Klra5 killer cell lectin-like receptor, subfamily A, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klra5provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily A, member 5provided by MGI
Primary source: MGI:MGI:101903
See related: Ensembl:ENSMUSG00000030173 AllianceGenome:MGI:101903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly49e
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jan 2025]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129874715..129890188, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129898988..129913237, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ly49E is highly expressed on epidermal gammadelta T cells and liver NK cells, this receptor does not play a major role in the control of skin tumour formation or in lung and liver tumour development.
Title: Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.
this study shows that Ly49E expression on intraepithelial lymphocytes does not influence the development or progression of intestinal cancer
Title: The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.
Ly49E is expressed on a high proportion of CD8alphaalpha-positive intestinal intraepithelial lymphocytes.
Title: Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases.
Ly49E expression is not crucial for liver NK cell differentiation during ontogeny
Title: Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.
Two Ly49e expression pathways have been identified in the intraepithelial resting and activated gammadelta T cells.
Title: Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.
Ly49E is expressed in a probabilistic manner in adult natural killer (NK)cells and T cells.
Title: Mice lacking Ly49E show normal NK cell development and provide evidence for probabilistic expression of Ly49E in NK cells and T cells.
addition of uPA to Ly49E-positive adult and fetal NK cells inhibits interferon-gamma secretion and reduces their cytotoxic potential, respectively
Title: Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.
NK cells developing in vitro from fetal progenitors in the presence of IL-2 fact express high levels of at least one previously uncharacterized member of the Ly49 family, most likely Ly49E.
Title: NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2.
Inhibitory receptor Ly49E is expressed on mature fetal thymic and adult epidermal TCR Vgamma3+ lymphocytes.
Title: Expression of inhibitory receptors Ly49E and CD94/NKG2 on fetal thymic and adult epidermal TCR V gamma 3 lymphocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

Klra5 (e-PCR), detects polymorphism
- UniSTS:143713

NoName (e-PCR)
- UniSTS:493159

NoName (e-PCR)
- UniSTS:491252

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: killer cell lectin-like receptor 5

Names: Ly49E receptor; T-cell surface glycoprotein Ly-49E; class I MHC receptor KLRA5; ly-49e; lymphocyte antigen 49e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008463.2 → NP_032489.1 killer cell lectin-like receptor 5

See identical proteins and their annotated locations for NP_032489.1

Status: VALIDATED

Source sequence(s)

AC090563, U10091

Consensus CDS

CCDS20596.1

UniProtKB/Swiss-Prot

Q60652

UniProtKB/TrEMBL

Q548A2, Q6IVG1

Related

ENSMUSP00000014683.7, ENSMUST00000014683.13

Conserved Domains (2) summary

cd03593
Location:145 → 259

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 157

Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

129874715..129890188 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165889.1 → XP_036021782.1 killer cell lectin-like receptor 5 isoform X1

UniProtKB/TrEMBL

Q6IVG1

Conserved Domains (2) summary

cd03593
Location:115 → 229

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:35 → 127

Ly49; Ly49-like protein, N-terminal region
XM_036165890.1 → XP_036021783.1 killer cell lectin-like receptor 5 isoform X2

Conserved Domains (2) summary

cd03593
Location:115 → 191

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:35 → 127

Ly49; Ly49-like protein, N-terminal region