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Mrpl17 mitochondrial ribosomal protein L17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171061, updated on 4-Jan-2025

Summary

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Official Symbol
Mrpl17provided by RGD
Official Full Name
mitochondrial ribosomal protein L17provided by RGD
Primary source
RGD:70943
See related
EnsemblRapid:ENSRNOG00000019497 AllianceGenome:RGD:70943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
L17mt; MRP-L17
Summary
Predicted to enable protein domain specific binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL17 (mitochondrial ribosomal protein L17). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 560.0), Adrenal (RPKM 413.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl17 in Genome Data Viewer
Location:
1q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169574010..169575699, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (160162181..160163870, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170652293..170653982, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1 Neighboring gene uncharacterized LOC134483767 Neighboring gene GTPase, very large interferon inducible 1 Neighboring gene egl-9 family hypoxia-inducible factor 1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. Tchernev VT, et al. Mol Med, 2002 Jan. PMID 11984006, Free PMC Article
  2. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein bL17m
Names
39S ribosomal protein L17, mitochondrial
Na++/Ca++ exchanger-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313842.1 → NP_001300771.1  large ribosomal subunit protein bL17m isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    FM050943, FM126647, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q6PDW6, Q9EPG8
    UniProtKB/TrEMBL
    A0A8I6A9S2, A6I7N9
    Conserved Domains (1) summary
    pfam01196
    Location:28 → 126
    Ribosomal_L17; Ribosomal protein L17

  2. NM_001313843.1 → NP_001300772.1  large ribosomal subunit protein bL17m isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    FM050943, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I7N7
    Conserved Domains (1) summary
    pfam01196
    Location:28 → 99
    Ribosomal_L17; Ribosomal protein L17

  3. NM_133539.2 → NP_598223.2  large ribosomal subunit protein bL17m isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    FM050864, FM099507, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q6PDW6, Q9EPG8
    UniProtKB/TrEMBL
    A0A8I6A9S2, A6I7N9
    Related
    ENSRNOP00000090550.1, ENSRNOT00000102735.2
    Conserved Domains (1) summary
    pfam01196
    Location:28 → 126
    Ribosomal_L17; Ribosomal protein L17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    169574010..169575699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDW6.1 GenPept UniProtKB/Swiss-Prot:Q6PDW6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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