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Rbm14 RNA binding motif protein 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170900, updated on 4-Jan-2025

Summary

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Official Symbol
Rbm14provided by RGD
Official Full Name
RNA binding motif protein 14provided by RGD
Primary source
RGD:620542
See related
EnsemblRapid:ENSRNOG00000045568 AllianceGenome:RGD:620542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CoAA
Summary
Predicted to enable mRNA binding activity; nuclear receptor coactivator activity; and splicing factor binding activity. Predicted to be involved in several processes, including centriole assembly; negative regulation of centriole replication; and positive regulation of macromolecule biosynthetic process. Predicted to act upstream of or within apoptotic process; gastrulation; and regulation of response to DNA integrity checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in nuclear speck. Orthologous to several human genes including RBM14 (RNA binding motif protein 14). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 125.8), Adrenal (RPKM 116.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbm14 in Genome Data Viewer
Location:
1q43
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211476298..211535077, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202076940..202105688, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220048740..220067124, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene uncharacterized LOC102553046 Neighboring gene spectrin, beta, non-erythrocytic 2 Neighboring gene proteasome subunit alpha type-3-like Neighboring gene RNA binding motif protein 4B Neighboring gene RNA binding motif protein 4 Neighboring gene copper chaperone for superoxide dismutase Neighboring gene coiled-coil domain containing 87

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors. Li X, et al. J Cell Biochem, 2009 Oct 1. PMID 19585539, Free PMC Article
  2. The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons. Simpson MT, et al. Mol Cell Neurosci, 2015 Sep. PMID 26306672, Free PMC Article
  3. RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity. Shiratsuchi G, et al. EMBO J, 2015 Jan 2. PMID 25385835, Free PMC Article
  4. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Iwasaki T, et al. Endocrinology, 2005 Sep. PMID 15919756
  5. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). Iwasaki T, et al. J Biol Chem, 2001 Sep 7. PMID 11443112

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study idnetifed that the RBM14 as inhibitors of neurite outgrowth.
    Title: The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons.
  2. CoAA binds Runx2 and prevents Runx2 binding to DNA
    Title: Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables splicing factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in centriole assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gastrulation ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of response to DNA integrity checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein 14
Names
coactivator activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133388.1 → NP_596879.1  RNA-binding protein 14

    See identical proteins and their annotated locations for NP_596879.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HYZ2, A6HYZ3, M0R9Q1
    Related
    ENSRNOP00000066778.1, ENSRNOT00000072373.5
    Conserved Domains (3) summary
    TIGR01628
    Location:3 → 280
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12608
    Location:1 → 71
    RRM1_CoAA; RNA recognition motif 1 (RRM1) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cd12609
    Location:79 → 146
    RRM2_CoAA; RNA recognition motif 2 (RRM2) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    211476298..211535077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272688.1 → XP_063128758.1  RNA-binding protein 14 isoform X2

  2. XM_063272714.1 → XP_063128784.1  RNA-binding protein 14 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A8X6, A0A8J8YGL2, A6HYY8

  3. XM_063272752.1 → XP_063128822.1  RNA-binding protein 14 isoform X4

  4. XM_039084839.2 → XP_038940767.1  RNA-binding protein 14 isoform X1

    UniProtKB/TrEMBL
    A6HYZ3, M0R3R6
    Conserved Domains (3) summary
    TIGR01628
    Location:3 → 280
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12608
    Location:1 → 71
    RRM1_CoAA; RNA recognition motif 1 (RRM1) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cd12609
    Location:79 → 146
    RRM2_CoAA; RNA recognition motif 2 (RRM2) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)

RNA

  1. XR_010057234.1 RNA Sequence

  2. XR_010057218.1 RNA Sequence

  3. XR_010057187.1 RNA Sequence

  4. XR_010057152.1 RNA Sequence

  5. XR_010057136.1 RNA Sequence

  6. XR_010057081.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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