U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fgf12 fibroblast growth factor 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170630, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Symbol
Fgf12provided by RGD
Full Name
fibroblast growth factor 12provided by RGD
Primary source
RGD:620163
See related
EnsemblRapid:ENSRNOG00000090378 AllianceGenome:RGD:620163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fhf1; Fgf1a; Fhf1b
Summary
Enables sodium channel regulator activity and transmembrane transporter binding activity. Involved in negative regulation of cation channel activity; regulation of membrane depolarization; and regulation of sodium ion transmembrane transporter activity. Predicted to be located in synapse. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 47. Orthologous to human FGF12 (fibroblast growth factor 12). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 421.1), Heart (RPKM 185.9) and 1 other tissue See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fgf12 in Genome Data Viewer
Location:
11q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (85501947..86069543)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (71997151..72564757)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (75606360..76171078)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene Mab-21 domain containing 2 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene Neighboring gene uncharacterized LOC134481099 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102548576 Neighboring gene coiled-coil domain containing 50

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. Wildburger NC, et al. Mol Cell Proteomics, 2015 May. PMID 25724910, Free PMC Article
  2. Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate. Song SH, et al. Arterioscler Thromb Vasc Biol, 2016 Sep. PMID 27470512
  3. MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells. Fan Q, et al. J Stroke Cerebrovasc Dis, 2022 Apr. PMID 35093630
  4. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Goldfarb M, et al. Neuron, 2007 Aug 2. PMID 17678857, Free PMC Article
  5. Fibroblast growth factor homologous factor 1B binds to the C terminus of the tetrodotoxin-resistant sodium channel rNav1.9a (NaN). Liu Cj, et al. J Biol Chem, 2001 Jun 1. PMID 11376006

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.
    Title: MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.
  2. FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation.
    Title: Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate.
  3. Fibroblast growth factor 12 is a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in the rat brain.
    Title: Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.
  4. Sodium channels in Fhf1-/-Fhf4-/- granule neurons inactivate at more negative membrane potential, inactivate more rapidly, and are slower to recover from the inactivated state.
    Title: Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane depolarization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neuronal action potential IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuronal action potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of voltage-gated sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fibroblast growth factor 12
Names
FGF-12
FHF-1
fibroblast growth factor 1a
fibroblast growth factor homologous factor 1
fibroblast growth factor homologous factor 1b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395084.1 → NP_001382013.1  fibroblast growth factor 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6JRX5, A6JRX6
    Related
    ENSRNOP00000002650.2, ENSRNOT00000002650.6
    Conserved Domains (1) summary
    pfam00167
    Location:12 → 136
    FGF; Fibroblast growth factor

  2. NM_130814.2 → NP_570827.2  fibroblast growth factor 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    P61150
    UniProtKB/TrEMBL
    A0A7U3L6G2
    Related
    ENSRNOP00000111324.1, ENSRNOT00000158744.1
    Conserved Domains (1) summary
    pfam00167
    Location:74 → 198
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    85501947..86069543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597854.3 → XP_017453343.1  fibroblast growth factor 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2F9, A6JRX6
    Conserved Domains (1) summary
    pfam00167
    Location:38 → 162
    FGF; Fibroblast growth factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61150.1 GenPept UniProtKB/Swiss-Prot:P61150

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools