Ucn2 urocortin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ucn2provided by RGD
Official Full Name: urocortin 2provided by RGD
Primary source: RGD:620765
See related: EnsemblRapid:ENSRNOG00000020579 AllianceGenome:RGD:620765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ucn3
Summary: Enables corticotropin-releasing hormone receptor 2 binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; cellular response to hypoxia; and negative regulation of gonadotropin secretion. Located in extracellular space. Biomarker of colitis. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human UCN2 (urocortin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 2.2), Uterus (RPKM 1.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118516111..118517660)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109637624..109639173)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117727216..117728765)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight Loss in Rats.
Title: Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight Loss in Rats.
UCN2 can modulate electrical remodeling of the myocardium and hemodynamics.
Title: The effects of vasoactive peptide urocortin 2 on hemodynamics in spontaneous hypertensive rat and the role of L-type calcium channel and CRFR2.
UCN2 could significantly inhibit the firing rate of 84% of the tested striatal neurons, and its inhibitory effect followed a concentration-dependent manner.
Title: The effects of neuropeptide urocortin 2 on the spontaneous discharge and glutamatergic neurotransmission of striatum neurons.
the stress-triggered rise in glucocorticoids is involved in the induction of Ucn2 mRNA by immobilization stress which may allow Ucn2 to act in an autocrine/paracrine fashion to modulate adrenomedullary function or as an endocrine hormone
Title: Stress-induced changes in gene expression of urocortin 2 and other CRH peptides in rat adrenal medulla: involvement of glucocorticoids.
The differentiated behavioral stress responses were reflected by gene expression changes in the pituitary. Alterations in the mRNA levels of Crh, Ucn2 and Ucn3 in the pituitary might confirm the paracrine and/or autocrine effects of these peptides
Title: Differential stress response in rats subjected to chronic mild stress is accompanied by changes in CRH-family gene expression at the pituitary level.
Data suggest that estrogens down-regulate Ucn2 expression in uterus; at 9 weeks, mRNA expression levels and contents of Ucn2 in uterus are lower in proestrus than in diestrus; plasma Ucn2 levels do not differ between the two estrous cycle phases.
Title: Estrogens downregulate urocortin 2 expression in rat uterus.
CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise
Title: Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress.
Diet-induced obesity rats showed preexisting, heritable deficit in the maintenance of postmeal satiety and a reduced sensitivity to anorectic CRF(2) stimulation by urocortin 2.
Title: Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2.
Ucn 2 is involved in the regulatory mechanism of the expression and secretion of gonadotropins through its tonic and inhibitory action on gonadotrophs in a paracrine manner.
Title: Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins.
palatable high-fat diet is inversely associated with anxiety and Ucn2 signaling may play a role in this association
Title: Inverse association of high-fat diet preference and anxiety-like behavior: a putative role for urocortin 2.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

AW209154 (e-PCR)
- UniSTS:179978

BI277776 (e-PCR)
- UniSTS:243851

RH135255 (e-PCR)
- UniSTS:218532

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables corticotropin-releasing hormone receptor 2 binding	IEA Inferred from Electronic Annotation more info
enables corticotropin-releasing hormone receptor 2 binding	IPI Inferred from Physical Interaction more info	PubMed
enables corticotropin-releasing hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables corticotropin-releasing hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of follicle-stimulating hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of luteinizing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in tissue regeneration	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: urocortin-2

Names: ucn II; urocortin 3; urocortin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.