Rtn4ip1 reticulon 4 interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rtn4ip1provided by MGI
Official Full Name: reticulon 4 interacting protein 1provided by MGI
Primary source: MGI:MGI:2178759
See related: Ensembl:ENSMUSG00000019864 AllianceGenome:MGI:2178759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NIMP; D10Ertd690e
Summary: Predicted to enable NADPH dehydrogenase (quinone) activity. Involved in regulation of dendrite development. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 16.9), kidney adult (RPKM 9.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B2; 10 23.12 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (43777772..43823860)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (43901807..43947863)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis.
Title: Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236343

AU015759 (e-PCR)
- UniSTS:167030

G64304 (e-PCR)
- UniSTS:186573

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADPH dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: reticulon-4-interacting protein 1, mitochondrial

Names: NOGO-interacting mitochondrial protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130892.5 → NP_570962.2 reticulon-4-interacting protein 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_570962.2

Status: VALIDATED

Source sequence(s)

AC153536, AC158637, AK050324

Consensus CDS

CCDS23823.1

UniProtKB/Swiss-Prot

Q8R1T0, Q924D0

UniProtKB/TrEMBL

A0A0R4J0S3

Related

ENSMUSP00000060940.6, ENSMUST00000054418.12

Conserved Domains (2) summary

cd08248
Location:43 → 394

RTN4I1; Human Reticulon 4 Interacting Protein 1

COG0604
Location:43 → 395

Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RNA

NR_152603.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153536, AC158637, AK050324, CF165433

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

43777772..43823860

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155653.1 → XP_036011546.1 reticulon-4-interacting protein 1, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q8R1T0, Q924D0

Conserved Domains (1) summary

cd08248
Location:43 → 363

RTN4I1; Human Reticulon 4 Interacting Protein 1