED

Source sequence(s)

AC124502

Consensus CDS

CCDS37889.1

UniProtKB/TrEMBL

D3YXZ3, Q91YS4

Related

ENSMUSP00000112262.2, ENSMUST00000116563.8

Conserved Domains (3) summary

TIGR02168
Location:9 → 139

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00006
Location:282 → 310

TPR; TPR repeat [structural motif]

pfam13424
Location:238 → 314

TPR_12; Tetratricopeptide repeat