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Dynlrb1 dynein light chain roadblock-type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170714, updated on 27-Nov-2024

Summary

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Official Symbol
Dynlrb1provided by RGD
Official Full Name
dynein light chain roadblock-type 1provided by RGD
Primary source
RGD:619910
See related
EnsemblRapid:ENSRNOG00000025715 AllianceGenome:RGD:619910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
km23; Dncl2a
Summary
Predicted to enable dynein intermediate chain binding activity and identical protein binding activity. Involved in visual behavior. Located in cytoplasm. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 746.8), Brain (RPKM 696.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dynlrb1 in Genome Data Viewer
Location:
3q41
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164197892..164224409)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143742427..143764227)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150761329..150782493)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12, pseudogene 7 Neighboring gene uncharacterized LOC102549926 Neighboring gene itchy E3 ubiquitin protein ligase Neighboring gene U2 spliceosomal RNA Neighboring gene microtubule-associated protein 1 light chain 3 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Light-induced down-regulation of the rat class 1 dynein-associated protein robl/LC7-like gene in visual cortex. Ye F, et al. J Biol Chem, 2000 Sep 1. PMID 10816553
  2. N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points. Islam MA, et al. Exp Mol Med, 2015 Aug 14. PMID 26272270, Free PMC Article
  3. The Roadblock light chains are ubiquitous components of cytoplasmic dynein that form homo- and heterodimers. Nikulina K, et al. Cell Motil Cytoskeleton, 2004 Apr. PMID 14752807
  4. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. Jiang J, et al. Gene, 2001 Dec 27. PMID 11750132
  5. Cytoplasmic dynein. Allan VJ. Biochem Soc Trans, 2011 Oct. PMID 21936784

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction between NAGK and Dynlrb1 frequently occurs at dendritic branch points.
    Title: N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in retrograde axonal transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in visual behavior IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein light chain roadblock-type 1
Names
BLP
bithoraxoid-like protein
dynein light chain 2A, cytoplasmic
dynein, cytoplasmic, light chain 2A
dynein-associated protein Km23
dynein-associated protein RKM23
robl/LC7-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131910.5 → NP_571985.1  dynein light chain roadblock-type 1

    See identical proteins and their annotated locations for NP_571985.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P62628
    UniProtKB/TrEMBL
    A0A8I6A1D3, A6KI20
    Related
    ENSRNOP00000110838.1, ENSRNOT00000122357.1
    Conserved Domains (1) summary
    smart00960
    Location:4 → 91
    Robl_LC7; Roadblock/LC7 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164197892..164224409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283030.1 → XP_063139100.1  dynein light chain roadblock-type 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2M7
    Related
    ENSRNOP00000085894.1, ENSRNOT00000106591.2

  2. XM_039104174.2 → XP_038960102.1  dynein light chain roadblock-type 1 isoform X2

    Conserved Domains (1) summary
    smart00960
    Location:23 → 95
    Robl_LC7; Roadblock/LC7 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62628.3 GenPept UniProtKB/Swiss-Prot:P62628

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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