Cygb cytoglobin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cygbprovided by RGD
Official Full Name: cytoglobinprovided by RGD
Primary source: RGD:69415
See related: EnsemblRapid:ENSRNOG00000011541 AllianceGenome:RGD:69415
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glnf; Stap; Staap
Summary: Enables heme binding activity; nitric oxide dioxygenase activity, heme protein as donor; and peroxidase activity. Involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of hepatic stellate cell activation; and nitric oxide catabolic process. Located in cytoplasm. Used to study liver cirrhosis and renal fibrosis. Biomarker of kidney disease and liver cirrhosis. Orthologous to human CYGB (cytoglobin). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 135.3), Kidney (RPKM 111.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (102376506..102386272, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (101877675..101887442, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (105618325..105628091, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and NOD activity of Cygb represents a strategy for the treatment of cardiovascular disease
Title: Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall.
This result suggests that Cygb possibly participates in the development of degenerative diseases; our findings also support the possible biological role of Cygb related to peroxidase activity.
Title: Intermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin.
The reduction of neonatal HI injury by CYGB may be due in part to antioxidant and antiapoptotic mechanisms and by promoting angiogenesis.
Title: Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model.
may be involved in the healing process of gastric mucosal injuries in the late phase without angiogenesis
Title: Cytoglobin may be involved in the healing process of gastric mucosal injuries in the late phase without angiogenesis.
These findings show for the first that Cygb serves as a defensive mechanism against oxidative stress both in vitro and in vivo.
Title: Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions.
The induction of cytoglobin in islets may reduce cell loss from chronic hypoxia and may be a useful adjunct to islet transplantation.
Title: Reduction of ischemic cell death in cultured Islets of Langerhans by the induction of cytoglobin.
Cygb plays an important role in protection of the kidney against fibrosis via the amelioration of oxidative stress both in vitro and in vivo
Title: Cytoglobin, a novel globin, plays an antifibrotic role in the kidney.
Cygb has a nitric-oxide dioxygenase function and ascorbate and cytochrome b(5) have roles as reductants
Title: Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes.
Cygb but not Ngb may protect cerebellar cells from the chronic presence of carbon monoxide exposure during prenatal and postnatal development.
Title: Neuroglobin, cytoglobin, and transcriptional profiling of hypoxia-related genes in the rat cerebellum after prenatal chronic very mild carbon monoxide exposure (25 ppm).
cytoglobin contributes to cell-mediated NO dioxygenation and represents an important NO sink in the vascular wall.
Title: Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH133332 (e-PCR)
- UniSTS:216615

Tbxas1 (e-PCR), detects polymorphism
- UniSTS:265585

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbon monoxide binding	ISO Inferred from Sequence Orthology more info
enables catalase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables nitric oxide dioxygenase activity, heme protein as donor	IDA Inferred from Direct Assay more info	PubMed
enables nitric oxide dioxygenase activity, heme protein as donor	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	ISO Inferred from Sequence Orthology more info
enables superoxide dismutase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hepatic stellate cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in nitric oxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytoglobin

Names: HGb; globin f; histoglobin; nitric oxygen dioxygenase CYGB; nitrite reductase CYGB; pseudoperoxidase CYGB; stellate cell activation-associated protein; superoxide dismutase CYGB

NP_570100.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.