Glmn glomulin, FKBP associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glmnprovided by MGI
Official Full Name: glomulin, FKBP associated proteinprovided by MGI
Primary source: MGI:MGI:2141180
See related: Ensembl:ENSMUSG00000029276 AllianceGenome:MGI:2141180
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fap48; Fap68; 9330160J16Rik
Summary: Predicted to enable hepatocyte growth factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase inhibitor activity. Acts upstream of or within circulatory system development and neural tube closure. Predicted to be part of Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; and Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including arterial system; respiratory system; skeleton; skin; and urinary system. Human ortholog(s) of this gene implicated in arteriovenous malformation; glomangioma; and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 4.4), CNS E18 (RPKM 3.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 52.23 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (107696828..107745754, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (107548962..107597888, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation.
Title: Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.
Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase and glomulin (GLMN).
Title: Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.
The glomulin expression during murine development (E9.5 days post-coitum until adulthood) by non-radioactive in situ hybridization was studied.
Title: Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hepatocyte growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables hepatocyte growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of cullin-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glomulin

Names: FAP; FK506-binding protein-associated protein; FKBP-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161738.1 → NP_001155210.1 glomulin isoform a

See identical proteins and their annotated locations for NP_001155210.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC134411, AK034160

Consensus CDS

CCDS19505.1

UniProtKB/Swiss-Prot

Q3TFR5, Q8BZM1, Q99LB8

UniProtKB/TrEMBL

Q3TMW7

Related

ENSMUSP00000080766.3, ENSMUST00000082121.9

Conserved Domains (1) summary

pfam08568
Location:1 → 527

Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
NM_001161739.1 → NP_001155211.1 glomulin isoform b

See identical proteins and their annotated locations for NP_001155211.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.

Source sequence(s)

AC117574, AC134411, AK169045

Consensus CDS

CCDS51587.1

UniProtKB/TrEMBL

Q3T9A5, Q3TMW7

Related

ENSMUSP00000098509.4, ENSMUST00000100949.10

Conserved Domains (1) summary

pfam08568
Location:1 → 462

Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin
NM_133248.2 → NP_573511.2 glomulin isoform a

See identical proteins and their annotated locations for NP_573511.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC134411, AK169045, BY013339

Consensus CDS

CCDS19505.1

UniProtKB/Swiss-Prot

Q3TFR5, Q8BZM1, Q99LB8

UniProtKB/TrEMBL

Q3TMW7

Related

ENSMUSP00000077168.7, ENSMUST00000078021.13

Conserved Domains (1) summary

pfam08568
Location:1 → 527

Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

107696828..107745754 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249410.3 → XP_011247712.1 glomulin isoform X2

Conserved Domains (1) summary

pfam08568
Location:14 → 224

Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
XM_030254179.1 → XP_030110039.1 glomulin isoform X2

Conserved Domains (1) summary

pfam08568
Location:14 → 224

Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
XM_006534800.5 → XP_006534863.1 glomulin isoform X1

See identical proteins and their annotated locations for XP_006534863.1

UniProtKB/Swiss-Prot

Q3TFR5, Q8BZM1, Q99LB8

UniProtKB/TrEMBL

Q3TMW7

Conserved Domains (1) summary

pfam08568
Location:1 → 527

Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
XM_017320694.3 → XP_017176183.1 glomulin isoform X2

Conserved Domains (1) summary

pfam08568
Location:14 → 224

Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin